 | | Vol. 8.43 – 18 November, 2020 |
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| Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, investigators detected preexisting humoral immunity.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
[Nature Immunology] |
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| Adult COVID-19 cohorts had anti-spike IgG, IgM and IgA antibodies, as well as anti-nucleocapsid IgG antibody, while children with and without multisystem inflammatory syndrome-C had reduced breadth of anti-SARS-CoV-2-specific antibodies.
[Nature Immunology] |
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| Researchers applied single-molecule Fluorescence Resonance Energy Transfer imaging to observe conformational dynamics of S on virus particles.
[Cell Host & Microbe] |
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| Scientists performed RNA structure probing to obtain single-base resolution secondary structure maps of the full SARS-CoV-2 coronavirus genome both in vitro and in living infected cells.
[Nucleic Acids Research] |
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| Investigators demonstrated that ACE2‐Fc could specifically abrogate virus replication by blocking the entry of SARS‐CoV‐2 spike‐expressing pseudotyped virus into both ACE2‐expressing lung cells and lung organoids.
[EMBO Molecular Medicine] |
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| Mass spectrometry was used to identify 526 unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from a panel of healthy donors selected to represent a majority of allele usage from this highly polymorphic molecule.
[Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors used single-cell transcriptomics and CyTOF-based single-cell protein quantification to characterize peripheral immune cells during Ebola virus infection in rhesus monkeys.
[Cell] |
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| Researchers evaluated gene expression profiles in cells from whole blood elicited in naive subjects receiving the hepatitis B surface antigen formulated with different adjuvants.
[Science Translational Medicine] |
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| Scientists investigated the humoral immune correlates of protection from cytomegalovirus (CMV) acquisition in populations of CMV-seronegative adolescent and postpartum women who received the gB/MF59 vaccine.
[Science Translational Medicine] |
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| Investigators identified diverse RNA viruses in N. crassa and other Neurospora species, and showed that N. crassa supported the replication of these viruses as well as some viruses from other fungi.
[Nature Communications] |
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| Scientists report induction of a protective anti-Zika virus (ZIKV) CD8+ T cell response in the HLA-B*0702 Ifnar1−/− transgenic mice using an alphavirus-based replicon RNA vaccine expressing ZIKV nonstructural protein NS3, a potent T cell antigen.
[Science Advances] |
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| Researchers found that expression of the HIV‐1 pathogenesis factor NEF in CD4 T cells undermines their helper function and impairs cognate B‐cell functions including mounting of efficient specific IgG responses.
[EMBO Journal] |
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| Investigators conducted a randomized, observer-blind, comparator-controlled, or quadrivalent recombinant influenza vaccine, safety and immunogenicity trial of quadrivalent nanoparticle influenza vaccine in healthy adults aged ≥65 years.
[Clinical Infectious Diseases] |
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| The authors analyze a selection of existing assays for measuring antibody-mediated virus neutralization and animal models of infection with severe acute respiratory syndrome coronavirus 2 and provide a framework for comparing results between studies and reconciling observed differences in the effects of interventions.
[Nature Reviews Immunology] |
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| Generex Biotechnology Corporation announced that the company has closed a $50 million Licensing and Development Agreement with a consortium of partners in China for the Ii-Key vaccine platform technology from Generex subsidiary NuGenerex Immuno-Oncology.
[Generex Biotechnology Corporation (Globe Newswire, Inc.)] |
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| Emergex Vaccines Holding Limited announced that it has raised $11 million in a funding round supported by new and existing investors.The proceeds of this funding round will enable Emergex to further advance and execute its vaccine development strategy, producing vaccine candidates for some of the world’s most threatening and virulent diseases such as COVID-19, Dengue Fever and pandemic flu.
[Emergex Vaccines Holding Limited (Globe Newswire, Inc.)] |
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| 7 Hills Pharma announced the first healthy volunteers have been dosed in a Phase I trial of 7HP349, the company’s first-in-concept immunostimulant to improve the effectiveness of immunotherapies.
[7 Hills Pharma] |
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| June 10 – June 11, 2021
London, England, United Kingdom |
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| | University of Nantes – Nantes, France |
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| | MRC Laboratory of Molecular Biology – Cambridge, England, United Kingdom |
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| | Queen’s University – Kingston, Ontario, Canada |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Vaud, Switzerland |
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