Pancreatic Cell News Volume 11.01 | Jan 14 2020

TOP STORY

Transcription Phenotypes of Pancreatic Cancer Are Driven by Genomic Events during Tumor Evolution

Transcriptome analysis demonstrated that molecular subtypes were a product of a gene expression continuum driven by a mixture of intratumoral subpopulations, which was confirmed by single-cell analysis. [Nat Genet] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Variants That Affect Function of Calcium Channel TRPV6 Are Associated with Early-Onset Chronic Pancreatitis: TRPV6 and Pancreatitis

Scientists expressed TRPV6 variants in HEK293 cells and measured their activity using Ca²⁺ imaging assays. Chronic pancreatitis was induced by repeated injections of cerulein in TRPV6^mut/mut mice. [Gastroenterology] Abstract

Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells

Researchers capitalized on a YAP overexpression system to induce replication of stem-cell-derived β cells and, by single-cell RNA sequencing, identified an upregulation of the leukemia inhibitory factor pathway. [Cell Metab] Abstract

Mitochondrial Ca²⁺ Uptake Relieves Palmitate-Induced Cytosolic Ca²⁺ Overload in MIN6 Cells

Investigators observed palmitate upregulated mitochondrial Ca²⁺ uniporter protein expression in a mouse clonal β-cell, MIN6, under normal glucose, but not high glucose medium. [Mol Cells] Abstract

nAChR Signaling Regulates IRE1α Activation to Protect β Cells against Terminal Unfolded Protein Response under Irremediable ER Stress

The effects of nicotine on inositol-requiring enzyme 1α activation and key terminal unfolded protein response markers, thioredoxin-interacting protein and Insulin/proinsulin, were analyzed by real time PCR and Western blotting in rat INS-1 and human EndoC-βH1 β cell lines. [J Diabetes Investig] Abstract | Full Article

PANCREATIC CANCER

Regulatory T Cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

The authors showed that regulatory T cells were a key source of TGFβ ligands and, their depletion reprogramed the fibroblast population, with loss of tumor-restraining, smooth muscle actin-expressing fibroblasts. [Cancer Discov] Abstract

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Scientists described simple cholesterol-modified polymeric CXCR4 antagonist nanoparticles to block cancer-stroma interactions for codelivery of anti-miR-210 to inactivate stroma-producing pancreatic stellate cells and siKRAS^G12D to kill pancreatic cancer cells. [ACS Nano] Abstract

Hsa_circ_001653 Implicates in the Development of Pancreatic Ductal Adenocarcinoma by Regulating MicroRNA-377-Mediated HOXC6 Axis

Researchers investigated the role of hsa_circ_001653 in the development of pancreatic ductal adenocarcinoma. Phenotypic changes of pancreatic ductal adenocarcinoma cells were evaluated by assays for cell viability, cell cycle, invasion, and apoptosis. [Mol Ther Nucleic Acids] Abstract | Full Article

Glycofullerenes as Non-Receptor Tyrosine Kinase Inhibitors – Towards Better Nanotherapeutics for Pancreatic Cancer Treatment

Molecular biology studies revealed no cytotoxicity and no influence of engineered carbon nanomaterials on the cell cycle of PANC-1 and AsPC-1 cancer cell lines. [Sci Rep] Full Article

Effects of Evodiamine on PI3K/Akt and MAPK/ERK Signaling Pathways in Pancreatic Cancer Cells

Scientists investigated the effects of evodiamine on the proliferation, apoptosis and autophagy of human pancreatic cancer cell lines in vitro and in vivo. [Int J Oncol] Abstract

Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News.

Impact of Circadian Disruption on Glucose Metabolism: Implications for Type 2 Diabetes

The authors review the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. [Diabetologia] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Rafael Pharmaceuticals Crosses Halfway Enrollment Point in Pivotal Phase III Trial of CPI-613^®️ for Patients with Metastatic Pancreatic Cancer

Rafael Pharmaceuticals, Inc. announced that it has reached an enrollment milestone of more than 250 patients in its pivotal Phase III clinical trial for metastatic pancreatic cancer, which is evaluating the efficacy and safety of Rafael’s lead compound CPI-613^®️ in combination with modified FOLFIRINOX as first-line therapy. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release

RenovoRx and Parexel Biotech Reach Key Milestone in Clinical Trial for Locally-Advanced Pancreatic Cancer

RenovoRx, Inc. announced the TIGeR-PaC Phase III clinical trial of Trans-Arterial Micro-Perfusion has reached its first patient enrolled in Europe. Overall trial enrollment is on schedule and is exceeding 20 percent worldwide. [RenovoRx, Inc.] Press Release

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial

Protect India’s Universities

For several weeks the world has watched as India’s citizens – including academics and students – have taken to the streets. Tens of thousands have been gathering to read out the preamble to the Indian constitution, as a mark of protest against a discriminatory new citizenship law. [Nature News] Editorial

NEW American Association for Cancer Research (AACR) Meeting: The Microbiome and Viruses
February 21-24, 2020
Orlando, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center)

Postdoctoral Fellow – Tumor Immunology in Pancreatic Cancer (University Hospital Carl Gustav Carus Dresden)

Postdoctoral Research Fellow – Novel Drivers of Pancreatic Cancer (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University)

Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University)

Postdoctoral Fellow Positions – Genetics and Diabetes (University of Pennsylvania)

Postdoctoral Researchers – Cell Biology (Karolinska Institutet)

Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen)

Postdoctoral Position – Cellular Signaling Mechanisms in Pancreatic Ductal Adenocarcinoma (Universitätsklinikum Freiburg)

Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Pancreatic Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.