 | | Vol. 6.36 – 19 October, 2020 |
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| Scientists describe ways to overcome obstacles in the context of normal human skin, offering a glimpse into the genomic landscapes of individual melanocytes from human skin.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Investigators used Seq-Well S3 (“Second-Strand Synthesis”) to chart the transcriptional landscape of five human inflammatory skin diseases, providing a resource for the further study of human skin inflammation.
[Immunity] |
| | Scientists showed that the poorly characterized herpes simplex virus 1 pUL56 directly binds Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC), stimulating its ubiquitination and proteasomal degradation.
[Cell Reports] |
| | Arp3 depletion in the melanocyte lineage resulted in severe pigmentation defects in dorsal and ventral regions of the mouse skin.
[Development] |
| | Using a human dermal fibroblast cell line in suspension culture, investigators found that high hydrostatic pressure at 50 MPa for ≥ 36 hours completely induced fibroblast cell death via apoptosis based on the morphological changes in transmission electron microscopy, reactive oxygen species elevation, caspase activation and phosphatidylserine membrane translocation.
[Scientific Reports] |
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| Midkine was found to control the transcriptome of melanoma cells, allowing for coordinated activation of nuclear factor-κB and downregulation of interferon-associated pathways.
[Nature Medicine] |
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| The authors used single cell RNA-sequencing of patient tumors to identify three prognostic surface markers (LYPD3, TACSTD2, and LY6D) which correlated with nuclear myocardin-related transcription factor (nMRTF) and resistance to Smoothened inhibitors. The nMRTF cell state resembled transit-amplifying cells of the hair follicle matrix, with AP-1 and TGFß cooperativity driving nMRTF activation.
[Nature Communications] |
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| Researchers report that cancer associated fibroblasts from skin squamous cell carcinomas displayed chromosomal alterations, with heterogeneous NOTCH1 gene amplification and overexpression that also occurred, to a lesser extent, in dermal fibroblasts of unaffected skin.
[Nature Communications] |
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| An increase in heme oxygenase-1 protein was recapitulated in human A375 melanoma cells exposed to fructose in culture.
[Cancer Immunology Research] |
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| The anti-melanoma activity of Nicotinamide, the amide form of Niacin, was assessed in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists presented a multiparameter genome-wide siRNA screening dataset of genes that when depleted, improved the viability and glycolytic response to vemurafenib in BRAFV600 mutated melanoma cells.
[Scientific Data] |
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| In vitro, Oncostatin M promoted invasiveness of keratinocytes and cutaneous squamous cell carcinoma cells and suppressed apoptosis of irradiated keratinocytes.
[Scientific Reports] |
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| The authors present an overview of the mechanisms that result in the transcriptional deregulation of mRNA expression in melanoma cells and assess how these changes facilitate melanoma initiation and progression.
[Oncogene] |
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| Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
[International Journal of Molecular Sciences] |
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| The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for Dupixent®, recommending to extend the approval in the European Union to include children aged 6 to 11 years with severe atopic dermatitis who are candidates for systemic therapy.
[CHMP (Globe Newswire, Inc)] |
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| AbbVie, Inc submitted applications to the US FDA and European Medicines Agency (EMA) seeking approval for RINVOQ™ for the treatment of adults and adolescents with moderate to severe atopic dermatitis.
[AbbVie, Inc] |
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| January 9 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | King’s College London – London, England, United Kingdom |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | University of California, Davis – Sacramento, California, United States |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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