Pancreatic Cell News Volume 11.10 | Mar 17 2020

TOP STORY

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

Researchers utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shaped tumor immunity and progression. Neoantigen expression in pancreatic ductal adenocarcinoma resulted in exacerbation of a fibro-inflammatory microenvironment that drove disease progression and metastasis. [Cancer Cell] Full Article | Graphical Abstract

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DIABETES & PANCREATITIS

Protection from β-Cell Apoptosis by Inhibition of TGF-β/Smad3 Signaling

Human islets undergoing β-cell apoptosis released increased levels of TGF-β1 ligand and phosphorylation levels of TGF-β’s chief transcription factor, Smad3, were increased in human type 2 diabetes islets. [Cell Death Dis] Full Article

Copper Promotes Sheep Pancreatic Duct Organoid Growth by ATOX1-Dependent MEK-ERK Pathway Activation

Scientists found that an appropriate amount of copper benefited the formation and growth of sheep pancreatic duct organoids (sPDOs), whereas excess or deficient copper damaged sPDOs. [Am J Physiol Cell Physiol] Abstract

PANCREATIC CANCER

piRNA-Independent Function of PIWIL1 as a Co-Activator for Anaphase Promoting Complex/Cyclosome to Drive Pancreatic Cancer Metastasis

Investigators showed that in the absence of piRNAs, human PIWIL1 in pancreatic ductal adenocarcinoma (PDAC) functions as an oncoprotein by activating the anaphase promoting complex/cyclosome E3 complex, which then targeted a critical cell adhesion-related protein, Pinin, to enhance PDAC metastasis. [Nat Cell Biol] Abstract

PRDM3 Attenuates Pancreatitis and Pancreatic Tumorigenesis by Regulating Inflammatory Response

Investigators examined PRDM3 function in pancreatic acinar cells during tumor formation and pancreatitis by inactivating Prdm3 using a conditional allele in the context of oncogenic Kras expression and supraphysiological cerulein injections. [Cell Death Dis] Full Article

TFEB-Mediated Lysosomal Biogenesis and Lysosomal Drug Sequestration Confer Resistance to MEK Inhibition in Pancreatic Cancer

To identify potential resistance mechanisms underlying MEK inhibitor resistance in pancreatic ductal adenocarcinoma (PDAC), scientists investigated lysosomal drug accumulation in PDAC models both in vitro and in vivo. [Cell Death Discov] Full Article

Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells

Researchers showed that pancreatic adenocarcinoma (PDAC) cells expressing the lactate-importer MCT1 were protected by lactate against gemcitabine-induced apoptosis in a MCT1-dependent fashion, contrary to MCT1-negative PDAC cells. [Cancers] Full Article

Antibiotic Tigecycline Inhibits Cell Proliferation, Migration and Invasion via Down-Regulating CCNE2 in Pancreatic Ductal Adenocarcinoma

The authors assessed the effect of tigecycline in pancreatic ductal adenocarcinoma cells. AsPC-1 and HPAC cells were treated with indicated concentrations of tigecycline for indicated time, and MTT, BrdU and soft agar assay were used to test cell proliferation. [J Cell Mol Med] Full Article

Delivery of Small Molecule EF2 Kinase Inhibitor for Breast and Pancreatic Cancer Cells Using Hyaluronic Acid Based Nanogels

In vitro cellular uptake studies of Rhodamine 6G labaled HA:Suc nanoparticles were evaluated by using flow cytometry analysis and fluorescent microscopy in breast and pancreatic cancer cells. [Pharm Res] Abstract | Graphical Abstract

Skullcapflavone I Has a Potent Anti-Pancreatic Cancer Activity by Targeting miR-23a

Cell viability, Bromodeoxyuridine (BrdU)-positive cell rate, apoptosis, migration, invasion, and related protein expression were assessed by utilizing Cell Counting Kit-8, BrdU staining, apoptosis assessment, transwell assay, and western blot. SFI significantly reduced the proliferation, migration, and invasion, as well as induced apoptosis of Panc-1 cells. [Biofactors] Abstract

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Burden of Pancreatic Cancer – From Epidemiology to Practice

The authors review the epidemiologic features of pancreatic cancer, covering surveillance and early detection in high-risk persons. [Clin Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

PharmaCyte Biotech Addresses Submission of IND and Recent FDA-Required Testing

PharmaCyte Biotech, Inc. announced the latest in its series of Q&A articles that are conducted with some of the key management members of PharmaCyte’s research and development team related to its upcoming clinical trial in locally advanced, inoperable pancreatic cancer. [PharmaCyte Biotech, Inc.] Press Release

Cancer Council NSW Awards over $9 Million of Funding to Innovative Cancer Research

Cancer Council NSW has awarded over $9 million of new funding to 14 ground-breaking cancer research projects. The projects span a range of cancers, including four low survival cancers: ovarian, stomach, liver and pancreatic. [Cancer Council NSW] Press Release

Journals, Peer Reviewers Cope with Surge in COVID-19 Publications

Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist] Editorial

Near-Lockdown in the Bay Area ‘Ratchets Up’ Challenges for Local Biotechs and Labs

At the stroke of midnight on Tuesday morning, seven counties in the San Francisco Bay Area went into near-lockdown – ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News] Editorial

NEW International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs
October 12-14, 2020
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine)

Postdoctoral Fellowships – Pancreatic Disease (University of Copenhagen)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Investigator Group Leader – Metabolic Research in Diabetes (German Research Center for Environmental Health)

Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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