Cord Blood News Volume 12.18 | May 14 2020

TOP STORY

The Quality Evaluation System Establishment of Mesenchymal Stromal Cells for Cell-Based Therapy Products

Investigators established a safety evaluation system for therapeutic stromal cells based on the existing regulations and current testing techniques to provide general quality requirements for human umbilical cord MSC therapy product. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Cord Blood-Endothelial Colony Forming Cells Are Immunotolerated and Participate at Post-Ischemic Angiogenesis in an Original Dorsal Chamber Immunocompetent Mouse Model

Scientists demonstrated that cord blood-endothelial progenitor cell-derived endothelial colony forming cells (CB-ECFCs) expressed HLA-G, IL-10, and TGF-β1 and secreted IL-10 and TGF-β1 and that they could display immunosuppressive properties in vitro. CB-ECFCs could be tolerated until 14-days in immunocompetent mice. [Stem Cell Res Ther] Full Article

Human Cord Blood-Derived Regulatory T-Cell Therapy Modulates the Central and Peripheral Immune Response after Traumatic Brain Injury

The authors demonstrated that human umbilical cord blood regulatory T cells modulated the central and peripheral immune response after injury in vitro and in vivo. [Stem Cells Transl Med] Full Article

Cytokine Physiognomies of MSCs from Varied Sources Confirm the Regenerative Commitment Post‐Coculture with Activated Neutrophils

Researchers compared MSCs from the umbilical cord blood, dental pulp, and liposuction material on their ability to respond to activated neutrophils. [J Cell Physiol] Abstract

Cotransplantation of Human Umbilical Cord Mesenchymal Stem Cells and Endothelial Cells for Angiogenesis and Pulp Regeneration In Vivo

Cocultured human umbilical cord MSCs (hUCMSCs) and human umbilical vein endothelial cells (HUVECs) promoted vascular formation of HUVECs, and the optimal coculture ration was 1:5 (hUCMSCs:HUVECs). hUCMSCs promoted angiogenesis of HUVECs through the long noncoding RNA HIF1A-AS2-activation of the Hif-1 signaling pathway. [Life Sci] Abstract

Cloning of Human Cord Blood-Mesenchymal Stem Cells for Isolation of Enriched Cell Population of Higher Proliferation and Differentiation Potential

Cloning of MSCs was attainable when cultured in mouse embryonic fibroblast conditioned media. Single clones with higher proliferation and differentiation potential than their original progenitor cells were obtained by cloning of poorly functioning MSCs progenitor cells, enabling the selection of more therapeutically efficacious MSCs with better performance in clinical applications. [Mol Biol Rep] Abstract

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Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Scientists address the immunomodulatory properties and immunosuppressive actions of MSCs. They also sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes. [Cells] Full Article

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Ascentage Pharma’s Core Drug Candidate HQP1351 Granted Fast Track Designation by the US FDA, Marking Another Milestone in Its Development

Ascentage Pharma announced that the FDA has granted HQP1351, the company’s core drug candidate, a Fast Track Designation for the treatment of patients with chronic myeloid leukemia with certain genetic mutations who have failed to respond to treatments with existing tyrosine kinase inhibitors. [Ascentage Pharma] Press Release

Scientists Are Drowning in COVID-19 Papers. Can New Tools Keep Them Afloat?

Backed by large technology firms and the White House, a loose-knit army of data scientists, software developers, and journal publishers are racing to create digital collections holding thousands of freely available papers that could be useful to ending the pandemic, and scrambling to build data-mining and search tools that can help researchers quickly find the information they seek. [ScienceInsider] Editorial

House Democrats Include Research Dollars in Latest Pandemic Relief Package

For US scientists, the good news is that the $3 trillion spending bill unveiled contains billions of dollars in new research funding. The bad news is that the bill is only a marker for negotiations with Senate Republicans and the White House on what more the federal government should do to help the country deal with the devastating economic and health effects of the pandemic. [ScienceInsider] Editorial

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NEW Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

NEW Head – Hematological Cancer (Ichnos)

Deputy Director – Division of Blood Diseases and Resources (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Senior Scientist – Cell Engineering (Merck & Co., Inc.)

Project Manager – Precision Medicine (Prinses Máxima Centrum)

Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute)

Director – Blood Research Institute (Versiti)

Postdoctoral Positions – Leukemia (Temple University School of Medicine)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

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