 | | Vol. 12.49 – 17 December, 2020 |
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| Investigators report an inverse correlation between glutamine metabolic genes and markers of T cell-mediated cytotoxicity in human basal-like breast cancer patient datasets, with increased glutamine metabolism and decreased T cell cytotoxicity associated with poor survival.
[Journal of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that BCL2 and BCL(X)L increased the metabolic robustness of MCF7 cells and that this was associated with increased mitochondrial NAD(P)H and ATP levels.
[Cell Death & Differentiation] |
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| Researchers demonstrated that regulatory T cell ablation-dependent anti-tumor effects in murine breast cancer required intratumoral recruitment of CCR2+ inflammatory monocytes, which primarily differentiated into tumor-associated macrophages, and led to reprogramming of their function in an IFN-γ-dependent manner.
[Cell Reports] |
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| Loss and gain of function studies revealed that FZD5 contributed to TNBC cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling.
[Cell Death & Disease] |
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| Through lipidomics and biochemical approaches, scientists demonstrated that photodynamic therapy efficiency and specificity relied on polyunsaturated fatty acid-enriched membranes and on the better capacity to deal with photo-oxidative damage displayed by non-tumorigenic cells.
[Cell Death & Disease] |
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| The authors provided evidence that nandrolone inhibited breast cancer cell proliferation and migration by antagonizing the PI3K/Akt/NF-κB signaling pathway, which eventually resulted in RACK1 downregulation.
[Oncogenesis] |
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| Scientists investigated the metabolomic changes in triple negative and luminal subtype breast cancer cell lines in response to acidosis and lactic acidosis.
[Scientific Reports] |
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| Researchers evaluated the fundamental effects of environmental acidification on mammary carcinoma cells in standard 2D cultures and 3D spheroids.
[Scientific Reports] |
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| The authors identified the roles of YY1-mediated long non-coding RNA Kcnq1ot1 in TNBC. The paired samples of tumor tissues and adjacent tissues were collected to determine YY1, lncRNA Kcnq1ot1, and PTEN expression using RT-qPCR and Western blot analysis followed by analysis of the relationship between them and patient survival.
[Cancer Gene Therapy] |
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| Investigators describe recent efforts in developing small interfering RNA (siRNA) therapeutics for the treatment of breast cancer, with particular emphasis on tumor microenvironment (TME) regulation. They focus on studies that adapt siRNA design to reprogram/re-educate the TME and eradicate the interplay between cancer cells and TME.
[Cancers] |
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| The authors review the biological characteristics of long non‐coding RNAs (lncRNAs), and present the current state of knowledge concerning the expression, function and regulation of lncRNAs in TNBC.
[Cell Proliferation] |
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| Zai Lab Limited announced that the FDA has approved MARGENZA™, in combination with chemotherapy, for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease.
[Zai Lab Limited] |
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| Seagen Inc. announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion recommending the approval of TUKYSA® in combination with trastuzumab and capecitabine for the treatment of adult patients with HER2-positive locally advanced or metastatic breast cancer who have received at least two prior anti-HER2 treatment regimens.
[Seagen Inc.] |
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| January 7 – 8, 2021
Virtual |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | University of Iowa Carver College of Medicine – Iowa City, Iowa, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | King’s College London – London, England, United Kingdom |
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