 | | Vol. 7.33 – 20 September, 2021 |
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| Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Investigators established a robust, high-throughput cochlear organoid platform that facilitates 3D expansion of cochlear progenitor cells and differentiation of hair cells in a temporally regulated manner.
[Stem Cell Reports] |
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| Researchers reported that the ROCK signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.
[Molecular Carcinogenesis] |
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| The authors found that lncRNA BASP1-AS1 was essential for the development and prognosis of melanoma. The ectopic expression of BASP1-AS1 promoted cell proliferation, migration, and invasion in both A375 and SK-MEL-2 cells.
[Cancer Cell] |
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| Stimulator of IFN genes (STING) is a universal receptor that recognizes cytosolic DNA and triggers innate immune activation. Investigators elucidated the role of STING in the inflammation during psoriasis.
[Journal of Investigative Dermatology] |
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| Scientists investigated the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation on patients.
[Scientific Reports] |
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| Researchers showed that paired-like homeodomain transcription factor 1 (PITX1) plays a crucial role in the inhibition of melanoma progression through regulation of SRY-box transcription factors (SOX) gene family mRNA transcription.
[Scientific Reports] |
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| The authors evaluated the role of the lncRNA TINCR ubiquitin domain containing TINCR in cutaneous malignant melanoma in vitro and in vivo.
[Oncology Reports] |
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| Researchers investigated the effects of polybrominated diphenyl ethers used as flame retardants on phenotypic features of melanoma cells that are important for cancer.
[Environmental Science and Pollution Research] |
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| Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.
[Tissue Engineering Part C-Methods] |
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| The authors illustrate the effect of feeding time on the skin circadian clock and skin function, a previously overlooked area of research. They discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing.
[Febs Letters] |
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| Bristol Myers Squibb announced that the US FDA has accepted for priority review the Biologics License Application for the LAG-3-blocking antibody relatlimab and nivolumab fixed-dose combination, administered as a single infusion, for the treatment of adult and pediatric patients with unresectable or metastatic melanoma.
[Bristol Myers Squibb] |
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| October 19 – 20, 2021
Virtual |
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| University of Minnesota – Austin, Minnesota, United States |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| University of Colorado – Aurora, Colorado, United States |
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| University of California Irvine – Irvine, California, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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