 | | Vol. 6.45 – 20 November, 2020 |
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| Wildtype and down regulated in adenoma KO mice and crypt-derived colonoids were used as models for intestinal epithelial response. Paracellular permeability was measured using fluorescein Isothiocyanate-dextran flux. Immunoblotting, immunofluorescence, immunohistochemistry and Ribonucleoprotein Immunoprecipitation assays were performed.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that deficiency in Fam3D was associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer.
[Nature Communications] |
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| IL-10/PAK1 double knockout mice were generated and development of colitis and colitis-associated cancer was analyzed. Large intestines were measured and prepared for histology or RNA isolation. Swiss rolls were stained with H&E and PAS. Co-immunoprecipitation and immunofluorescence were performed using intestinal organoids, SW480 and normal human colon epithelial cells.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Using mouse intestinal organoids and human gut‐derived Caco‐2 cells as in vitro models, scientists found that expression of Occludin could be significantly suppressed by ectopic overexpression of Lin 28A.
[FASEB Journal] |
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| High fructose dietH (FrD)‐fed mice were treated orally with mulberroside A for eight weeks. Mulberroside A was found to inhibit hippocampal neuroinflammation and neurogenesis reduction in HFrD‐fed mice.
[Journal of Neurochemistry] |
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| The authors investigated the role of toll-like receptor 4 (TLR4) in intestinal fibrosis using not only a murine fibrosis model but also human myofibroblasts and intestinal epithelial cells. Colon fibrosis was induced in TLR4-deficient mice and its wild-type counterparts with 3% dextran sulfate sodium.
[Scientific Reports] |
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| Myeloid hypoxia inducible factors(HIF)-1α and HIF-2α played opposing roles in acute dextran sodium sulfate colitis. Thus, not only a cell type specific, but also the isoform specific modulation of HIFs need to be addressed in attempts to modify HIF for therapeutic purposes.
[International Journal of Molecular Sciences] |
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| Scientists implicated Musashi1 in mouse postnatal development of multiple organs, with Notch signaling alterations contributing to intestinal defects.
[Molecular Biology of the Cell] |
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| Investigators demonstrated that aryl hydrocarbon receptor (AhR) activation by LP-5 could inhibit the Src kinase to increase tight junction protein levels and down-regulate the expression of inflammatory cytokines to protect the intestinal barrier and finally alleviate dextran sulfate sodium-induced colitis.
[Journal of Agricultural and Food Chemistry] |
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| Scientists discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development.
[Cell Death & Differentiation] |
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| BiomX Inc. announced that phages identified by BiomX with a broad host range were able to target and eradicate 89 percent of distinct gut-harbored Klebsiella pneumoniae strains isolated from samples obtained from patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC).
[Biom X Inc.] |
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| March 17 – March 19, 2021
Virtual |
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| | Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | The University of Utah – Salt Lake City, UT, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Moffitt Cancer Center – Tempa, Florida, United States |
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