Prostate Cell News Volume 10.27 | Jul 26 2019

TOP STORY

Gene Test Picks Out Prostate Cancer Patients Who Could Benefit from ‘Search-and-Destroy’ Medicine

Testing for genetic weaknesses in repairing DNA could pick out men who may benefit from a new type of targeted nuclear medicine. Scientists at The Institute of Cancer Research, London, found that testing men for faults in DNA repair genes in their tumors could identify those most likely to respond to a new type of treatment. [Institute of Cancer Research] Press Release | Full Article

(Ranked by impact factor of the journal)

Circulating IGF-1 Promotes Prostate Adenocarcinoma via FOXO3A/BIM Signaling in a Double-Transgenic Mouse Model

Researchers crossed a transgenic prostate adenocarcinoma mouse model, Hi-Myc mice, with a liver-specific insulin-like growth factor-1 (IGF-1) transgenic mouse model to increase their circulating IGF-1 levels to investigate the impact of the elevated circulating IGF-1 on prostate cancer development in vivo. [Oncogene] Abstract

GnRH Antagonists Have Direct Inhibitory Effects on Castration-Resistant Prostate Cancer via Intracrine Androgen and AR-V7 Expression

In C4-2B MDVR cells, degarelix alone or combined with abiraterone or enzalutamide reduced AR-V7 protein expression compared to the control group. SCID mice bearing VCaP xenograft tumors were divided into four groups and treated with surgical castration, degarelix, leuprolide or buffer alone for four weeks. [Mol Cancer Ther] Abstract

Circular RNAs Are Differentially Expressed in Prostate Cancer and Are Potentially Associated with Resistance to Enzalutamide

Androgen receptor (AR)-V7 expression was assessed in an isogenic model of enzalutamide resistance. The model consisted of age matched control cells and two sub-line clones displaying varied resistance to enzalutamide. [Sci Rep] Full Article

Low Expression of miR-424-3p Is Highly Correlated with Clinical Failure in Prostate Cancer

The clinical significance of miR-424-3p expression in prostate cancer tissue was evaluated. Naïve radical prostatectomy specimens from 535 patients was used for tissue microarray construction. [Sci Rep] Full Article

Identification of the Perturbed Metabolic Pathways Associating with Prostate Cancer Cells and Anticancer Affects of Obacunone

Using high-throughput liquid chromatography-high definition mass spectrometry combined with pattern recognition methods was performed to analyze the cell metabolic profiles and pathway of obacunone on prostate cancer. [J Proteomics] Abstract

T-Type Calcium Channels Drive the Proliferation of Androgen-Receptor Negative Prostate Cancer Cells

Investigators evaluated T-type calcium channel expression in a panel of prostate cancer cell lines and measured the effect of their inhibition on cell proliferation and survival using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and caspase assays. [Prostate] Abstract

Glucocorticoid Receptor Upregulation Increases Radioresistance and Triggers Androgen Independence of Prostate Cancer

Higher glucocorticoid receptor (GR) levels, but lower androgen receptor levels were detected in radioresistant cells than in parental cells. Radiation-induced GR upregulation was associated with increased intracellular cyclic adenosine monophosphate. [Prostate] Abstract

Effect of Polyunsaturated Fatty Acids on Proliferation and Survival of Prostate Cancer Cells

Scientists showed that hormone-dependent cells were comparatively insensitive to various polyunsaturated fatty acids (PUFAs), at the same time as the growth and viability of hormone-independent cells lines were strongly inhibited by most of the tested PUFAs. [PLoS One] Full Article

Paxillin Regulated Genomic Networks in Prostate Cancer

Paxillin enhanced several pro-proliferative pathways, including the CyclinD/Rb/E2F and DNA replication/repair pathways. Additionally, paxillin suppressed pro-apoptotic genes, including CASP1 and TNFSF10. [Steroids] Abstract

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Molecular Underpinnings Governing Genetic Complexity of ETS-Fusion-Negative Prostate Cancer

Inter- and intra-patient molecular heterogeneity of primary and metastatic prostate cancer confers variable clinical outcome and poses a formidable challenge in disease management. The authors focus on the emerging molecular underpinnings driving key oncogenic aberrations and advancements in therapeutic strategies of this disease. [Trends Mol Med] Abstract

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Anixa Biosciences Announces US Department of Veterans Affairs (VA) Maryland Health Care System Joins Cchek™ Prostate Cancer Study

Anixa Biosciences, Inc. announced that it is partnering with the VA Maryland Health Care System’s Baltimore VA Medical Center and the Baltimore Research and Education Foundation, a non-profit affiliate, in its ongoing prostate cancer Cchek™ study. [Anixa Biosciences, Inc.] Press Release

Salarius Pharmaceuticals Enrolls First Patient in a Phase I Clinical Study of Its Novel Inhibitor Targeting Epigenetics in Patients with Advanced Solid Tumors

Salarius Pharmaceuticals, Inc. announced it has enrolled the first patient in a Phase I clinical study of the company’s lead compound, Seclidemstat, in patients with advanced solid tumors resistant to standard-of-care therapies. [Salarius Pharmaceuticals, Inc.] Press Release

Former UK Science Minister Returns as Brexit Government Assembles

The prime minister shake-up sees a return to the Conservative government for Jo Johnson, the prime minister’s brother and a former minister for universities and science. Johnson, who was generally popular with scientists, is back as a minister straddling the Department for Business, Energy and Industrial Strategy — which oversees research — and the Department for Education. [Nature News] Editorial

Indonesia’s Strict New Biopiracy Rules Could Stifle International Research

Indonesia’s rich biodiversity and complex geology have lured scientists from abroad for centuries. But a law adopted by Indonesia’s parliament may convince some to go elsewhere. The legislation includes strict requirements on foreign scientists doing research in Indonesia, including the need to recruit local collaborators and a near-ban on exporting specimens, along with stiff sanctions, including jail time, for violators. [ScienceInsider] Editorial

NEW Keystone Symposia: Single Cell Biology: Pushing New Frontiers in the Life Sciences
May 4-8, 2020
Florence, Italy

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NEW Scientific Communications Coordinator (STEMCELL Technologies Inc.)

NEW Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK)

Research Officer – Tumor Progression (Garvan Institute of Medical Research)

Postdoctoral Researcher – Genitourinary Cancers (CCTI Columbia University)

Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University)

Research Scientist – Prostate Cancer Progression & Resistance (MD Anderson Cancer Center)

Endowed Chair Faculty – Prostate Cancer (Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

Postdoctoral Position – Prostate Biology (University of Washington)

Postdoctoral Scientist – Prostate Organoids (Rutgers Cancer Institute of New Jersey)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Postdoctoral Fellow – Jak-Stat Signaling in Prostate and Pancreatic Cancer (Medical College of Wisconsin)

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