 | | Vol. 15.28 – 21 July, 2021 |
| | | Researchers generated an in vitro model for developmental and epileptic encephalopathies, using the devastating WW domain-containing oxidoreductase-related epileptic encephalopathy syndrome as a prototype, by establishing brain organoids from CRISPR-engineered human ES cells and from patient-derived induced pluripotent stem cells.
[EMBO Molecular Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Trophoblast glycoprotein-targeted cell sorting enriched FOXA2+LMX1A+ vmDA precursors and helped attain efficient behavioral recovery of rodent Parkinson’s disease models with increased numbers of TH+, NURR1+, and PITX3+ vmDA neurons in the grafts.
[npj Parkinson’s Disease] |
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| Pharmacological blockage of NF-κB nuclear translocation by SN-50 prevented microglial activation and alleviated the damage of dopaminergic neurons induced by microglial DJ-1 deficiency in vivo and in vitro.
[Cell Death & Disease] |
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| Scientists found that during late in vitro neurogenesis induced pluripotent stem cells-derived cortical neurons of the control group exhibited membrane properties compatible with “mature” neurons.
[Cell Death & Disease] |
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| The authors investigated the exact mechanisms underlying KCa1.1-mediated neuroexcitation of myelinated Ah-type baroreceptor neurons in the presence or absence of estrogen.
[Acta Pharmacologica Sinica] |
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| The role of oligodendrocyte lineage cells, the largest glial population in the adult central nervous system, in the pathogenesis of Alzheimer’s disease remains elusive. Researchers developed a culture method for adult oligodendrocyte progenitor cells.
[Communications Biology] |
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| Scientists demonstrated that tunneling nanotubes structures were induced between glioblastoma cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria.
[Scientific Reports] |
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| The authors developed a method to non-invasively detect synaptic relationships among neurons from in vitro networks.
[Scientific Reports] |
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| Scientists used induced pluripotent stem cells from patients with hereditary sensory neuropathy type 1 to determine whether endogenous 1-deoxysphingolipid bases were neurotoxic, patho-mechanisms of toxicity and response to therapy.
[Cell Reports Medicine] |
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| Investigators extensively review the experimental findings of the direct conversion of glial cells to neurons in vitro and in vivo and discuss the remaining issues and challenges related to the glial subtypes and the specificity and efficiency of direct cell-reprograming, as well as the influence of the microenvironment.
[Neuroscience Bulletin] |
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| The authors cast a new, medically oriented light on hypothalamic neuroanatomy and contribute to a better understanding of the mechanisms responsible for neuropeptide-related physiology and the nature of possible neuroendocrinal interactions between local regulatory pathways.
[Journal of Chemical Neuroanatomy] |
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| Wake Network, Inc. is pleased to announce a collaboration with the Lieber Institute for Brain Development to develop a one-of-a-kind, genetics-based approach to psychedelic integration and clinical research on traumatic brain injury.
[Wake Network, Inc.] |
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| Abhishek Shrivastava, assistant professor in the School of Life Sciences and the Biodesign Institute, and his collaborator, David J. Durgan, assistant professor of anesthesiology and cellular and molecular physiology at the Baylor College of Medicine, were selected as one of six multidisciplinary teams to receive the 2021 Scialog Collaborative Innovation Award for their project that looks at how bacterial outer membrane vesicles act as modulators of microbiota-brain communication involved in the development of neurological diseases.
[Arizona State University] |
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| August 23 – 25, 2021
Virtual |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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