 | | Vol. 14.39 – 14 October, 2020 |
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| Scientists characterized cell-type-specific cis-regulatory chromatin interactions, open chromatin peaks, and transcriptomes for radial glia, intermediate progenitor cells, excitatory neurons, and interneurons isolated from mid-gestational samples of the human cortex.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers interrogated N6-methyladenosine (m6A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
[Cancer Discovery] |
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| Scientists showed that L19 accumulated in the tumor microenvironment of two orthotopic immunocompetent mouse glioma models.
[Science Translational Medicine] |
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| Investigators employed dopaminergic neurons and microglia differentiated from patient-derived induced pluripotent stem cells carrying LRRK2 G2019S, the most common Parkinson’s disease-associated mutation.
[Nature Communications] |
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| Central in the hippocampal CA3 microcircuit is the mossy fiber (MF) synapse, which provides powerful direct excitatory input and indirect feedforward inhibition to CA3 pyramidal neurons. Researchers dissected its cell-surface protein composition to discover novel regulators of MF synaptic connectivity.
[Nature Communications] |
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| Scientists found that DNA double-strand breaks (DSBs) in oxygen/glucose-deprived neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.
[Science Advances] |
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| Investigators used constellation pharmacology to investigate rat dorsal root ganglion neurons using two models of peripheral nerve injury: chronic constriction injury and spinal nerve ligation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers discovered that mutations of two key lipolysis genes atgl‐1 and lid‐1 led to lipid droplets appearance in neurons of Caenorhabditis elegans. This neuronal lipid accumulation protected neurons from hyperactivation‐triggered neurodegeneration, with a mild decrease in touch sensation.
[EMBO Reports] |
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| Scientists provided experimental evidence that reducing cyclic AMP (cAMP) signaling in a subset of retinal ganglion cells favored the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization.
[Cell Reports] |
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| Investigators showed that nascent blood vessels actively contact dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports] |
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| Researchers discovered that exposure of rat primary neurons to Tat resulted in the up-regulation of an uncharacterized long non-coding RNA (lncRNA), LOC102549805.
[Cell Death & Disease] |
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| Investigators transfected HT22 cells with lentivirus–alpha-synuclein (α-Syn) shRNA, followed by brain-derived neurotrophic factor (BDNF) and manganese stimulation. In vitro experiments indicated that α-Syn selectively interacted with TrkB receptors and inhibited BDNF/TrkB signaling, leading to phosphorylation and downregulation of GluN2B.
[Cell Death & Disease] |
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| The authors review the pathophysiology of Alzheimer’s disease and highlight the sigma ligands that display the capability of preventing or even reversing amyloid-β (Aβ)- and amyloid-β oligomers (AβOs)-induced neurotoxicity and blocking the signal transduction caused by AβOs.
[Neuropharmacology] |
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| Investigators describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment.
[Cellular and Molecular Neurobiology] |
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| Brain Scientific, Inc. submitted a premarket 510(k) application to the United States Food and Drug Administration (FDA) for its next generation NeuroCap™ device. NeuroCap™ is an advanced Electroencephalogram (EEG) electrode array used to obtain rapid EEGs in hospitals, clinics and rural areas where medical resources may be limited.
[Brain Scientific, Inc.] |
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| RELIEF THERAPEUTICS Holding AG and NeuroRx, Inc., announced topline results from 45 patients assessed in an open-label prospective study where 21 patients admitted to an intensive care unit with critical COVID-19 and respiratory failure were treated with RLF-100™ and compared to 24 control patients treated in the same setting.
[NeuroRx, Inc.] |
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| January 9 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | University of Luxembourg- Luxembourg, Luxembourg |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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