| Vol. 14.21 – 2 June, 2022 |
| |
|
|
| Investigators showed that breast cancer-derived extracellular vesicles suppressed pancreatic insulin secretion to impair glucose homeostasis. [Nature Cell Biology] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Using a syngeneic genetically-engineered mouse model of breast tumor driven by Brca1 deficiency, researchers showed that tumor-associated macrophages blunted PARP inhibitors efficacy both in vivo and in vitro. [Nature Communications] |
|
|
|
| Scientists uncovered the role of Hippo signaling and the tumor suppressor function of YAP in estrogen receptor positive (ER+) breast cancer. [Nature Communications] |
|
|
|
| The authors investigated the role of AMP-activated protein kinase in the maintenance of breast cancer stem cells state/function. [Disease Models & Mechanisms] |
|
|
|
| Investigators used advanced breast cancers (ABCs)-derived organoids as the ex vivo therapeutic platform to clarify the effectiveness of resveratrol against different ABC subtypes. [Phytotherapy Research] |
|
|
|
| Scientists investigated the biological function of COL8A1 on TNBC progression. The tumor growth and metastasis of TNBC cells were evaluated using three-dimensional culture methods and xenograft mouse models [Breast Cancer Research and Treatment] |
|
|
|
| Conditioned media-based experiments showed that young adipose-derived stromal/stem cells donor age elevated endocrine response in ER-α+ breast cancer cell lines. [Stem Cells and Development] |
|
|
|
| Researchers investigated the oncolytic activity of live-attenuated poliovirus in breast cancer cell lines. The CD155 expression level in two human breast cancer cell lines and a normal breast cell line were evaluated using real-time PCR and flow cytometry. [Breast Cancer] |
|
|
|
| The authors investigated the effects and underlying mechanism of REC8 on the proliferation, migration and invasion of breast cancer cells. [Molecular Medicine Reports] |
|
|
|
|
| Investigators note the deregulation of several Hippo signaling elements in breast cancer patients. Moreover, they see examples of negative correlations between methylation of Hippo genes and mRNA expression. [Biomedicine & Pharmacotherapy] |
|
|
|
|
| SynDevRx, Inc. announced the opening of a first-of-its-kind Phase Ib/II study for patients with TNBC and baseline insulin resistance, testing the novel study drug evexomostat in combination with standard-of-care treatment Halaven®. [SynDevRx, Inc. (Business Wire, Inc.)] |
|
|
|
|
| November 16 – 18, 2022 Melbourne, Victoria, Australia |
|
|
|
|
|
| Institute of Cancer Research – London, England, United Kingdom |
|
|
|
| Institute of Cancer Research – London, England, United Kingdom |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| Oslo University Hospital – Oslo, Norway |
|
|
|
|
|