Human Immunology News Volume 8.43 | Nov 3 2020

May 12, 2022

HIN 8.43 | Nov 3 2020

Human Immunology News by STEMCELL Technologies

Vol. 8.43 – 3 November, 2020

TOP STORY

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

Investigators analyzed peripheral-blood exome sequence data independent of clinical phenotype and inheritance pattern to identify deleterious mutations in ubiquitin-related genes.
[New England Journal of Medicine]

Abstract

New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

PUBLICATIONSRanked by the impact factor of the journal

Recurrent
HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]

Abstract

Autofluorescence
Imaging of 3D Tumor-Macrophage Microscale Cultures Resolves Spatial and Temporal Dynamics of Macrophage Metabolism

Scientists demonstrated two-photon autofluorescence imaging of NAD(P)H and FAD to non-destructively resolve spatiotemporal metabolic heterogeneity of individual macrophages within 3D microscale tumor microenvironment models.
[Cancer Research]

Abstract

Molecular
Correlates and Therapeutic Targets in T Cell-Inflamed versus Non-T Cell-Inflamed Tumors across Cancer Types

Investigators correlated the T cell-inflamed gene expression signature with somatic mutations, transcriptional programs, and relevant proteome for different immune phenotypes, by tumor type and across cancers.
[Genome Medicine]

Full Article

Macrophage Immune Memory Controls Endometriosis in Mice and Humans

LPS^low-tolerized human macrophages mitigated the fibro-inflammatory phenotype of endometriotic cells in an interleukin-10-dependent manner.
[Cell Reports]

Full Article Graphical Abstract

Trastuzumab
Upregulates Programmed Death Ligand-1 Expression through Interaction with NK Cells in Gastric Cancer

Programmed death ligand 1 expression was significantly upregulated by trastuzumab in HER2-amplified gastric cancer cell lines co-cultured with peripheral blood mononuclear cells.
[British Journal of Cancer]

Abstract

Toward
a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells

Scientists characterized the phenotype of the peripheral blood circulating cytotoxic cells of 30 healthy donors, in particular the repertoire of cytotoxic markers, using flow cytometry. In parallel, they characterized the antibody-dependent cellular cytotoxicity effector functions of these primary cells by measuring their cytolytic activity against a cancer cell-line expressing HER2 in the presence of trastuzumab and with regards to FCGR3A genotype.
[Frontiers in Immunology]

Full Article

Chronic
Rhinosinusitis and Premorbid Autoimmune Diseases: A Population-Based Case–Control Study

Researchers conducted a population-based case–control study investigating the association between chronic rhinosinusitis and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan.
[Scientific Reports]

Full Article

Circulating CD56⁺ NKG2D⁺
NK Cells and Postoperative Fertility in Ovarian Endometrioma

Investigators demonstrated significant differences in the ratio of CD4/CD8 T cells and the number of CD56⁺ NKG2D⁺ NK cells and γδ T cells between ovarian endometrioma patients and control subjects.
[Scientific Reports]

Full Article

Dielectrophoretic
Characterization of Dendritic Cell Deformability upon Maturation

The authors developed a rapid technique for characterizing the biomechanical properties of dendritic cells using dielectrophoretic forces.
[Biotechniques]

Full Article

Developing
Human Skin Contains Lymphocytes Demonstrating a Memory Signature

Scientists utilized mass and flow cytometry to elucidate early features of human skin immunity. Skin regulatory T cells dynamically accumulate over the second trimester in temporal and regional association with hair follicle development.
[Cell Reports Medicine]

Full Article Graphical Abstract

Virtual Conference Exhibition: Immunology

REVIEWS

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

Immune checkpoint inhibitors have transformed cancer treatment by enabling T cell reactivation; however, response biomarkers are required, as most patients do not benefit.
[Cancer Cell]

Abstract

Antigen
Presentation, Autoantibody Production, and Therapeutic Targets in Autoimmune Liver Disease

Investigators summarize emerging aspects of antigen presentation, autoantibody production, and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases.
[Cellular & Molecular Immunology]

Full Article

INDUSTRY AND POLICY NEWS

FDA
Grants Priority Review and EMA Accepts Regulatory Submission for Pfizer’s Abrocitinib, an Oral Once-Daily JAK1 Inhibitor, for Patients 12 and Up with Moderate to Severe Atopic Dermatitis

Pfizer Inc. announced that the FDA accepted for filing and granted Priority Review designation to the company’s New Drug Application for abrocitini, an investigational oral once-daily Janus kinase 1 inhibitor, for the treatment of moderate to severe atopic dermatitis in patients 12 and older.
[Pfizer Inc. (BusinessWire, Inc.)]

Press Release

Apellis
and Sobi Enter Collaboration for Global Co-development and Ex-US Commercialization of Systemic Pegcetacoplan in Rare Diseases with Urgent Need for New Treatments

Apellis Pharmaceuticals, Inc. and Swedish Orphan Biovitrum AB announced a strategic collaboration to accelerate the advancement of systemic pegcetacoplan, a targeted C3 therapy, for the treatment of multiple rare diseases with high unmet need that impact more than 275,000 patients globally.
[Apellis Pharmaceuticals, Inc.]

Press Release

FEATURED EVENT

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

Recurrent
HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

Autofluorescence
Imaging of 3D Tumor-Macrophage Microscale Cultures Resolves Spatial and Temporal Dynamics of Macrophage Metabolism

Molecular
Correlates and Therapeutic Targets in T Cell-Inflamed versus Non-T Cell-Inflamed Tumors across Cancer Types

Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Trastuzumab
Upregulates Programmed Death Ligand-1 Expression through Interaction with NK Cells in Gastric Cancer

Toward
a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells

Chronic
Rhinosinusitis and Premorbid Autoimmune Diseases: A Population-Based Case–Control Study

Circulating CD56⁺ NKG2D⁺
NK Cells and Postoperative Fertility in Ovarian Endometrioma

Dielectrophoretic
Characterization of Dendritic Cell Deformability upon Maturation

Developing
Human Skin Contains Lymphocytes Demonstrating a Memory Signature

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

Antigen
Presentation, Autoantibody Production, and Therapeutic Targets in Autoimmune Liver Disease

FDA
Grants Priority Review and EMA Accepts Regulatory Submission for Pfizer’s Abrocitinib, an Oral Once-Daily JAK1 Inhibitor, for Patients 12 and Up with Moderate to Severe Atopic Dermatitis

Apellis
and Sobi Enter Collaboration for Global Co-development and Ex-US Commercialization of Systemic Pegcetacoplan in Rare Diseases with Urgent Need for New Treatments

Keystone
Symposia: Single Cell Biology

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Senior
Scientific Researcher – Immunology Discovery

PhD Student – Adoptive T Cell Therapy of Cancer

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

Research
Positions – Cancer and Immunotherapy

Postdoctoral
Associate – Immune Modulatory Therapies

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