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| Researchers developed yeast-based engineered probiotics that expressed a human P2Y2 purinergic receptor with up to a 1,000-fold increase in extracellular adenosine triphosphate sensitivity. These self-tunable yeast probiotics suppressed intestinal inflammation in mouse models of inflammatory bowel disease, reducing intestinal fibrosis and dysbiosis.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a Drosophila intestinal model, scientists found that tumor cells outcompeted nearby enterocytes by influencing cell adhesion and contractility.
[Developmental Cell] |
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| The authors revealed that neonatal susceptibility to group B streptococcus (GBS) meningitis resulted from the age-dependent immaturity of the intestinal microbiota and developmental pathways associated with neonatal tissue growth, which both concurred to GBS gut colonization, systemic dissemination, and neuroinvasion.
[Cell Reports] |
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| VBIT-12 treatment of cultured colon cells inhibited the DSS-induced voltage-dependent-anion channel 1 (VDAC1) overexpression, oligomerization, and apoptosis.
[Molecular Therapy] |
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| In colorectal cancer cells lacking PD-L1, treatment with JNK-IN-8, an MCL-1 antagonist, or their combination promoted apoptosis and reduced long-term clonogenic survival by anticancer drugs.
[Oncogene] |
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| The authors detected the expression levels of SLC2A5 in colorectal cancer (CRC) tissues and CRC cell lines by western blotting, qRT-PCR and immunohistochemistry. CRC cell lines with stable overexpression or knockdown of SLC2A5 were constructed to evaluate the functional roles of SLC2A5 in vitro through conventional assays.
[British Journal of Cancer] |
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| Fenofibrate reduced IEL density in the duodenum of dogs with diabetes mellitus and enhanced markers of intestinal barrier function in vivo and in vitro.
[Scientific Reports] |
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| Investigators found that rotavirus infection neither induced significant long-lasting microbiota community changes in the small or large intestine nor affected the severity of subsequent dextran sulfate sodium-induced colitis.
[Scientific Reports] |
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| Scientists characterized cetuximab and panitumumab exposure influence on miR expression in colorectal cancer cells to identify those regulating the EGFR pathway and implicated in resistance to treatment.
[Biomarkers in Medicine] |
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| Investigators review the current state of the role of these cytokines in hepatology and gastroenterology and discuss the progress achieved in translating therapeutics targeting gp130 signaling into clinical practice.
[Nature Reviews Gastroenterology & Hepatology] |
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| Data on the use of immunosuppressive and biologic therapies for gastrointestinal diseases is discussed with a primary focus on inflammatory bowel disease, autoimmune hepatitis and liver transplantation.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors outline the critical areas and challenges that must be addressed when transitioning laboratory-based discovery of intestinal organoids, through an investigational new drug application to first-in-human clinical trial, and encourage investigators to consider the required regulatory steps from the earliest stage of the translational process.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Synthetic Biologics, Inc., a clinical-stage company leveraging the microbiome to develop therapeutics designed to prevent and treat gastrointestinal diseases, announced that patient dosing and observation has been completed in its Phase I clinical trial of SYN-020 intestinal alkaline phosphatase.
[Synthetic Biologics, Inc.] |
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| Bristol Myers Squibb announced that the European Commission has approved Opdivo plus Yervoy for the treatment of adult patients with mismatch repair deficient or microsatellite instability-high metastatic colorectal cancer after prior fluoropyrimidine-based combination chemotherapy.
[Bristol Myers Squibb] |
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| October 28 – 29, 2021
Virtual |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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| | City of Hope – Monrovia, California, United States |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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