Cord Blood News 8.33 August 25, 2016 | |
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TOP STORYGiven the frequent HLA-class II allele mismatches between cord blood unit (CBU) in dUCBT, researchers hypothesized that alloreactive HLA-class II-specific CD4+ T-cells from the ‘winning’ CBU may contribute to rejection of the ‘loser’ CBU. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors evaluated if the up-regulation of vascular endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a renal ischemia-reperfusion injury model. [Crit Care Med] Abstract Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescence Researchers hypothesized that the bioactive factors secreted by mesenchymal stem cells (MSC) isolated from human fetal tissues (hFMSC), collectively named as hFMSC secretome, could possess beneficial effects on human adult MSC undergoing replicative senescence, thus promoting their capability of proliferation and differentiation. [Stem Cells Dev] Abstract Scientists used combinatorial cell culture technology (CombiCult®) to identify media formulations that promote CD133+ cord blood hematopoietic stem/progenitor cells proliferation while maintaining their phenotypic characteristics. [Stem Cells Dev] Abstract Human Mesenchymal Stromal Cells Modulate T-Cell Immune Response via Transcriptomic Regulation By using a microarray-based global gene expression profiling system, scientists aimed to decipher the underlying molecular pathways that may mediate the immunosuppressive activity of umbilical cord-derived mesenchymal stromal cells on activated T cells. [Cytotherapy] Abstract Investigators evaluated the effects of retinoic acid-pretreated Wharton’s jelly mesenchymal stem cells in combination with triiodothyronine in the ischemia stroke model. [Metab Brain Dis] Abstract Implementing a Routine Flow Cytometry Assay for Nucleated Red Blood Cell Counts in Cord Blood Units The authors present the validation and implementation approaches developed to transfer the routine nucleated red blood cells enumeration from the manual blood film method to a flow cytometric assay. [Int J Lab Hematol] Abstract Rotavirus Activates Dendritic Cells Derived from Umbilical Cord Blood Monocytes Scientists determined the response of monocyte-derived dendritic cells from umbilical cord blood and adult peripheral blood to rotavirus in vitro. [Microb Pathog] Abstract | |
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REVIEWSMesenchymal Stem Cell: A New Horizon in Cancer Gene Therapy The authors highlight various applications of mesenchymal stem cells in cancer gene therapy. [Cancer Gene Ther] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTulane Professor Receives Grant to Improve Stem Cell Survival Kim O’Connor, a professor in Tulane University’s Department of Chemical and Biomolecular Engineering, received a three-year $599,638 grant from the National Science Foundation to study ways to improve the survival of mesenchymal stem cells once they are implanted in patients. [Tulane University] Press Release Genmab A/S announced that its licensing partner, Janssen Biotech, Inc. has submitted a supplemental Biologics License Application to the U.S. Food and Drug Administration (FDA) for the use of daratumumab in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of patients with multiple myeloma who received at least one prior therapy. [Genmab A/S] Press Release MolMed S.p.A. announced that the European Commission has granted a Conditional Marketing Authorization for Zalmoxis, the first immunogene therapy, as patient-specific adjunctive treatment in haplo-identical hematopoietic stem-cell transplantation for adult patients with high-risk hematological malignancies. [MolMed S.p.A.] Press Release | |
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POLICY NEWSObama’s Science Legacy: Uneven Progress on Scientific Integrity Many researchers who watched Barack Obama’s inauguration in 2009 were thrilled by his pledge to “restore science to its rightful place”. But scientists and legal scholars say that, in many ways, Obama has failed to live up to that lofty promise. [Nature News] Editorial Mouse Microbes May Make Scientific Studies Harder to Replicate Experimenters are questioning the potential research impact of the microbiome—a term often used to refer to commensal gut bacteria, but which also includes resident viruses, fungi, protozoa, and single-celled archaea species. [Science] Editorial Putin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2016 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Cancer Biology (University of Michigan) Technical Sales Representative (STEMCELL Technologies Inc.) Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California) Postdoctoral Position – Cancer Genomics (Ohio State University) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Cell Biologist – Mesenchymal Stem Cells (Biostage) PhD Studentship – Various Projects (Vienna Biocenter) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.33 | Aug 25 2016