 | | Vol. 6.37 – 1 November, 2021 |
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| Researchers identified endothelial cell autophagy as a negative regulator of neutrophil diapedesis in acute physiological inflammation.
[Autophagy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that lymphoma caused severe high endothelial venules (HEVs) regression in mouse models that phenocopied aggressive human B cell lymphomas, and that HEV dedifferentiation occurred as a consequence of a disrupted lymph-carrying conduit system.
[Cell Reports] |
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| The authors determined the novel role for a disintegrin and metalloproteinase 17 in impaired wall shear stress mechanosensing, which was hypothesized to contribute to aging-associated abnormal vascular remodeling.
[GeroScience] |
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| Researchers showed that primary human endothelial cells expressed very low levels of the SARS-CoV-2 receptor ACE2 and the protease TMPRSS2, which blocked their capacity for productive viral infection, and limited their capacity to produce infectious virus.
[Clinical & Translational Immunology] |
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| The effects of conditioned media from oral squamous cell carcinoma cells on the angiogenic activities of endothelial cells were analyzed using a tube formation assay.
[Cancer Cell International] |
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| Investigators suggested that miR548ai, a rarely known microRNA, may have provided a molecular target for protection against smooth muscle cell/exosome-induced endothelial cell dysfunction.
[Cell Death Discovery] |
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| An intracerebral hemorrhage (ICH) model was established by injecting autologous blood into the right basal ganglia of Sprague-Dawley rats. After ICH induction, the protein levels of Krüppel-like transcription factor 2 were reduced.
[Brain Research Bulletin] |
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| Scientists prepared and identified endothelial progenitor cells (EPCs), and the biological functions and molecular characteristics were compared between EPCs from DB/+ and DB/DB mice.
[Journal of Diabetes Research] |
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| Researchers described an effective method of isolating a human placenta substrate that induced the spontaneous formation of an interconnected network of green fluorescence labeled HUVECs in vitro.
[Tissue Engineering Part C-Methods] |
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| The authors describe the current knowledge of the effects of aging on the immune system and the cerebral vasculature and how these changes alter the immune response to stroke and vascular dementia in animal and human studies.
[Molecular Psychiatry] |
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| Scientists propose a model of care incorporating VEGF inhibitors (VEGFi) into the treatment of epithelial ovarian cancer, highlighting the need to change from the prescription of single courses of VEGFi, to allow use and re-use as clinically indicated.
[British Journal of Cancer] |
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| SomaLogic announced a strategic collaboration with University Hospitals Cleveland Medical Center, where they will evaluate the impact of the company’s SomaSignal™ tests on the medical management of diabetic patients who are at a higher risk of cardiovascular disease.
[SomaLogic] |
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| Purple Biotech Ltd. announced the expansion of an existing research agreement will evaluate the potential efficacy of the combination of NT219, a dual inhibitor, novel small molecule that simultaneously targets IRS1/2 and STAT3, and immuno-oncology drugs, such as anti-CTLA4 or anti-PD1/PDL1 antibodies.
[Purple Biotech Ltd.] |
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| December 1 – 10, 2021
Virtual |
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| | Columbia University – New York, New York, United States |
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| | Radboud University Medical Center – Nijmegen, The Netherlands |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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