| Vol. 7.02 – 22 January, 2021 |
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| CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation. [Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the role of nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) in intestinal inflammation. Human intestinal epithelial cells expressed NTPDase8 and P2Y6 similarly as in mice. [Gut] |
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| Researchers studied the cytotoxic, proinflammatory, and DNA damaging properties of polyvinylpyrrolidone‐capped silver and titanium dioxide engineered nanomaterials in four in vitro models of increasing complexity—from proliferating Caco‐2 and HT29‐MTX‐E12 monocultures to long‐term transwell triple cultures including THP‐1 macrophages to reproduce the human intestine in healthy versus inflamed‐like state. [Small] |
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| The authors showed that HAND1 was expressed in aggressive gastrointestinal stromal tumor, modulating KIT and core transcription factor expression and supporting proliferative cellular programs. [Clinical Cancer Research] |
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| Using a high-throughput approach that combined enteroid monolayers and quantitative imaging, scientists identified conditions that enriched for specific cell types as well as interactions between pathways. [Developmental Cell] |
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| Utilizing a mouse model in which MUC2 was fluorescently tagged, thereby allowing visualization of single goblet cells (GCs) in intact colonic crypts, the authors showed that murine colonic GCs had functional LRRC26-associated BK channels. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists explored the mechanism regarding AMP-activated protein kinase-mediated β-catenin degradation in chemotherapy resistance in colon cancer. β-catenin was upregulated in colon cancer tissues and cells, as it was positively correlated with the malignancy and poor prognosis, and chemotherapy resistance of colon cancer. [Molecular Therapy-Nucleic Acids] |
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| Researchers investigated the intracellular mechanism of glucagon-like peptide-1 (GLP-1) synthesis in L cells from the perspective of miRNA. They found that GLP-1 level was down-regulated in the plasma and ileum tissues of obese mice, while the ileac miR-194 expression was up-regulated. [Cell Death & Disease] |
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| Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation. [Cell Death & Disease] |
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| The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured. [Cancer Gene Therapy] |
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| Investigators examined whether vinblastine could remove residual undifferentiated human induced pluripotent stem cells in human induced pluripotent stem cells-derived intestinal epithelial cells (hiPSC-IECs), and attempted to generate hiPSC-IECs applicable to transplantation medicine. [Molecular Therapy-Methods & Clinical Development] |
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| Researchers report YTHDF1 was significantly upregulated in human colon tumors and cell lines. Overexpression of YTHDF1 decreased the cisplatin sensitivity of colon cancer cells. [Molecular Therapy-Oncolytics] |
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| Scientists assessed the current literature detailing the effects of ω-3 polyunsaturated fatty acids (PUFAs) on epithelial cells. Marine-derived ω-3 PUFAs, eicosapentanoic acid and docosahexanoic acid, as well as plant-derived alpha-linolenic acid, are incorporated into intestinal epithelial cell membranes, prevent changes to epithelial permeability, inhibit the production of pro-inflammatory cytokines and eicosanoids and induce the production of anti-inflammatory eicosanoids and docosanoids. [Foods] |
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| Bristol Myers Squibb announced that the FDA has accepted its supplemental Biologics License Application for Opdivo®, in combination with fluoropyrimidine- and platinum-containing chemotherapy, for the treatment of patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma, based on results from the CheckMate-649 trial. [Bristol Myers Squibb] |
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| University of Freiburg – Freiburg, Germany |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| Medical University of Gdańsk – Gdańsk, Poland |
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| Karolinska Institutet – Huddinge, Sweden |
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| Aichi Cancer Center – Nagoya, Japan |
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| Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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