Prostate Cell News Volume 11.12 | Apr 03 2020

TOP STORY

Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo

Scientists describe their findings on the effects of targeted interleukin-27 (IL-27) gene delivery on prostate cancer cells in vitro and in vivo and how the targeting enhanced bioactivity of the IL-27 cytokine. [Mol Ther Methods Clin Dev] Abstract

(Ranked by impact factor of the journal)

Histone Demethylase JMJD1A Promotes Expression of DNA Repair Factors and Radio-Resistance of Prostate Cancer Cells

Ablation of the JMJD1A noncanonical ubiquitination lowered DNA damage response gene expression, impaired double-strand break repair, and sensitized response of prostate cells to irradiation, topoisomerase inhibitors or PARP inhibitors. [Cell Death Dis] Full Article

Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression via Targeting BCL2/ROS/USP26 Axis through Altering ARv7 Protein Degradation

Scientists targeted enzalutamide (Enz)-induced BCL2 with inhibitor ABT263 and tested Enz sensitivity in Enz-resistant prostate cancer cells by MTT assay. [Cancers] Full Article

PAK1 Inhibitor IPA-3 Mitigates Metastatic Prostate Cancer-Induced Bone Remodeling

Scientists report that targeting P21 activated kinase (PAK)1 using IPA-3, an allosteric inhibitor of PAK1 kinase activity, significantly inhibited the murine metastatic prostate cancer cell proliferation and motility in vitro, and metastasis to the lungs in vivo. [Biochem Pharmacol] Abstract | Graphical Abstract

ERβ and NFκB-Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells

Researchers evaluated the role of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and estrogen receptor (ER)β in the induction of oxidative stress in human prostate cancer cells by zearalenone. [Toxins] Full Article

NPRL2 Promotes Docetaxel Chemoresistance in Castration Resistant Prostate Cancer Cells by Regulating Autophagy through the mTOR Pathway

The authors found that nitrogen permease regulator-like 2 (NPRL2) was significantly overexpressed in docetaxel-resistant castration-resistant prostate cancer cells, while autophagy was enhanced and mTOR signaling was inhibited. [Exp Cell Res] Abstract

Differential Targeting of Gr-MDSCs, T Cells and Prostate Cancer Cells by Dactolisib and Dasatinib

Scientists applied reverse phase protein array to profile 297 proteins and protein phosphorylation sites of granulocytic myeloid-derived suppressor cells (Gr-MDSCs), T cells and prostate cancer cells isolated from the castration-resistant prostate cancer model. [Int J Mol Sci] Full Article

Transcriptional Suppression of Androgen Receptor by 18β-Glycyrrhetinic Acid in LNCaP Human Prostate Cancer Cells

Researchers report the novel mechanisms by which 18β-glycyrrhetinic acid targets androgen receptor to stimulate cell death in both hormone-responsive and hormone-refractory prostate cancer cells. [Arch Pharm Res] Abstract

PKMYT1 Is Associated with Prostate Cancer Malignancy and May Serve as a Therapeutic Target

Functional studies demonstrated that knockdown of PKMYT1 significantly inhibited the growth of prostate cancer cells. Further investigation illustrated that PKMYT1 promoted the growth of prostate cancer cells through targeting CCNB1 and CCNE1 expression. [Gene] Abstract

Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells

Metastatic potentials of ALDH^hi cancer stem cells (CSCs) and ALDH^low non-CSCs were analyzed in zebrafish. [Cells] Full Article

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Anticancer Properties and Mechanism of Action of the Quassinoid Ailanthone

The author focuses on the mechanism of action of ailanthone, notably to highlight the capacity of the drug to activate DNA damage responses, to inhibit the Hsp90 co-chaperone p23 and to modulate the expression of several microRNA. [Phytother Res] Abstract

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Nubeqa^® (Darolutamide) Receives EU Approval as a New Treatment for Men with Non-Metastatic Castration-Resistant Prostate Cancer

The European Commission has granted marketing authorisation in the European Union (EU) for Nubeqa^®, an oral androgen receptor inhibitor. The approval is based on Phase III ARAMIS trial results showing a statistically significant improvement in metastasis-free survival for darolutamide plus androgen deprivation therapy (ADT) versus placebo plus ADT, and a favorable safety profile. [Orion Corporation] Press Release

Myriad Seeks Japanese Regulatory Approval for its BRACAnalysis^® Diagnostic System in People with Advanced Pancreatic and Prostate Cancer

Myriad Genetics, Inc. announced it has submitted a supplementary application with the Japanese Ministry of Health Labour and Welfare for its BRACAnalysis^® Diagnostic System to be used as a companion diagnostic to help to identify people with metastatic pancreatic or metastatic castration-resistant prostate cancer who have germline BRCA1 and BRCA2 mutations. [Myriad Genetics, Inc.] Press Release

Female Scientists Allege Discrimination, Neglect of Research on Women at NIH’s Child Health Institute

In November 2014, nine senior female scientists at the National Institute of Child Health and Human Development requested a meeting with their director. Their concern: that the careers of women at the institute’s Division of Intramural Research were being stymied by its powerful scientific director, Constantine Stratakis. [ScienceInsider] Editorial

Americans Are Underestimating How Long Coronavirus Disruptions Will Last, Health Experts Say

Public health experts are increasingly worried that Americans are underestimating how long the coronavirus pandemic will disrupt everyday life in the country, warning that the Trump administration’s timelines are offering many a false sense of comfort. [STAT News] Editorial

Coronavirus Will Transform UK Work and Travel, Says AA

The aftermath of the Covid-19 crisis will transform the way we live, work and travel in the UK, the AA says. It predicts a permanent reduction in the demand for travel because people have learned during the crisis to use home-working technology. The implications are profound for commuters and for government finances. [BBC News] Editorial

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NEW Postdoctoral Associate – Urology Cancer Related Research (University of Miami Health System)

Postdoctoral Associate – Leydig Stem Cell Research (University of Miami Health System)

Postdoctoral Studentship – RNA-Dependent Proteins in Cancer Cell Mitosis (German Cancer Research Center in the Helmholtz Association)

Associate Professor – Cancer Biology (University of Cincinnati)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Position – Cancer Cell Biology and Drug Discovery (University of Luxembourg)

Postdoctoral Research Fellow – Molecular Oncology (Genentech)

Postdoctoral Fellow – Solid Tumor Microenvironment Research (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Prostate Cancer (University of Washington)

Head – Single Cell Research (Sloan Kettering Institute)

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