 | | Vol. 6.42 – 6 December, 2021 |
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| Researchers reported that bone marrow (BM) vascular endothelial cells secreted semaphorin 3 A (SEMA3A) in response to myeloablation and SEMA3A induced p53 – mediated apoptosis in BM endothelial cells via signaling through its receptor, Neuropilin 1, and activation of cyclin dependent kinase 5.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| SHP2 inefficiency impaired endothelial cell proliferation, migration, and tubulogenesis through downregulating the expression of proangiogenic SRY-Box transcription factor 7, whose re-expression restored endothelial function in SHP2-knockdown cells.
[Nature Communications] |
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| Scientists used an integrated in vitro and in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide enhanced blood-brain barrier integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1.
[Microbiome] |
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| The authors designed a non-human leukocyte antigen (HLA) antibody detection immunoassay using HLA class I and II–deficient glomerular endothelial cells that had been previously generated through CRISPR/Cas9-induced B2M and CIITA gene disruption.
[Journal of the American Society of Nephrology] |
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| NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.
[Cardiovascular Research] |
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| Scientists showed that PM exposure significantly inhibited various beneficial functions of endometrial stem cells, such as their self-renewal, transdifferentiation, and migratory capacities, in vitro and in vivo through the PM target gene SERPINB2, which has recently been shown to be involved in multiple stem cell functions.
[Experimental and Molecular Medicine] |
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| Researchers identified lncRNAs that were dysregulated in human induced pluripotent stem cell-derived endothelial cells following 24 hours of electronic-cigarette aerosol extract treatment via microarray analysis.
[Stem Cell Research & Therapy] |
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| Investigators assessed the effects of sodium-glucose co-transporter type 2 inhibitors empagliflozin and dapagliflozin on human aortic endothelial cells and underlying vasculo-protective mechanisms in an in vitro model of ponatinib-induced endothelial toxicity.
[Vascular Pharmacology] |
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| The authors evaluated the potential of a gelatine-hyaluronic acid hydrogel loaded with the angiogenic growth factor, VEGF, as a local delivery system to aid in maintaining vascularization in a bisphosphonate-treated rodent maxillary extraction defect.
[Scientific Reports] |
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| Investigators tested the hypothesis that the cystic fibrosis transmembrane conductance regulator regulated endothelial actin cytoskeleton dynamics and cellular alignment in response to flow.
[physiological reports] |
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| Scientists present recent studies that support an important role for endothelial cells as central mediators of many of the physiological and pathological functions of the adipose tissue and highlight several unknown aspects of adipose tissue vascular biology.
[Obesity Reviews] |
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| The authors review interactions between adenoviral vectors and the hemostatic systems that are of possible relevance in vaccine-associated thrombotic thrombocytopenia syndrome.
[Haematologica] |
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| Investigators summarize regulatory factors and signaling mechanisms of regulatory death in endothelial cells, discussing their effects in the context of the atherosclerotic procession.
[Archives of Biochemistry and Biophysics] |
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| Isarna Therapeutics announced the enrollment of the first patient in the BETTER Study, a parallel, two-segment Phase IIa clinical study to evaluate Isarna’s lead candidate ISTH0036 in patients with wet age-related macular degeneration (AMD) and diabetic macular edema (DME).
[Isarna Therapeutics] |
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| February 5 – 9, 2022
Maui, Hawaii, United States |
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| | University of Mississippi Medical Center – Jackson, Mississippi, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | Accession Therapeutics – Oxford, England, United Kingdom |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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