Pulmonary Cell News 8.13 April 11, 2019 | |
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TOP STORYLung Cancer Deficient in the Tumor Suppressor GATA4 Is Sensitive to TGFBR1 Inhibition Through the genome-wide screening of tumor-suppressive transcription factors, researchers demonstrated that GATA4 functioned as an essential tumor suppressor in lung cancer in vitro and in vivo. Ectopic GATA4 expression resulted in lung cancer cell senescence. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Lipopolysaccharide from phosphorylcholine (ChoP)-positive bacteria induced NLRP3 and caspase-1 proteins in human alveolar epithelial cells, however antagonism of platelet activating factor receptor (PAFR) prevented NLRP3 activation by ChoP. Amoxicillin reduced bacterial populations in the lungs and reduced NLRP3 inflammasome protein levels, but did not reduce PAFR. [Mucosal Immunol] Abstract Although liposomes could permanently entrap a large fraction of actives, they could not sustain their release in vitro. Liposomes made of dioleoyltrimethylammoniumpropane were safe to respiratory cells in vitro while liposomes composed of dimethylaminoethanecarbamoyl-cholesterol were cytotoxic. [Mol Pharm] Abstract Polarized AAVR Expression Determines Infectivity by AAV Gene Therapy Vectors Scientists found adeno-associated virus receptor (AAV) receptor (AAVR) in human airway epithelia by western blot and RNA-Seq analyses. Using immunocytochemistry, they did not find endogenous AAVR at membranes but overexpression localized AAVR to the basolateral membrane, where it preferentially increased transduction. [Gene Ther] Abstract LUNG CANCERScientists showed that long noncoding RNA (lncRNA) NORAD was downregulated in lung and breast cancers, and that NORAD low expression in these cancer types was associated with lymph node metastasis and poor prognosis. NORAD was transcriptionally repressed by the Hippo pathway transducer YAP/TAZ-TEAD complex in conjunction with the action of NuRD complex. [Oncogene] Abstract JMJD2 Promotes Acquired Cisplatin Resistance in Non-Small Cell Lung Carcinoma Cells Investigators screened gene expression of known histone methyltransferases and demethylases in three non-small-cell lung carcinoma (NSCLC) cell lines with or without acquired resistance to cisplatin (CP). They found expression of several JMJD2 family genes upregulated in CP-resistant cells, with JMJD2B expression being upregulated in all three CP-resistant NSCLC cell lines. [Oncogene] Full Article The authors found elevated levels of interleukin 35 (IL-35) in the tumoural (TU) region as well as postoperative serum from patients with lung adenocarcinoma. Consistently, they found increased expression of IL-35+Foxp-3+ cells, which associated with ARG1 mRNA expression and decreased TNFA in the TU region of the lung of patients with non-small cell lung cancer as compared to their control region. [Br J Cancer] Full Article Toxicodendron vernicifluum (Tv)-silver nanoparticles (AgNPs) at the concentration of 320 µg.mL-1 induced 82.5% of cell death in human lung cancer, A549 cells and further 95% of cell death with annexin V FITC/PI based apoptosis. The Tv-AgNPs selectively targeted and damaged the cancer cells through ROS generation. [Sci Rep] Full Article Scientists showed that PCC0208027 effectively inhibited the enzyme activity of epidermal growth factor receptor (EGFR) family members, including drug-sensitive EGFR mutations, acquired drug-resistant EGFR T790M and EGFR C797S mutations, and wild-type HER2. [Sci Rep] Full Article With miRNA-seq analysis, the authors found that miR-147b was the most upregulated microRNA in osimertinib-tolerant and epidermal growth factor receptor (EGFR)-mutated lung cancer cells. Whole-transcriptome analysis of single-cell-derived clones revealed a link between osimertinib tolerance and pseudohypoxia responses irrespective of oxygen levels. [Nat Metab] Abstract | Press Release Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSMicrobes, Metabolites, and the Gut-Lung Axis The authors review the current understanding of host-microbe cross-talk along the gut-lung axis. They highlight the importance of short-chain fatty acids in shaping and promoting bone marrow hematopoiesis to resolve airway inflammation and to support healthy homeostasis. [Mucosal Immunol] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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SCIENCE NEWSBayer presented subgroup analysis data of patients with non-small cell lung cancer with neurotrophic receptor tyrosine kinase (NTRK) gene fusion treated with larotrectinib. [Press release from Bayer (PR Newswire Association LLC) discussing research presented at the 2019 European Lung Cancer Congress (ELCC), Geneva] Press Release aTyr Pharma, Inc. announced that the company will present an abstract in a poster presentation. [Press release from aTyr Pharma, Inc. discussing research to be presented at the American Thoracic Society (ATS) 2019 International Conference, Dallas] Press Release | |
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INDUSTRY NEWSSynspira Therapeutics announced that the European Medicines Agency Committee for Orphan Medicinal Products has granted orphan drug designation to the company’s lead product, SNSP113, a first-in-class glycopolymer, for the treatment of people with cystic fibrosis. [Synspira Therapeutics] Press Release Verona Pharma Granted Key EU Patent Related to Late-Stage COPD Clinical Candidate Ensifentrine Verona Pharma plc announced that the European Patent Office has recently granted an additional key patent relating to its lead development candidate, ensifentrine. [Verona Pharma plc] Press Release Pliant Therapeutics, Inc. announced the successful completion of its first-in-human clinical study of its lead product candidate, PLN-74809. [Pliant Therapeutics, Inc.] Press Release Neon Therapeutics, Inc. announced the completion of enrollment in NT-002, its Phase Ib clinical trial evaluating NEO-PV-01 with pembrolizumab and chemotherapy in patients with untreated advanced or metastatic non-small cell lung cancer. [Neon Therapeutics, Inc.] Press Release Paul Andrew Reyfman, MD, MS, of Northwestern University has been awarded the ATS Foundation/Boehringer Ingelheim Pharmaceuticals, Inc. Research Fellowship in idiopathic pulmonary fibrosis. The $100,000 award will help fund Dr. Reyfman’s research, “Single Cell Transcriptomic Analysis of Pulmonary Fibrosis.” [ATS Foundation (EurekAlert!)] Press Release Two of the most effective and influential nonprofit organizations serving the lung cancer community, the Bonnie J. Addario Lung Cancer Foundation and Lung Cancer Alliance announced they are joining forces as the GO2 Foundation for Lung Cancer. [GO2 Foundation for Lung Cancer (PR Newswire Association LLC)] Press Release | |
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POLICY NEWSImpact Factors Are Still Widely Used in Academic Evaluations About 40% of institutes with a strong focus on research mention impact factors in documents used in the review, promotion and tenure process, according to the analysis, which examined more than 800 documents across 129 institutions in the United States and Canada. [Nature News] Editorial FDA, New York Attorney General Go After Stem Cell Clinics On April 3, the FDA sent letters to 20 companies providing stem cell treatments, reports The New York Times, reminding them that they may require FDA approval and should take action to comply. The agency also issued a warning to a stem cell company for violating good manufacturing practices. [The Scientist] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Early Stage Researcher – Lung Organoid Culture (STEMCELL Technologies Inc.) Scientist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Position – Lung Research (Columbia University) Postdoctoral Scholar – Acute Respiratory Distress Syndrome (University of California, San Francisco) Molecular Biologist (Entrinsic Health Solutions, Inc.) Research Associate – Gene Therapy for Cystic Fibrosis (Imperial College London) Postdoctoral Position – Stem Cells, Regenerative Biology and Medicine (Helmholtz Zentrum München) Associate Professor – Primary Ciliary Dyskinesia (University of Southampton) Postdoctoral Fellow – Lung Disease (Icahn School of Medicine at Mount Sinai) Assistant/Associate/Full Professor – Lung Cancer (University of Cincinnati College of Medicine) Associate Professor – Oncology (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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