Hepatic Cell News Volume 4.20 | Jun 5 2020

TOP STORY

Polymer-Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells

Polymer–lipid hybrid vesicles had no inherent cytotoxicity when incubated with HepG2 cells up to 1.1 × 10¹¹ hybrid vesicles per mL, and they were internalized by the cells. Scientists provided important insight into the design criteria of artificial organelles with potential structural integrity. [Small] Abstract

(Ranked by impact factor of the journal)

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human induced pluripotent stem cells in an organ-like environment, researchers generated functional engineered human mini-livers and performed transplantation in a rat model. [Cell Rep] Full Article | Graphical Abstract

Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice

Investigators aimed to test if three experimental conditions influenced AAV transgene expression in immunodeficient fumaryl acetoactetate hydrolase deficient (Fah^-/-) chimeric mice repopulated with primary human hepatocytes. [Mol Ther Methods Clin Dev] Abstract

TGF-β1-Mediated Repression of SLC7A11 Drives Vulnerability to GPX4 Inhibition in Hepatocellular Carcinoma Cells

Investigators found that transforming growth factor β1 (TGF-β1) repressed xCT expression via Smad3 activation and enhanced lipid peroxidation in hepatocellular carcinoma cells with an early TGF-β1 signature. [Cell Death Dis] Full Article

Long Noncoding RNA OIP5-AS1 Promotes the Progression of Liver Hepatocellular Carcinoma via Regulating Hsa-miR-26a-3p/EPHA2 Axis

The authors demonstrated that long noncoding RNA OIP5 antisense RNA 1 (OIP5-AS1) was up-regulated in liver hepatocellular carcinoma (LIHC) tissue specimens and its overexpression was associated with the poor survival of patients with LIHC. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

HDO Production from [²H₇]Glucose Quantitatively Identifies Warburg Metabolism

Researchers report a sensitive ¹H/²H NMR method to measure the kinetics of lactate isotopomer and HDO production using a deuterated tracer. Testing this, HUH-7 hepatocellular carcinoma and AML12 normal hepatocytes were incubated with [²H₇]glucose. [Sci Rep] Full Article

Hepatocytes Paradoxically Affect Intrahepatic Ifn-γ Production in Autoimmune Hepatitis Due to Gal-9 Expression and TLR2/4 Ligand Release

Researchers report that hepatocytes could secrete galectin-9 to suppress the intrahepatic production of Th1 cytokine IFN-γ and restrict autoimmune hepatitis development. [Mol Immunol] Full Article

Preemptive Homology-Directed DNA Repair Fosters Complex Genomic Rearrangements in Hepatocellular Carcinoma

Scientists assessed the relationship between DNA damage response (DDR) and chromosome instability in hepatocellular carcinoma (HCC). They investigated DDR signaling in HCC cells by analyzing DNA damage-dependent redistribution of major DDR proteins to damaged chromatin. [Transl Oncol] Full Article

Emodin Succinyl Ester Inhibits Malignant Proliferation and Migration of Hepatocellular Carcinoma by Suppressing the Interaction of AR and EZH2

The authors validated the therapeutic effect of emodin succinyl ester (ESE) on hepatocellular carcinoma (HCC) aggression by targeting the interaction of androgen receptor and enhancer of zeste homolog 2. [Biomed Pharmacother] Full Article | Graphical Abstract

Inhibition of EPS8L3 Suppresses Liver Cancer Progression and Enhances Efficacy of Sorafenib Treatment

Scientists suggested that EPS8L3 has pivotal oncogenic functions in liver cancer and proposed that EPS8L3 could be a potential therapeutic target to treat liver cancer, as its expression substantially increased the efficacy of low dosage Sorafenib treatment. [Biomed Pharmacother] Full Article | Graphical Abstract

MYB Proto-Oncogene Like 1-TWIST1 Axis Promote Growth and Metastasis of Hepatocellular Carcinoma Cells

Scientists found that the expression of MYB proto-oncogene like 1 (MYBL1) were markedly overexpressed in hepatocellular carcinoma (HCC) cell lines and HCC samples. MYBL1 expression positively correlated with tumor progression and inversely correlated with patient survival in 368 human HCC tissue samples. [Mol Ther Oncolytics] Abstract | Graphical Abstract

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Single-Cell Technologies in Hepatology: New Insights into Liver Biology and Disease Pathogenesis

The authors discuss how single-cell transcriptomic technologies have been applied in hepatology, advancing understanding of cellular heterogeneity and providing novel insights into fundamental liver biology such as the metabolic zonation of hepatocytes, endothelial cells and hepatic stellate cells. [Nat Rev Gastroenterol Hepatol] Abstract

Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease

Investigators review work on the pioneer factors and other chromatin remodelers that impact the gene expression patterns instructing hepatocyte and biliary cell specification and differentiation, along with the requirement of epigenetic regulatory factors for hepatic outgrowth. [Trends Genet] Abstract

Visit our reviews page to see a complete list of reviews in the hepatic cell research field.

FDA Approves Roche’s Tecentriq in Combination with Avastin for People with the Most Common Form of Liver Cancer

Roche has announced that the US FDA has approved Tecentriq^® in combination with Avastin^® for the treatment of people with unresectable or metastatic hepatocellular carcinoma who have not received prior systemic therapy. [F. Hoffmann-La Roche Ltd.] Press Release

IMFINZI Plus Tremelimumab Demonstrated Promising Clinical Activity and Tolerability in Patients with Advanced Liver Cancer

Results from the global Phase II Study 22 trial testing AstraZeneca’s tremelimumab, an anti-CTLA4 antibody and potential new medicine, added to IMFINZI^® demonstrated promising clinical activity and tolerability in patients with advanced hepatocellular carcinoma. [Business Wire Inc.] Press Release

NIH Grapples with Rush to Claim Billions in Pandemic Research Funds

For the second time in just over 10 years, the National Institutes of Health (NIH) is scrambling to hand out billions of dollars in emergency research funding and scientists are rushing to get a piece of the action, even as some confusion and concerns abound. [ScienceInsider] Editorial

As the Pandemic Hits Campus Finances, Faculty Face Layoffs

The pandemic has bored holes in budgets at universities and colleges across the US and beyond. To stem the spread of the coronavirus, higher education institutions shuttered their campuses, sent students home, and moved classes online. [The Scientist] Editorial

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NEW Postdoctoral Fellow – Liver Disease Macrophages (University of Kansas Medical Center)

NEW Postdoctural Researcher – Digestive and Liver Diseases (The University of Texas Southwestern Medical Center)

Postdoc – Liver Pathophysiology (Ma Lab at University of Pittsburgh)

Assistant or Associate Professor – Pharmacology & Toxicology (University of Southern California)

Computational Analyst – Drug and Target Discovery (Human Liver Disease)

Postdoctoral Fellowships – Liver Research (The University of Hong Kong)

Postdoctoral Scientist – Quantitative Biology (Texas Biomedical Research Institute)

Research Scientist – Liver (Spark Therapeutics)

Staff Fellow – Viral Vaccines (FDA-Center for Biologics Evaluation and Research)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico Comprehensive Cancer Center)

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Scientist – Molecular & Cellular Biology (Deep Genomics, Inc.)

Therapuetic Specialist – Inflammation (Gilead Sciences Inc.)

Team Leader – Cholangiocytes (Miromatrix Medical)

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