Prostate Cell News Volume 11.02 | Jan 24 2020

TOP STORY

Androgen Deprivation Upregulates SPINK1 Expression and Potentiates Cellular Plasticity in Prostate Cancer

Researchers showed androgen receptor and its corepressor, REST, function as transcriptional-repressors of SPINK1, and androgen receptor-antagonists alleviated this repression leading to SPINK1 upregulation. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Noncoding Mutations Target cis-Regulatory Elements of the FOXA1 Plexus in Prostate Cancer

Scientists found that deletion and repression of these cis-regulatory elements significantly decreased FOXA1 expression and prostate cancer cell growth. [Nat Commun] Full Article

GRK2 Enforces Androgen Receptor Dependence in the Prostate and Prostate Tumors

Prostate-specific expression of a dominant-negative G protein-coupled receptor kinase 2 transgene diminished androgen receptor and androgen receptor target gene expression in the prostate, and conferred resistance to castration-induced involution. [Oncogene] Abstract

Unleashing the Full Potential of Hsp90 Inhibitors as Cancer Therapeutics through Simultaneous Inactivation of Hsp90, Grp94, and TRAP1

Pan-Hsp90 inhibition increased cytotoxicity and suppressed mechanisms that protect cancer cells, suggesting that it was a feasible strategy for the development of potent anticancer drugs. [Exp Mol Med] Full Article

Resistance to MET/VEGFR2 Inhibition by Cabozantinib Is Mediated by YAP/TBX5-Dependent Induction of FGFR1 in Castration-Resistant Prostate Cancer

Investigators performed parallel investigations in specimens from cabozantinib-treated patients to confirm in vitro and in vivo data. They demonstrated transcriptional activation of FGF/FGFR1 expression in cabozantinib-resistant models. [Cancers] Full Article

SPOP Is Essential for DNA-Protein Crosslink Repair in Prostate Cancer Cells: SPOP-Dependent Removal of Topoisomerase 2A from the Topoisomerase 2A-DNA Cleavage Complex

The depletion of speckle- type POZ protein (SPOP) or overexpression of a prostate cancer-associated SPOP mutant, F133V, in androgen receptor-positive prostate cancer cells increased the amount of topoisomerase 2A in the nuclei together with the increased amount of γH2AX, an indication of DNA breaks. [Mol Biol Cell] Abstract

Tannic Acid Inhibits Lipid Metabolism and Induce ROS in Prostate Cancer Cells

Scientists assessed the tannic acid lipid-targeting ability and its capability to induce endoplasmic reticulum stress by reactive oxygen species in prostate cancer cells. [Sci Rep] Full Article

Geranylated 4-Phenylcoumarins Extracted from Mesua elegans Induced Caspase-Independent Cell Death in Prostate Cancer Cell Lines through Calpain-2 and Cathepsin B

Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death in prostate cancer cell lines. [Sci Rep] Full Article

Exendin-4 Enhances the Sensitivity of Prostate Cancer to Enzalutamide by Targeting Akt Activation

Exendin-4 in combination with enzalutamide dramatically suppressed tumor growth of prostate cancer cells compared to enzalutamide alone; exendin-4 was capable of antagonizing enzalutamide-induced invasion and migration of both prostate cancer cells. [Prostate] Abstract

IL-1-Conferred Gene Expression Pattern in ERα⁺ BCa and AR⁺ PCa Cells Is Intrinsic to ERα^– BCa and AR^– PCa Cells and Promotes Cell Survival

Scientists performed RNA sequencing for hormone receptor-positive breast cancer and prostate cancer cell lines exposed to IL-1 and for untreated hormone receptor-negative breast cancer and prostate cancer cell lines. [BMC Cancer] Full Article

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Advances of Zinc Signaling Studies in Prostate Cancer

The authors review literature related to the content, biological function, compounds and clinical application of zinc in prostate cancer. They summarize zinc content in prostate tissue and sera of prostate cancer patients with their clinical relevance. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Myriad Submits sPMA for BRACAnalysis^® CDx as a Companion Diagnostic for Lynparza^® in Metastatic Castration-Resistant Prostate Cancer

Myriad Genetics, Inc. announced that it has submitted a supplementary premarket approval application to the US FDA for its BRACAnalysis^® CDx test as a companion diagnostic to AstraZeneca’s and Merck’s PARP inhibitor Lynparza^® for men with metastatic castration-resistant prostate cancer. [Myriad Genetics, Inc.] Press Release

INHIBITOR Therapeutics Receives Prostate Cancer IND Clearance from FDA

INHIBITOR Therapeutics, Inc. announced that the company has received Investigational New Drug (IND) clearance from the FDA to initiate an IND-opening clinical study as a two-part, multi-center, randomized, double-blind, placebo-controlled, Phase IIb clinical trial that will evaluate the efficacy and safety of SUBA-Itraconazole capsules dosed in combination with docetaxel and prednisone in patients with metastatic castrate resistant prostate cancer. [INHIBITOR Therapeutics, Inc.] Press Release

‘We Need a People’s Cryo-EM’ Scientists Hope to Bring Revolutionary Microscope to the Masses

The Laboratory for Molecular Biology, clad in glass the color of sea ice, rises like a futuristic factory above the rapeseed fields of Cambridge, UK. It is the crown jewel of the UK Medical Research Council, a storied government lab that has garnered more than a dozen Nobel Prizes. [ScienceInsider] Editorial

Campus Attacks by Nationalists and Police Alarm India’s Scientific Community

The attack on one of India’s most prestigious universities sent shock waves around the country and is the latest sign that the political forces tearing apart Indian society are also affecting the country’s academic community. Students at JNU, a liberal bastion, had been on strike for months against both a major hike in student fees and the government’s controversial Citizenship Amendment Act, widely decried as discriminatory against Muslims. [ScienceInsider] Editorial

NEW 2^nd Nuclear Receptors Conference
February 24-27, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Organoid Models of Prostate Cancer (University of Freiburg)

NEW Research Fellow – Anti-Cancer Therapy (Mayo Clinic)

Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

Postdoctoral Fellow – Cancer Biology (City of Hope)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico)

Postdoctoral Researcher – Chromatin Structures in Cancer Cell States (Medical University of Gdańsk)

Endowed Chair Faculty – Genitourinary Malignancies Research Center (Cleveland Clinic)

Postdoctoral Fellow – Molecular Mechanisms Promoting Aggressiveness in Prostate Cancer (Thomas Jefferson University)

Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

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