| Vol. 6.23 – 29 June, 2020 |
| |
|
|
| Using a novel in-vitro 3D human adipocyte/pre-adipocyte spheroid model, researchers investigated whether adipocytes and their precursors secreted factors that affected human dermal fibroblast behavior. [Scientific Reports] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
| | Scientists investigated whether the anti-inflammatory activities of aspirin (ASA) could protect against UVB-induced DNA damage and skin carcinogenesis. ASA reduced UVB-induced 8-oxoguanine and cyclobutane pyrimidine dimers in Melan-a melanocytes and HaCat keratinocytes. [Journal of investigative Dermatology] |
| | It was demonstrated that the tannic acid-treated methacrylated chitosan/methacrylated silk fibroin hydrogels could significantly promote wound healing in a full-thickness skin defect model. [Carbohydrate Polymers] |
| | 4% sodium alginate hydrogel coupled with honey treated wound closure achieved epithelial thickness resembling that of unwounded skin. [Materials Science & Engineering C-Materials For Biological Applications] |
| | The biocompatibility of three new PEGylated phenothiazine derivatives was assessed on normal human dermal fibroblasts and human cervical cancer cells. The synthetized compounds showed the formation of luminescent aggregates and proved excellent biocompatibility on normal cells. [Materials Science & Engineering C-Materials For Biological Applications] |
| | Inspired by the strong adhesive mechanism of biofilm and mussels, researchers report a novel dual bionic adhesive hydrogel (DBAH) based on chitosan grafted with methacrylate, dopamine, and N-hydroxymethyl acrylamide. DBAH showed promise to provide a novel method for visceral hemostasis and accelerated healing of cutaneous skin wounds. [Bioactive Materials] |
| |
|
|
| The authors designed PEGylated lipid nanocarriers loaded with curcumin (cur) to target skin cancer by photodynamic therapy. Cur is a polyphenolic compound having vast biological effects masked due to its low aqueous solubility. [Scientific Reports] |
|
|
|
| Researchers performed shallow single-cell sequencing of genomic DNA across 1475 cells from a melanoma cell-line, COLO829 (a benchmark for evaluating somatic alterations) to resolve overall complexity and clonality. [Communications Biology] |
|
|
|
|
| The authors highlight the roles of kallikreins in skin homeostasis and pathologies. Due to their part in these skin disorders, inhibitors of the skin kallikreins have become attractive therapeutics. [Critical Reviews in Clinical Laboratory Sciences] |
|
|
|
| Scientists discuss the evidence showing the crucial role of hypoxia-inducible factor-1α in psoriasis along with interrelationship with other mediators/signaling pathways that may contribute to the development of psoriasis. [International Immunopharmacology] |
|
|
|
|
| AiViva Biopharma Inc., has announced completion of its first Phase I/IIa study evaluating AIV001 in dermal scarring. A total of 16 subjects who were scheduled to undergo abdominoplasty were enrolled and completed in one of the four double-blind dose escalation or open label cohorts. [AiViva BioPharma] |
|
|
|
| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs. [Nature News] |
|
|
|
|
| July 13 – July 16 Virtual |
|
|
|
|
| | King’s College London – London, United Kingdom |
|
|
|
| Netherlands Cancer Institute – Amsterdam, Netherlands |
|
|
|
| Bristol Myers Squibb – Montréal, Quebec, Canada |
|
|
|
| The Hormel Institute – Austin, Minnesota, United States |
|
|
|
| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
|
|
|
|