Pulmonary Cell News Volume 9.09 | Mar 12 2020

TOP STORY

CRISPR Screens in Cancer Spheroids Identify 3D Growth-Specific Vulnerabilities

Investigators devised a scalable cancer-spheroid model and performed genome-wide CRISPR screens in 2D monolayers and 3D lung-cancer spheroids. [Nature] Abstract

(Ranked by impact factor of the journal)

Identification of Sca-1⁺Abcg1⁺ Bronchioalveolar Epithelial Cells as the Origin of Lung Adenocarcinoma in Gprc5a-Knockout Mouse Model through the Interaction between Lung Progenitor AT2 and Lgr5 Cells

Scientists proposed a new therapeutic strategy: investigating the “transitional” cells that represented the stage between normal lung stem cells and lung cancer stem cells. [Oncogene] Full Article

TRPC6-Dependent Ca²⁺ Signaling Mediates Airway Inflammation in Response to Oxidative Stress via ERK Pathway

In vitro, both knockdown of canonical transient receptor potential channel 6 (TRPC6) expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O₃ or H₂O₂ in human bronchial epithelial cell lines. [Cell Death Dis] Full Article

LUNG CANCER

Extracellular Vesicle Tetraspanin-8 Level Predicts Distant Metastasis in Non-Small Cell Lung Cancer After Concurrent Chemoradiation

Researchers used proteomics to identify proteins differentially expressed on extracellular vesicles (EVs) of nonmetastatic 393P and metastatic 344SQ non-small cell lung cancer cell lines and found that tetraspanin-8 was selectively enriched on 344SQ EVs. [Sci Adv] Full Article

Tumor Progression and Chromatin Landscape of Lung Cancer Are Regulated by the Lineage Factor GATA6

In lung adenocarcinoma cells derived from surfactant protein C expressing progenitors, investigators identified multiple genomic loci that were bound by GATA6. [Oncogene] Full Article

MCL1 Inhibition Is Effective against a Subset of Small-Cell Lung Cancer with High MCL1 and Low BCL-XL Expression

Researchers used S63845, a MCL1 inhibitor, to assess the cytotoxic capacity in small-cell lung cancer cell lines including a patient-derived cell line in vitro and in vivo. [Cell Death Dis] Full Article

Mitochondrial Division Inhibitor (Mdivi-1) Decreases Oxidative Metabolism in Cancer

Metabolic isotope tracing found that mdivi-1 decreased mitochondrial oxidative metabolism in the lung cancer cell lines H460 and A549, and the colon cancer cell line HCT116. [Br J Cancer] Full Article

Precision-Engineered Reporter Cell Lines Reveal ABCG2 Regulation in Live Lung Cancer Cells

Scientists describe a fluorescent reporter assay that allowed the noninvasive assessment of ABCG2 regulation in human lung adenocarcinoma cells. [Biochem Pharmacol] Full Article | Graphical Abstract

In Vitro Evaluation of Copper/Copper Oxide Nanoparticles Cytotoxicity and Genotoxicity in Normal and Cancer Lung Cell Lines

Evaluation of the toxicity of copper/copper oxide nanoparticles was performed on two types of cells: human lung normal cell lines and human lung carcinoma cell. [J Trace Elem Med Biol] Abstract

3D Microgroove Electrical Impedance Sensing to Examine 3D Cell Cultures for Antineoplastic Drug Assessment

A microgroove impedance sensor was specially developed for the dynamic and noninvasive monitoring of 3D cell viability. 3D cancer cells were trapped in microgrooves with gold electrodes on opposite walls for in situ impedance measurement. [Microsyst Nanoeng] Abstract

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Acquired Resistance to Targeted Therapies in NSCLC: Updates and Evolving Insights

The authors provide a broad overview of the mechanisms of resistance to targeted therapy that have been demonstrated across molecular subtypes of non-small cell lung cancer (NSCLC). [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

CytoDyn Files IND and Protocol for Phase II Clinical Trial for Treatment of Coronavirus Patients with Leronlimab (PRO 140)

CytoDyn Inc. announced that the company has submitted an investigational new drug application to the FDA to conduct a Phase II clinical trial with leronlimab as a therapy for patients who experience respiratory complications as a result of contracting the coronavirus disease 2019. [CytoDyn Inc.] Press Release

Algernon Scales up Manufacturing of NP-120 (Ifenprodil) to Prepare for Coronavirus and Acute Lung Injury US Clinical Trials

Algernon Pharmaceuticals, Inc. announced that it has made the decision to begin production of NP-120 with a new injectable and long acting oral release formulation, in order to be prepared for new US clinical trials for COVID-19 and acute lung injury. [Algernon Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release

Universities Are Forging Ties with the FBI as US Cracks Down on Foreign Influence

US universities are forging closer ties with FBI agents, encouraging scientists to disclose foreign sources of research funding, and tightening restrictions on researchers’ travel. [Nature News] Editorial

Hundreds of Scientists Have Peer-Reviewed for Predatory Journals

Hundreds of scientists who post their peer-review activity on the website Publons say they’ve reviewed papers for journals termed ‘predatory’, an analysis has found. The site hosts at least 6,000 records of reviews for more than 1,000 predatory journals. [Nature News] Editorial

NEW American Thoracic Society Conference
May 15-20, 2020
Philadelphia, Pennsylvania, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Lung Organoids (Columbia University Medical Center)

NEW Postdoctoral Research Associate – Lung Injury (University of Illinois at Chicago)

Research Associate – Cystic Fibrosis (Michigan State University)

Research Associate – Lung Tumors (University of Cambridge)

Research Associate and Lab Manager – In Vitro Cancer Models (Flanders Institute for Biotechnology)

Postdoctoral Scholar – Cancer Metabolism (The Ohio State University)

Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center)

Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California, San Francisco)

Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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