Hepatic Cell News Volume 4.19 | May 29 2020

TOP STORY

Hepatic NADH Reductive Stress Underlies Common Variation in Metabolic Traits

Scientists demonstrated that NADH reductive stress mediated the effects of GCKR variation on many metabolic traits, including circulating triglyceride levels, glucose tolerance and FGF21 levels. [Nature] Abstract

(Ranked by impact factor of the journal)

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

The authors provided proof-of-concept for the repurposing of a previously intolerable medication to address unmet needs in the clinical landscape for obesity-induced type 2 diabetes mellitus and nonalcoholic steatohepatitis. [ACS Nano] Abstract

N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell Culture-Generated Hepatitis B Virus

Researchers used a system to provide a powerful tool for studying the infection and propagation of hepatitis B virus (HBV) in cell culture, and also for developing the anti-viral strategy against HBV infection. [Hepatology] Abstract

YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells

YAP1^S127A withdrawal, without silencing oncogenic β-Catenin, significantly regressed hepatoblastoma, providing the first in vivo data to support YAP1 as a therapeutic target for hepatoblastoma. [Hepatology] Abstract

APN-Mediated Phosphorylation of BCKDK Promotes Hepatocellular Carcinoma Metastasis and Proliferation via the ERK Signaling Pathway

Investigators found that aminopeptidase N (APN) might have mediated the phosphorylation at serine 31 of BCKDK, promoting BCKDK interacting with ERK1/2 and phosphorylating it, thereby activating the ERK signaling pathway in hepatocellular carcinoma cells. [Cell Death Dis] Full Article

Synergistic Antifibrotic Effects of miR-451 with miR-185 Partly by Co-Targeting EphB2 on Hepatic Stellate Cells

Scientists indicated that miR-451 and miR-451/XPO-1/miR-185 axis played important and synergistic regulatory roles in hepatic fibrosis partly through co-targeting EphB2 [Cell Death Dis] Full Article

Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders

The authors report on a novel design with improved activity and stability compared to a triantennary design. They applied a versatile monovalent serinol-GalNAc conjugation strategy. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

Sox13 Promotes Hepatocellular Carcinoma Metastasis by Transcriptionally Activating Twist1

Scientists revealed the clinical significance and biological function of Sox13 in hepatocellular carcinoma (HCC). The expression of Sox13 in HCC samples was evaluated by qRT-PCR and western blotting, and its association with clinicopathological features and prognosis was determined. [Lab Invest] Abstract

lncRNA-SOX2OT Promotes Hepatocellular Carcinoma Invasion and Metastasis through miR-122-5p-Mediated Activation of PKM2

Investigators observed that a long noncoding RNA-SOX2OT (lncRNA-SOX2OT) not only increased the metastatic potential of hepatocellular carcinoma but also promoted a pyruvate kinase M2 (PKM2)-mediated activation of glucose metabolism. [Oncogenesis] Full Article

Genetic Dissection of Rift Valley Fever Pathogenesis: Rvfs2 Locus on Mouse Chromosome 11 Enables Survival to Early-Onset Hepatitis

The authors used BALB/cByJ mice congenic for Rvfs2 to investigate the pathophysiological mechanisms impacted by Rvfs2. They indicated that Rvfs2 controlled critical events which allowed survival to RVFV-induced hepatitis. [Sci Rep] Full Article

Gasdermin E-Derived Caspase-3 Inhibitors Effectively Protect Mice from Acute Hepatic Failure

Researchers not only identified two specific inhibitors of caspase-3 for investigating programmed cell death (PCD) but also shed light on novel lead compounds for treating liver failure and organ dysfunctions caused by PCD. [Acta Pharmacol Sin] Abstract

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression

Scientists showed that LukS-PV inhibited cell proliferation and induced apoptosis in a concentration-dependent manner in hepatocellular carcinoma cell lines and also induced cell cycle arrest. [Mol Ther Oncolytics] Abstract | Graphical Abstract

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The Signaling and Functional Role of the Extracellular Matrix in the Development of Liver Fibrosis

The authors aimed to summarize and discuss the latest advances in the pathogenesis of liver fibrosis as well as key mediators of early disease progression. [Aliment Pharmacol Ther] Full Article

Recent Advances of Sterile Inflammation and Inter-Organ Cross-Talk in Alcoholic Liver Disease

Investigators summarize recent studies on the identification and understanding of damage-associated molecular patterns, their receptors, and cross-talk between the liver and other organs, highlighting successful therapeutic targets. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the hepatic cell research field.

Vir Biotechnology Initiates Phase I Clinical Trial of VIR-3434 for Chronic Hepatitis B Virus Infection

Vir Biotechnology, Inc. have announced the initiation of a Phase I clinical trial of VIR-3434, an investigational monoclonal antibody that neutralizes hepatitis B virus and has been engineered to potentially also act as a therapeutic vaccine. [Vir Biotechnology, Inc.] Press Release

What the Growing Rift Between the US and WHO Means for COVID-19 and Global Health

Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

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NEW Postdoc – Liver Pathophysiology (Ma Lab at University of Pittsburgh)

Assistant or Associate Professor – Pharmacology & Toxicology (University of Southern California)

Computational Analyst – Drug and Target Discovery (Human Liver Disease)

Postdoctoral Fellowships – Liver Research (The University of Hong Kong)

Postdoctoral Scientist – Quantitative Biology (Texas Biomedical Research Institute)

Research Scientist – Liver (Spark Therapeutics)

Staff Fellow – Viral Vaccines (FDA-Center for Biologics Evaluation and Research)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico Comprehensive Cancer Center)

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Scientist – Molecular & Cellular Biology (Deep Genomics, Inc.)

Postdoctoral Position – Gut-Liver Axis (University of California, Davis)

Therapuetic Specialist – Inflammation (Gilead Sciences Inc.)

Team Leader – Cholangiocytes (Miromatrix Medical)

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