Neural Cell News Volume 14.17 | May 06 2020

TOP STORY

ATP and Spontaneous Calcium Oscillations Control Neural Stem Cell Fate Determination in Huntington’s Disease: A Novel Approach for Cell Clock Research

Scientists investigated impacts of calcium channels and purinoceptors on neuronal differentiation of normal mouse embryonic stem cells, with outcomes being compared to those of in vitro models of Huntington’s disease. [Mol Psychiatry] Abstract

(Ranked by impact factor of the journal)

Melatonin Directly Binds and Inhibits Death-Associated Protein Kinase 1 Function in Alzheimer’s Disease

Melatonin significantly decreased death-associated protein kinase 1 expression in a post-transcriptional manner in neuronal cell lines and mouse primary cortical neurons. [J Pineal Res] Abstract

Intracellular Delivery of Parkin Rescues Neurons from Accumulation of Damaged Mitochondria and Pathological α-Synuclein

Cell-permeable Parkin protein recovered damaged mitochondria by promoting mitophagy and mitochondrial biogenesis and suppressed toxic accumulations of α-synuclein in cells and animals. [Sci Adv] Full Article

GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation

The authors showed that Glycerophosphodiester phosphodiesterase 2 (GDE2) signaling underlaid a neuronal pathway that promoted oligodendrocyte maturation through the release of soluble neuronally derived factors. [Cell Rep] Full Article | Graphical Abstract

Srebf1 Controls Midbrain Dopaminergic Neurogenesis

Researchers performed a combined transcriptome and chromatin immunoprecipitation sequencing analysis of midbrain cells after liver X receptor activation, followed by bioinformatic analysis to elucidate the transcriptional networks controlling mDA neurogenesis. [Cell Rep] Full Article | Graphical Abstract

Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

Scientists used RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro neural stem cells and monkey brain sections to model the generation of cortical neuronal fates. [Cell Rep] Full Article | Graphical Abstract

Long Noncoding RNA Mediates Stroke-Induced Neurogenesis

Investigators found that H19 was the most highly upregulated lncRNA in neural stem cells of the subventricular zone of rats subjected to focal cerebral ischemia. [Stem Cells] Abstract

Tet2-Mediated Epigenetic Drive for Astrocyte Differentiation From Embryonic Neural Stem Cells

Researchers discovered that a Ten-eleven translocation (Tet) protein, Tet2, drove astrocyte differentiation from neural stem cells by demethylation of astroglial lineage genes including Gfap. [Cell Death Discov] Full Article

4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells against Oxidative Damage

Using immortalized mouse hippocampal neuronal cells as an in vitro model, 4-hydroxyestrone, an estrone metabolite with little estrogenic activity, was found to have the strongest neuroprotective effect against oxidative neurotoxicity. [Sci Rep] Full Article

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

Investigators identified a role of Anaphase Promoting Complex and its regulatory subunit Cdh1 (Cdh1-APC) as a regulator of protein synthesis in neurons. Proteomic profiling revealed that Cdh1-APC interacted with known regulators of translation, including stress granule proteins. [iScience] Abstract | Graphical Abstract | Full Article

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Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits

The authors propose ways in which combinatorial use of multifunctional recognition molecules enables the complex neuron-neuron interactions that underlie synaptic specificity. [Cell] Full Article | Graphical Abstract

Genetic Predispositions of Parkinson’s Disease Revealed in Patient-Derived Brain Cells

The authors discuss the interplay between genetic predispositions and midbrain neuronal impairments in people living with Parkinson’s disease. [NPJ Parkinsons Dis] Full Article

Visit our reviews page to see a complete list of reviews in the neural cell research field.

DelMar Pharmaceuticals Provides Enrollment Update in Phase II Clinical Trial of VAL-083 for Adjuvant Treatment of Brain Tumors

DelMar Pharmaceuticals, Inc. announced it has enrolled 22 patients in the adjuvant arm of the company’s ongoing Phase II clinical study investigating adjuvant treatment of MGMT-unmethylated glioblastoma multiforme with VAL-083. [DelMar Pharmaceuticals, Inc.] Press Release

Banner Life Sciences Announces Final FDA Approval of BAFIERTAM for Multiple Sclerosis

Banner Life Sciences LLC announced that the FDA granted final approval of BAFIERTAM^™ delayed-release capsules for the treatment of relapsing forms of multiple sclerosis. [Banner Life Sciences LLC] Press Release

‘It Will Not Be Easy.’ as Labs Begin to Reopen, Enormous Challenges Remain

One of the biggest challenges labs face is how to keep their members physically distanced to limit any potential spread of SARS-CoV-2. [ScienceInsider] Editorial

Coronavirus: Share Lessons on Lifting Lockdowns

Countries are starting to lift restrictions on movement, but there is little consensus on how this should be done. Sharing best practice is the way forward. [Nature News] Editorial

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NEW Postdoctoral Associate – Neurobiology Research (Cornell University)

Postdoctoral Position – Neuroscience (Linköping University)

Associate Professor – Molecular Neurobiology (Aarhus University)

Professorship – Molecular Neuropathology (Ludwig-Maximilians-Universität München)

Researcher Position – Transcriptional Activity in Brain Diseases (Italian Institute of Technology)

Postdoctoral Position – Brain and Disease Research (Flanders Institute for Biotechnology)

Postdoctoral Fellow – Neurogenerative Disease (Johns Hopkins University School of Medicine)

Postdoctoral Program – Aging and Alzheimer’s Disease Research (Huntington Medical Research Institutes)

Scientist – Oligonucleotide Therapies for Neurological Disorders (Deep Genomics Inc.)

Postdoctoral Position – Neuroimmunology (LMU University Hospital Munich)

Postdoctoral Position – iPSC Models in Neurodegeneration (Flanders Institute for Biotechnology)

Postdoctoral Fellow – Developmental Neuroscience (Children’s National Hospital)

Postdoctoral Associate – Neuron Diversity Mechanisms in Brain Development (Howard Hughes Medical Institute)

Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research)

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