Prostate Cell News Volume 10.43 | Nov 15 2019

TOP STORY

A Non-Radioactive Cell Assay for the Evaluation of Modular Prostate-Specific Membrane Antigen Targeting Ligands via Inductive Coupled Plasma Mass Spectrometry

Scientists described an inductive coupled plasma mass spectrometry based method for the evaluation of prostate-specific membrane antigen (PSMA)-targeting ligands conjugated to DOTA-chelates of europium. The method was based on LNCaP and PC-3 cells and was validated with the well-established targeting ligand PSMA-617. [J Med Chem] Abstract

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Acetyl-L-Carnitine Downregulates Invasion (CXCR4/CXCL12, MMP-9) and Angiogenesis (VEGF, CXCL8) Pathways in Prostate Cancer Cells: Rationale for Prevention and Interception Strategies

The chemopreventive/angiopreventive activities acetyl-L-carnitine were investigated in vitro on four different prostate cancer cell lines and a benign prostatic hyperplasia cell line. [J Exp Clin Cancer Res] Full Article

A PSCA/PGRN – NF-κB – Integrin-α4 Axis Promotes Prostate Cancer Cell Adhesion to Bone Marrow Endothelium and Enhances Metastatic Potential

Investigators characterized the roles of prostate stem cell antigen in the adhesion of prostate cancer cells to bone marrow endothelial cells. Cell adhesion was assessed using the adhesion assay and transendothelial migration. [Mol Cancer Res] Abstract

Pentamidine Inhibits Prostate Cancer Progression via Selectively Inducing Mitochondrial DNA Depletion and Dysfunction

Prostate cancer cell lines and epithelial RWPE-1 cells were used. Cell viability, wound-healing, transwell and apoptosis assays were examined to evaluate the influences of pentamidine in vitro. [Cell Prolif] Full Article

Long Noncoding RNA DNM3OS Promotes Prostate Stromal Cells Transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 Axes

Collagen Type III was significantly upregulated by transforming growth factor-β1 (TGFβ1) in prostate stromal cells and might be involved in DNM3OS function in myofibroblasts upon TGFβ1 stimulation. [Aging (Albany)] Full Article

Resveratrol Induces Depletion of TRAF6 and Suppresses Prostate Cancer Cell Proliferation and Migration

Researchers investigated the effect and mechanism of resveratrol function in prostate cancer cell proliferation and migration and reported that TNF-receptor associated factor 6 (TRAF6) was a key mediator of resveratrol function to inhibit prostate cancer cell growth and proliferation. [Int J Biochem Cell Biol] Abstract | Graphical Abstract

Isoquinolinamine FX-9 Exhibits Anti-Mitotic Activity in Human and Canine Prostate Carcinoma Cell Lines

FX-9′s mediated effects were characterized on two human and two canine prostate cancer cell lines, as well as benign solid tissue cells. FX-9 significantly inhibited cell viability and induced apoptosis with concentrations in the low micromolar range. [Int J Mol Sci] Full Article

Long Noncoding RNA RBMS3-AS3 Acts as a MicroRNA-4534 Sponge to Inhibit the Progression of Prostate Cancer by Upregulating VASH1

Scientists investigated the potential role of RBMS3-AS3/miR-4534/VASH1 axis in the development of prostate cancer. The biological functions of RBMS3-AS3, miR-4534, and VASH1 on cell proliferation, migration, invasion, and angiogenesis of prostate cancer were evaluated via gain- and loss-of-function experiments. [Gene Ther] Abstract

Exploring the Impact of a Naturally Occurring Sapogenin Diosgenin on Underlying Mechanisms of Ca²⁺ Movement and Cytotoxicity in Human Prostate Cancer Cells

The authors investigated the effect of diosgenin on intracellular Ca²⁺ concentration and cytotoxicity in PC3 human prostate cancer cells. Diosgenin (250-1000 μM) caused intracellular Ca²⁺ concentration rises which was reduced by Ca²⁺ removal. [Environ Toxicol] Abstract

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Cytoreductive Treatment Strategies for De Novo Metastatic Prostate Cancer

Scientists summarize the pathobiological rationale for local cytoreduction and the potentially systemic immunological responses to radiotherapy and ablative therapies in patients with metastatic prostate cancer. [Nat Rev Clin Oncol] Abstract

Radium-223 Mechanism of Action: Implications for Use in Treatment Combinations

Combination therapies of radium-223 with microtubule-stabilizing cytotoxic drugs and agents targeting the androgen receptor axis, immune checkpoint receptors or DNA damage response proteins are being explored in patients with castration-resistant prostate cancer and metastatic bone disease. [Nat Rev Urol] Abstract

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Gossamer Bio Announces Clinical Trial Collaboration Agreement With Merck to Evaluate GB1275 in Combination With KEYTRUDA^® (Pembrolizumab) in Selected Advanced Solid Tumors

Gossamer Bio, Inc. announced that it has entered into a clinical collaboration agreement with Merck to evaluate the combination of Gossamer’s investigational product candidate GB1275, and Merck’s anti-PD-1 therapy, KEYTRUDA^® in patients with selected advanced solid tumors. [Gossamer Bio, Inc.] Press Release

OSE Immunotherapeutics Announces Licensing Deal for Neoepitope Combination Tedopi^® in Korea with Chong Kun Dang Pharmaceutical Corporation

OSE Immunotherapeutics announced a new licensing deal with Chong Kun Dang Pharmaceutical Corporation for Tedopi^® for potential registration and commercialization in Korea. [OSE Immunotherapeutics] Press Release

Italy to Launch National Agency for Research

Just two months after Italy underwent a crisis of government and established an alliance between two leading political parties, the left-of-center Democratic Party and the anti-establishment Five Star Movement, the country has announced plans to start a National Agency for Research to help oversee the distribution of federal funds. [The Scientist] Editorial

EPA’s ‘Secret Science’ Plan Is Back, and Critics Say It’s Worse

Critics are blasting a revised Trump administration plan to give the EPA broad power to ignore research results when setting public health rules if officials decide the underlying data are not adequately accessible to the public. [ScienceInsider] Editorial

The Mental Health of PhD Researchers Demands Urgent Attention

Two years ago, a student responding to Nature’s biennial PhD survey called on universities to provide a quiet room for “crying time” when the pressures caused by graduate study become overwhelming. At that time, 29% of 5,700 respondents listed their mental health as an area of concern – and just under half of those had sought help for anxiety or depression caused by their PhD study. Things seem to be getting worse. [Nature News] Editorial

NEW The Evolving Landscape of Cancer Modeling
March 2-5, 2020
San Diego, California, United States

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NEW Assistant/Associate Faculty Position – Prostate Cancer Research (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Max Delbrück Center for Molecular Medicine)

Senior Research Associate – Chemical Biology and Molecular Cell Biology of Cancer (Lancaster University)

Postdoctoral Position – Identification of RNA Risk Elements in Cancer Biology (University of Maryland Eastern Shore)

Clinical Research Scientist – Investigational Cancer Therapeutics (MD Anderson Cancer Center)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

Postdoctoral Studentship – Genomics of Hereditary Prostate Cancer (University of Manchester)

Postdoctoral Researcher – Prostate Tumor Microenvironment (NorthShore University Health System)

Postdoctoral Researcher – Prostate Cancer (University of California, San Francisco)

Postdoctoral Scholar – Hormone Therapy Resistance in Prostate Cancer (Duke University Medical Center)

Assistant Professor – Biology of Genitourinary Cancers (University of Chicago)

Postdoctoral Fellowship – Prostate Cancer (Weill Cornell Medicine)

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