Prostate Cell News Volume 11.06 | Feb 21 2020

TOP STORY

Klf5 Acetylation Regulates Luminal Differentiation of Basal Progenitors in Prostate Development and Regeneration

In human and mouse prostates, Klf5 was expressed in both basal and luminal cells, with basal cells preferentially expressing acetylated Klf5. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

MAOA-Mediated Reprogramming of Stromal Fibroblasts Promotes Prostate Tumorigenesis and Cancer Stemness

Monoamine oxidase A (MAOA) in stromal fibroblasts provided tumor cell growth advantages through paracrine IL-6/STAT3 signaling. Downstream of stromal MAOA, STAT3 promoted cell stemness and transcriptionally activated expression of cancer stem cell marker CD44 in prostate cancer cells. [Oncogene] Abstract

YAP1 Plays a Key Role of the Conversion of Normal Fibroblasts into Cancer-Associated Fibroblasts That Contribute to Prostate Cancer Progression

The effects of conditioned media from different fibroblasts on the proliferation and invasion of epithelial cells TrampC1 were examined. [J Exp Clin Cancer Res] Full Article

Prostate Cancer Risk SNP rs10993994 Is a Trans-eQTL for SNHG11 Mediated through MSMB

Removing rs10993994 in LNCaP cell lines by CRISPR/Cas9 editing showed that the C-allele corresponded with an over 100-fold increase in MSMB expression and 5-fold increase in SNHG11 compared to the T-allele. [Hum Mol Genet] Abstract

Anti-Tumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models

Scientists evaluated the anti-tumor activity of xentuzumab, alone and in combination with enzalutamide, in prostate cancer cell lines using established in vitro assays, and in vivo, using a prostate cancer patient-derived xenograft model. [Mol Cancer Ther] Abstract

The Impact of Cand1 in Prostate Cancer

In vitro experiments in different prostate cancer cell lines revealed that knockdown of cullin-associated neural-precursor-cell-expressed developmentally down-regulated 8 dissociated protein 1 (Cand1) reduced cell viability and proliferation and increased apoptosis, therefore underlining its role in tumor progression. [Cancers] Full Article

Chronic Exposure to Cadmium Induces a Malignant Transformation of Benign Prostate Epithelial Cells

Investigators deciphered the molecular signaling responsible for benign prostatic hyperplasia (BPH)1 transformation via RNA-sequencing and determined that cadmium induced the expression of zinc finger of the cerebellum 2 in BPH1 cells. [Oncogenesis] Full Article

Study of Glycosylation of Prostate-Specific Antigen Secreted by Cancer Tissue-Originated Spheroids Reveals New Candidates for Prostate Cancer Detection

The glycan profile of prostate-specific antigen (PSA) from cancer tissue-originated spheroids was determined by comparing with PSA from normal seminal plasma and cancer cell lines using lectin chromatography and mass spectrometry. [Sci Rep] Full Article

A Comparison of Prostate Cancer Cell Transcriptomes in 2D Monoculture vs 3D Xenografts Identify Consistent Gene Expression Alterations Associated with Tumor Microenvironments

Comparisons of gene expression profiles of tumor cells grown in 2D vs 3D environments identified gene sets featuring similar expression patterns in all three cancer cell lines and unique transcriptional signatures associated with 3D versus 2D growth. [Prostate] Abstract

Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells

Prostate adenocarcinoma-derived PC-3 cells were cultivated on an random positioning machine for time periods of three and five days. Researchers investigated the genes associated with the cytoskeleton, focal adhesions, extracellular matrix, growth, survival, angiogenesis, and metastasis. [Int J Mol Sci] Full Article

Arctigenin Induces Necroptosis through Mitochondrial Dysfunction with CCN1 Upregulation in Prostate Cancer Cells under Lactic Acidosis

Investigators studied the underlying mechanism of action of arctigenin on acidity-tolerant prostate cancer PC-3AcT cells in the lactic acid-containing medium. [Mol Cell Biochem] Abstract

Silymarin Inhibited DU145 Cells by Activating SLIT2 Protein and Suppressing Expression of CXCR4

Researchers explored cytotoxic and morphological effects of silymarin on DU145 cells and to reveal its role in Slit2/Robo and CXCR1 pathway. [Med Oncol] Abstract

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DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer

The common features of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) and the similarities in their noncanonical roles as transcription coregulators of the androgen and its receptor are highlighted. [Trends Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

CytoDyn Receives Institutional Review Board Approval to Initiate Phase II Basket Trial for 22 Solid Tumor Cancers

CytoDyn, Inc. reported that it has received Institutional Review Board approval to begin its Phase II clinical trial for the treatment of approximately 22 different solid tumor cancers. [CytoDyn, Inc.] Press Release

LuPIN Trial Interim Results Indicate Striking Survival Benefit

Noxopharm, Inc. announces positive interim results from its LuPIN Phase I/II clinical trial. The LuPIN study is being conducted by St. Vincent’s Hospital Sydney and is evaluating Noxopharm’s lead drug candidate, Veyonda^®, in combination with 177Lu-PSMA-617, in 56 patients with late-stage metastatic castration-resistant prostate cancer. [Noxopharm, Inc. (BusinessWire, Inc.)] Press Release

The Next Chapter for African Genomics

Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way. [Nature News] Editorial

‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide

Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2020 Annual Meeting
June 24-27, 2020
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Senior Laboratory Research Scientist – Autophagy in Cancer (The Francis Crick Institute)

Postdoctoral Studentship – Stress Signaling and Prostate Cancer (University of Oslo)

Postdoctoral Research Associate – Cancer Development (University of Cambridge)

Postdoctoral Fellow – Prostate Tumorigenesis (University of Cincinnati)

Postdoctoral Fellow – RNA Splicing in Cancer (The University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Organoid Models of Prostate Cancer (University of Freiburg)

Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

Postdoctoral Fellow – Cancer Biology (City of Hope)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico)

Postdoctoral Researcher – Chromatin Structures in Cancer Cell States (Medical University of Gdańsk)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

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