 | | Vol. 16.40 – 13 October, 2021 |
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| ESCs expressing a chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed transcriptomic analysis on wild-type and Importin-13-knockout mouse ESCs, revealing enrichment of differentially expressed genes involved in stress responses and apoptosis regulation.
[Nature Communications] |
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| The authors profiled H3K27me3 and H3K4me3 levels along with gene expression in mouse ESCs with localized Wnt3a signaling, revealing the cell type-specific maps of the epigenome and transcriptome in divided daughter cells.
[Nature Communications] |
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| Using newly derived rabbit PSCs, investigators showed robust and rapid induction of rabbit primordial germ cell (rbPGC)-like cells in vitro with WNT and BMP morphogens, which revealed SOX17 as the critical regulator of rbPGC fate as in several non-rodent mammals.
[Cell Reports] |
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| Researchers employed non-homologous recombination and generated a mouse ESC line carrying a transgene expressing DNMT1Y495C mutation in the wild-type background as a model for studying the abnormal neurogenesis due to this mutation.
[Stem Cell Research] |
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| To further understand the exact role of FLNC in dilated cardiomyopathy, scientists generated a human FLNC knockout cell line from the original ESC line H9 by CRISPR/Cas9 gene editing technology.
[Stem Cell Research] |
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| To better understand the role of TAF8 in TFIID, the authors investigated the requirement of the different regions of TAF8 for the in vitro assembly of lobe B and C, and the importance of certain TAF8 regions for mouse ESC viability.
[Journal of Biological Chemistry] |
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| Researchers showed that mouse ESCs that lacked or overexpressed haspin, albeit prone to chromosome misalignment during metaphase, could still divide, expand and differentiate.
[Scientific Reports] |
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| Activation of activin A signaling stimulated NANOG expression during self-renewal of bovine ESCs but suppressed cells expressing pluripotency markers in the blastocyst and increased cells expressing CDX2.
[Biology Open] |
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| Scientists outline the particular approaches in the different published clinical trials for cell-based therapies for retinal diseases, and present the controversies surrounding experimental treatments offered outside of legitimate studies.
[Stem Cell Research & Therapy] |
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| The authors discuss disease modeling and the therapeutic strategies being explored with iPSC technologies for the two most common inherited optic neuropathies, namely, dominant optic atrophy and Leber hereditary optic neuropathy.
[Journal of Neuro-Ophthalmology] |
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| The Hereditary Neuropathy Foundation (HNF), in partnership with Rarebase, is leading the charge in the first-ever research initiative to tackle multiple types of CMT in one project, with a primary goal to test candidate drugs in patient-derived cellular models, specifically; iPSC-derived neurons.
[The Hereditary Neuropathy Foundation] |
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| Century Therapeutics, Inc., a biotechnology company developing iPSC-derived cell therapies in immuno-oncology, and Outpace Bio, announced a research collaboration in CAR engineering.
[Century Therapeutics, Inc.] |
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| November 6 – 7, 2021
Waterville Valley, New Hampshire, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | University of Helsinki – Helsinki, Finland |
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