Prostate Cell News Volume 10.30 | Aug 16 2019

TOP STORY

Circulating IGF-1 Promotes Prostate Adenocarcinoma via FOXO3A/BIM Signaling in a Double-Transgenic Mouse Model

Researchers crossed a transgenic prostate adenocarcinoma mouse model, Hi-Myc mice, with a liver-specific insulin-like growth factor-1 (IGF-1) transgenic mouse model to increase their circulating IGF-1 levels and investigate the impact of the elevated circulating IGF-1 on prostate cancer development in vivo. [Oncogene] Abstract

(Ranked by impact factor of the journal)

Circular RNAs Add Diversity to Androgen Receptor Isoform Repertoire in Castration-Resistant Prostate Cancer

Through the analysis of an exome-capture RNA-seq dataset from 47 metastatic castration-resistant prostate cancer samples and ribodepletion and RNase R RNA-sequencing of patient-derived xenografts and cell models, scientists identified 13 circular RNAs generated from the key prostate cancer driver gene-androgen receptor. [Oncogene] Abstract

Acidity Promotes Tumor Progression by Altering Macrophage Phenotype in Prostate Cancer

Activating macrophages at pH 6.8 in vitro enhanced an IL-4-driven phenotype as measured by gene expression, cytokine profiling, and functional assays. These results were recapitulated in vivo wherein neutralizing intratumoral acidity reduced the pro-tumor phenotype of macrophages, while also decreasing tumor incidence and invasion in the TRAMP model of prostate cancer. [Br J Cancer] Full Article

Membrane-Initiated Estrogen Signaling in Prostate Cancer: A Route to Epithelial-to-Mesenchymal Transition

Scientists explored whether estrogen binding sites exist on the plasma membrane (PM) and if such sites are functionally relevant in prostate cancer (PCa). Estradiol binding to the PM was detected in androgen-dependent, androgen-independent PCa cell lines, nontumorigenic prostate epithelial cell line, and rat prostate cells. [Mol Carcinog] Abstract

Co-Carcinogenic Effects of Vitamin E in Prostate

Investigators found that vitamin E in the human prostate epithelial RWPE-1 cell line had the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 enzymes, including activators of polycyclic aromatic hydrocarbons, giving rise to supraphysiological levels of reactive oxygen species. [Sci Rep] Full Article

The Senescence-Associated Secretory Phenotype (SASP) from Mesenchymal Stromal Cells Impairs Growth of Immortalized Prostate Cells but Has No Effect on Metastatic Prostatic Cancer Cells

Researchers evaluated the SASP effect on the in vitro biological properties of PNT2 and PC3 cells, which are immortalized prostate cells and metastatic prostatic cancer cells, respectively. They found that SASPs, coming either from mesenchymal stromal cells treated with H₂0₂ or with low X-ray doses, induced senescence of immortalized cells but not of cancer cells. [Aging (Albany NY)] Full Article

TUBB3 Reverses Resistance to Docetaxel and Cabazitaxel in Prostate Cancer

TUBB3 expression was upregulated in docetaxel (DTX)-resistant and cabazitaxel (CBZ)-resistant cells. TUBB3 knockdown re-sensitized DTX-resistant cells to DTX and CBZ-resistant cells to CBZ. Additionally, TUBB3 knockdown re-sensitized DTX-resistant cell lines to CBZ, indicating that TUBB3 mediates cross-resistance between DTX and CBZ. [Int J Mol Sci] Full Article

Secretome Profiling of PC3/nKR Cells, a Novel Highly Migrating Prostate Cancer Subline Derived from PC3 Cells

Investigators characterized the secretome of PC3/nKR cells, which are a new subline of PC3 cells that were originally isolated from nude mice that were implanted with PC3 cells without anti-natural killer (NK) cell treatment. Wound healing and Transwell assays revealed that PC3/nKR cells had increased migratory and invasive activities in addition to a higher resistance to NK cell-induced cytotoxicity as compared to PC3 cells. [PLoS One] Full Article

MicroRNA-488 Inhibits Proliferation and Glycolysis in Human Prostate Cancer Cells by Regulating PFKFB3

The authors identified 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform3 (PFKFB3) as a direct target of miR-488. Inhibition of PFKFB3 suppressed prostate cancer cell glycolysis and proliferation. [FEBS Open Bio] Abstract | Full Article

Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News.

Future Aspects of CDK5 in Prostate Cancer: From Pathogenesis to Therapeutic Implications

Scientists summarize the significant studies on CDK5-mediated regulation of prostate cancer cells. They propose that the CDK5-p35 complex might be an outstanding candidate as a diagnostic marker and potential target for prostate cancer treatment in the near future. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Profound Medical Receives US FDA 510(k) Clearance for TULSA-PRO^®

Profound Medical has received 510(k) clearance from the FDA to market TULSA-PRO^® for ablation of prostate tissue. [Profound Medical] Press Release

Cytovation and SMS-Oncology Sign Agreement on Conduct of Phase I/II Trial with CyPep-1 in Solid Tumors

Cytovation AS and Specialized Medical Services-Oncology BV (SMS-Oncology) announced that SMS-Oncology has been selected as the CRO to conduct the Phase I/II clinical trial with CyPep-1 in patients with advanced solid cancers. [Cytovation AS] Press Release

Academia to FBI on Monitoring Chinese Scientists: “Tread Carefully”

Nearly two dozen higher education groups warn the government to be cautious when advising US research universities to keep an eye on students and faculty with ties to certain Chinese institutions. [The Scientist] Editorial

For a Decade, Francis Collins Has Shielded NIH—While Making Waves of His Own

Collins has helped shield the National Institutes of Health (NIH) from threatened budget cuts as well as the upheaval that has shaken many other federal agencies under the Trump administration. [Nature News] Editorial

NEW Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges
January 19-23, 2020
Keystone, Colorado, United States

Visit our events page to see a complete list of events in the community.

NEW Senior Research Assistant – Genitourinary Oncology (MD Anderson Cancer Center)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Professor/Associate Professor – Prostate Cancer (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK)

Research Officer – Tumor Progression (Garvan Institute of Medical Research)

Postdoctoral Researcher – Genitourinary Cancers (Columbia University)

Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University)

Endowed Chair Faculty – Prostate Cancer (Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

Postdoctoral Position – Prostate Biology (University of Washington)

Postdoctoral Scientist – Prostate Organoids (Rutgers Cancer Institute of New Jersey)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.