Pancreatic Cell News 10.48 December 10, 2019 | |
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TOP STORYSerotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation In β-cell-specific Tph1 knockout mice, perinatal β-cell proliferation was reduced along with the loss of serotonin production in β-cells. Disruption of serotonin receptor 2B in β-cells also resulted in decreased perinatal β-cell proliferation and glucose intolerance in adulthood. [Diabetes] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISResearchers exposed pancreatic beta-cells to non-lethal concentrations of p,p′-DDT (1,1′-(2,2,2-Trichloroethane-1,1-diyl)bis(4-chlorobenzene)) and p,p′-DDE (1,1′-(2,2-dichloroethene-1,1-diyl)bis(4-chlorobenzene)) for one month, and assessed changes in protein expression and intracellular insulin level. [Sci Rep] Full Article PANCREATIC CANCERCompared to human pancreatic ductal epithelial cells hTERT-HPNE, more significant growth-inhibitory effects were seen in pancreatic ductal adenocarcinoma cells BxPC-3 and MIA PaCa-2. Scientists showed that apoptosis was induced and that the cell cycle was arrested when cells were treated with hydroxyflavanone. [Cancer Lett] Full Article Researchers identified 585 unique S-nitrosylation sites among 434 proteins in pancreatic ductal adenocarcinoma patients and PANC-1 cell line by a site-specific proteomics. Larger number of S-nitrosylated proteins were identified in pancreatic ductal adenocarcinoma tissues and PANC-1 cells than adjacent non-cancerous tissues. [Cell Death Dis] Full Article Protein Kinase D1 Regulates Metabolic Switch in Pancreatic Cancer via Modulation of mTORC1 Protein kinase D1 expression in pancreatic cancer was investigated by using immunohistochemistry. Functional and metabolic assays were utilized to analyze the effect of protein kinase D1 expression/knockdown on associated cellular/molecular changes. [Br J Cancer] Abstract Pancreatic ductal adenocarcinoma cell growth, migration and death were assessed by using sulforhodamine-B/tetrazolium-based assays, gap closure assay and poly-ADP ribose polymerase cleavage, respectively. The PKM2 inhibitor reduced pancreatic ductal adenocarcinoma cell proliferation, cell migration and induced cell death. [Br J Cancer] Full Article In HPAF-II cells knockout of CEACAM6 altered extracellular matrix-cell adhesion, catabolism, immune environment, transmembrane transport and autophagy. CEACAM6 loss increased mitochondrial basal and maximal respiratory capacity. [Sci Rep] Full Article The authors investigated the anti-tumor effects of MBRI-001 in combination with gemcitabine in BxPC-3 and MIA PaCa-2 human pancreatic cancer cell lines. In vitro and in vivo results indicated that MBRI-001 showed synergistic activity with gemcitabine. [Invest New Drugs] Abstract Scientists found that the expression of the lncRNA EPIC1 was high in pancreatic cancer and closely related to tumor size, TNM staging and lymph node metastasis status. [Biochem Biophys Res Commun] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSMicrobiota in Pancreatic Health and Disease: The Next Frontier in Microbiome Research The authors examine literature implicating microorganisms in diseases of the pancreas, specifically pancreatitis, type 1 diabetes mellitus and pancreatic ductal adenocarcinoma. [Nat Rev Gastroenterol Hepatol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSArecor Limited announces positive headline results for the Phase I clinical trial of its ultra-rapid acting insulin product candidate, AT247. In the study, AT247 provided a favorable pharmacokinetic/pharmacodynamic profile compared with NovoRapid® and Fiasp®. [Arecor Limited (GlobeNewswire, Inc.)] Press Release The University of Arizona Cancer Center has been awarded $6.85 million to continue its efforts in cancer research, training and outreach programs serving Arizona Native American communities. [The University of Arizona] Press Release | |
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POLICY NEWSProPublica Creates Database of Researchers’ Conflicts of Interest Over the past year, ProPublica has sought to highlight the potential conflicts of interest- professional relationships that might influence research, teaching, and other activities—of faculty members at public universities and research institutions and has created a database of professors’ corporate and nonprofit funding. [The Scientist] Editorial Tufts to Remove Sackler Name from Medical Campus Tufts University will not return donations from the family that made its riches on opioids, but the university will start a $3 million endowment for addiction prevention and treatment. [The Scientist] Editorial Merck and Sanofi Buy Smaller Cancer Drug Firms at Big Premiums, Fueling Investor Excitement The drug giants Merck and Sanofi each said they would acquire a smaller drug maker for more than $2 billion – in each case, more than double the smaller company’s market capitalization – cheering investors about large companies’ appetite to execute buyouts in the biotechnology sector. [STAT News] Editorial House Republicans Fuel Capitol Hill Chaos with Competing Drug Pricing Bill Republicans are set to accelerate Capitol Hill’s drug pricing chaos with a new proposal to lower the cost of prescription medicines, according to a summary document obtained by STAT. [STAT News] Editorial
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EVENTSNEW Advances in Liquid Biopsies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen) Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München) Postdoctoral Position – Pancreatic Cancer Bioinformatics (University of Copenhagen) Postdoctoral Researcher – Islet Biology, Stem Cells and Regenerative Medicine (University of Geneva) Postdoctoral Fellow – Type I Diabetes Research (German Research Center for Environmental Health) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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