Human Immunology News Volume 9.37 | Sep 21 2021

May 12, 2022

2021-09-21 | HIN 9.37

Human Immunology News by STEMCELL Technologies

Vol. 9.37 – 21 September, 2021

TOP STORY

Conventional Type I Dendric Cells Maintain a Reservoir of Proliferative Tumor-Antigen Specific TCF-1⁺ CD8⁺ T Cells in Tumor-Draining Lymph Nodes

In tumors, a subset of CD8⁺ T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. Scientists examined the mechanisms that maintained these cells in an autochthonous model of lung adenocarcinoma.
[Immunity]

Abstract Graphical Abstract

Attend the Keystone Symposia: Maternal-Fetal Newborn Immunity!

PUBLICATIONSRanked by the impact factor of the journal

Gut Microbiota-Mediated Secondary Bile Acids Regulate Dendritic Cells to Attenuate Autoimmune Uveitis through TGR5 Signaling

Restoration of the gut bile acids pool attenuated severity of experimental autoimmune uveitis in association with inhibition of nuclear factor κB related pro-inflammatory cytokines in dendritic cells.
[Cell Reports]

Full Article Graphical Abstract

Chimeric Antigen Receptor T Cells Self-Neutralizing IL6 Storm in Patients with Hematologic Malignancy

Researchers presented a clinical investigation of anti-CD19 and anti-BCMA CART secreting an anti-IL6 scFv and IL1 receptor antagonist in treating patients with hematologic malignancy.
[Cell Discovery]

Full Article

A Randomized Phase II Trial of Idiotype Vaccination and Adoptive Autologous T Cell Transfer in Multiple Myeloma Patients

In this randomized, Phase II trial, eligible patients received either the control or idiotype-keyhole limpet hemocyanin vaccine, an auto-transplant, vaccine-specific co-stimulated T cells expanded ex vivo, and two booster doses of the assigned vaccine.
[Blood]

Abstract

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.
[Frontiers in Immunology]

Full Article

Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8⁺ T Cell Proliferation

Analysis of fresh tumor samples from clear cell renal cell carcinoma patients unraveled the presence of a high frequency of tumor-infiltrating PD-L1⁺ natural killer (NK cells), suggesting that these NK cells might exhibit immunoregulatory functions.
[Frontiers in Immunology]

Full Article

The Immunotherapy Candidate TNFSF4 May Help the Induction of a Promising Immunological Response in Breast Carcinomas

Investigators identified the oncogenic features of TNFSF4 in breast carcinoma. TNFSF4 was revealed to be closely related to treatment that induced antitumor immunity and to interact with multiple immune effector molecules and T cell signatures
[Scientific Reports]

Full Article

B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-donor CD4+ T Cell Responses in Highly Sensitized Transplant Recipients

Scientists investigated the impact of pretransplant desensitization with rituximab on anti-donor T cell responses in donor-specific anti-human leukocyte antigen antibody-positive transplant recipients.
[Scientific Reports]

Full Article

Systematic Discovery and Validation of T Cell Targets Directed against Oncogenic KRAS Mutations

Researchers evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.
[Cell Reports Methods]

Full Article Graphical Abstract

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REVIEWS

Innate Immune Detection of Lipid Oxidation as a Threat Assessment Strategy

The authors highlight emerging functions of oxidized phosphocholines in dendritic cells and macrophages that drive unique inflammasome and migratory activities and hypermetabolic states.
[Nature Reviews Immunology]

Full Article

INDUSTRY AND POLICY NEWS

First Patients Given Novel Cell Therapy in Leukemia Trial

GammaDelta Therapeutics announced that it has initiated a First-in-Human Phase I clinical trial in the US, evaluating a unique gamma-delta T cell therapy for the treatment of acute myeloid leukemia.
[The Francis Crick Institute]

Press Release

T-Cure Bioscience Announces US FDA Clearance of Investigator-Initiated Clinical Trial for KK-LC-1 TCR-T against Multiple Solid Tumors

T–Cure Bioscience, Inc. announced that the US FDA has approved the Investigational New Drug application to initiate a Phase I clinical study evaluating a T cell receptor (TCR)–based product candidate for the treatment of tumors expressing Kita–Kyushu lung cancer antigen 1 (KK-LC-1), such as gastric, cervical, lung, breast cancers and other KK–LC–1 positive epithelial cancers.
[T–Cure Bioscience, Inc.]

Press Release

FEATURED EVENT

Conventional Type I Dendric Cells Maintain a Reservoir of Proliferative Tumor-Antigen Specific TCF-1⁺ CD8⁺ T Cells in Tumor-Draining Lymph Nodes

Gut Microbiota-Mediated Secondary Bile Acids Regulate Dendritic Cells to Attenuate Autoimmune Uveitis through TGR5 Signaling

Chimeric Antigen Receptor T Cells Self-Neutralizing IL6 Storm in Patients with Hematologic Malignancy

A Randomized Phase II Trial of Idiotype Vaccination and Adoptive Autologous T Cell Transfer in Multiple Myeloma Patients

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8⁺ T Cell Proliferation

The Immunotherapy Candidate TNFSF4 May Help the Induction of a Promising Immunological Response in Breast Carcinomas

B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-donor CD4+ T Cell Responses in Highly Sensitized Transplant Recipients

Systematic Discovery and Validation of T Cell Targets Directed against Oncogenic KRAS Mutations

Innate Immune Detection of Lipid Oxidation as a Threat Assessment Strategy

First Patients Given Novel Cell Therapy in Leukemia Trial

T-Cure Bioscience Announces US FDA Clearance of Investigator-Initiated Clinical Trial for KK-LC-1 TCR-T against Multiple Solid Tumors

Scandinavian Society for Immunology 50th Anniversary Meeting (SSI)

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PhD Scientists – Tumor Immune Microenvironment

Postdoctoral Associate – Mucosal Immunology

Postdoctoral Position – Cancer Biology

Assistant Professor – Tumor Immunology and Experimental Immunotherapy

Postdoctoral Fellowship – Innate Immune Regulation

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