Cancer Stem Cell News Volume 9.05 | Feb 12 2020

TOP STORY

CD73 Sustained Cancer-Stem-Cell Traits by Promoting SOX9 Expression and Stability in Hepatocellular Carcinoma

A sphere-forming assay was performed to evaluate cancer stem cell traits in vitro, subcutaneous NOD/SCID mice models were generated to assess in vivo cancer stem cell features, and colony formation assays assessed drug resistance capacities. [J Hematol Oncol] Full Article

(Ranked by impact factor of the journal)

Pin2 Telomeric Repeat Factor 1-Interacting Telomerase Inhibitor 1 (PinX1) Inhibits Nasopharyngeal Cancer Cell Stemness: Implication for Cancer Progression and Therapeutic Targeting

Cell Counting Kit-8, Transwell assays, colony formation analysis and xenograft tumorigenicity assay were used to measure the nasopharyngeal CD133⁺ cancer stem cell proliferation, migration, and invasion abilities. [J Exp Clin Cancer Res] Full Article

SIRT1 Inhibits Chemoresistance and Cancer Stemness of Gastric Cancer by Initiating an AMPK/FOXO3 Positive Feedback Loop

Scientists observed a suppressive role of SIRT1 in chemoresistance of gastric cancer both in vitro and in vivo. They found that SIRT1 eliminated cancer stem cell properties of gastric cancer cells. [Cell Death Dis] Full Article

GATA6 Enhances the Stemness of Human Colon Cancer Cells by Creating a Metabolic Symbiosis through Upregulating LRH-1 Expression

Researchers identified the downstream mediators of the stemness-stimulating effect of GATA6. LRH-1 was found as a direct target of GATA6 and its upregulation promoted the stemness in both HC-116 and HT-29 cells. [Mol Oncol] Abstract

Adipose-Derived Stem Cells and Cancer Cells Fuse to Generate Cancer Stem Cell-Like Cells with Increased Tumorigenicity

The authors found that adipose-derived stem cells fused with breast cancer cells spontaneously, while breast cancer stem cell markers CD44⁺CD24^-/lowEpCAM⁺ were enriched in this fusion population. [J Cell Physiol] Abstract

Fibroblasts-Dependent Invasion of Podoplanin-Positive Cancer Stem Cells in Squamous Cell Carcinoma

A collagen gel invasion assay was performed using fluorescent ubiquitination-based cell cycle indicator-labeled A431 cells. The total number and number of invading cells in S/G2/M phase were counted using time-lapse imaging cocultured with fibroblasts. [J Cell Physiol] Abstract

3D Tumor Spheroids for the Prediction of the Effects of Radiation and Hyperthermia Treatments

The response of tumor spheroids formed from two established human cancer cell lines to single and combination treatments of radiation, and hyperthermia at 47°C was evaluated. [Sci Rep] Full Article

TNF-α Increases Breast Cancer Stem-Like Cells through Up-Regulating TAZ Expression via the Non-Canonical NF-κB Pathway

Investigators demonstrated that tumor necrosis factor alpha (TNF-α) up-regulated TAZ, a transcriptional co-activator promoting breast cancer stem-like cell self-renewal capacity in human breast cancer cell lines. [Sci Rep] Full Article

Human Fallopian Tube Epithelial Cells Exhibit Stemness Features, Self-Renewal Capacity, and Wnt-Related Organoid Formation

Sphere formations on gelatin-coated culture, suspension culture, and matrigel culture were observed, and the expression of LGR5, SSEA3, SSEA4, and other stemness markers was examined. [J Biomed Sci] Full Article

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Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells

The authors discuss how post-transcriptional mechanisms enable stem cell homeostasis and responsiveness to developmental cues and environmental stressors by rapidly shaping the content of their proteome and how these processes are disrupted in pre-malignant and malignant states. [Cell Stem Cell] Abstract

Crosstalk between Autophagy and Metabolic Regulation of Cancer Stem Cells

Scientists emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. [Mol Cancer] Full Article

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US FDA Grants Priority Review for Kite’s KTE-X19 Biologics License Application (BLA) in Relapsed or Refractory Mantle Cell Lymphoma

Kite announced that the FDA has accepted the BLA and granted Priority Review designation for KTE-X19, an investigational chimeric antigen receptor T cell therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma. [Kite (Business Wire, Inc.)] [Kite (Business Wire, Inc.)] Press Release

Astex Pharmaceuticals Announces US FDA Acceptance for Review of an NDA for the Combination Oral Hypomethylating Agent Cedazuridine and Decitabine (ASTX727 or Oral C-DEC), for the Treatment of MDS and CMML

Astex Pharmaceuticals, Inc. announced that the FDA has accepted for Priority Review its NDA for oral C-DEC as a treatment for adults with previously untreated intermediate- and high-risk myelodysplastic syndromes (MDS) including chronic myelomonocytic leukemia (CMML). [Astex Pharmaceuticals, Inc (Business Wire, Inc.)] Press Release

Trump Proposes Significant Cuts to NIH for 2021 Budget

The president’s request for next year’s federal budget includes a seven percent drop in funding for the National Institutes of Health and reductions for other science agencies. [The Scientist] Editorial

Major Cancer Institute Sued by Its Own Researchers over ‘Tapering’ Funding

Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego, have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial

NEW Tumor Metabolism
March 8-12, 2020
Banff, Alberta, Canada

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NEW Postdoctoral Research Fellowship _ Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Research Fellow – Glioblastoma Cell Signaling (University of Sussex)

Postdoctoral Associate – Leukemia and Brain Tumors (Ann and Robert H. Lurie Children’s Hospital of Chicago)

Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

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