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Endometrial Cancer PDX-Derived Organoids (PDXOs) and PDXs with FGFR2c Isoform Expression Are Sensitive to FGFR Inhibition

[npj Precision Oncology] Researchers reported the establishment of 16 endometrial cancer (EC) PDXOs with or without FGFR2c expression. In vitro treatment of five EC PDXOs with BGJ398 showed significant cell death in three models with FGFR2c expression.

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Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer

[Cancer Letters] The authors conducted scRNA-seq for paired primary tumors and organoids from one cholangiocarcinoma and two pancreatic ductal adenocarcinoma patients.

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Proteome Signatures of Joint Toxicity to Arsenic (as) and Lead (Pb) in Human Brain Organoids with Optic Vesicles

[Environmental Research] Investigators utilized brain organoids with optic vesicles to systematically analyze the neurotoxicity of arsenic and lead.

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Pathological Deficit of Cystatin B Impairs Synaptic Plasticity in EPM1 Human Cerebral Organoids

[Molecular Neurobiology] Scientists investigated the involvement of cystatin B in synaptic plasticity, using synaptosomes from human cerebral organoids as well as from rodents’ brain.

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3D Hepatic Organoid Production from Human Pluripotent Stem Cells

[Differentiation] Researchers described the stepwise and fully 3D production of hepatic organoids from hPSCs. They optimized every differentiation step by screening for optimal concentrations and timing of differentiation signals in each differentiation step.

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Bioprinting Using Organ Building Blocks: Spheroids, Organoids, and Assembloids

[Tissue Engineering Part A] Investigators discuss the expanding range of organ building blocks (OBB), presents the rapidly evolving collection of bioprinting and bioassembly methods using these OBB, and outlines the advantages, challenges, and future perspectives of employing OBB in organ printing.

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Atorvastatin Calcium Alleviates UVB-Induced HaCat Cell Senescence and Skin Photoaging

[Scientific Reports] Through in vitro experiments with human immortalized keratinocytes (HaCat), researchers found that atorvastatin calcium could significantly reduce the ultraviolet radiation B-induced increased expression of age-related protein p16 and age-related gene p21, and also reduce the up-regulation of inflammatory factors such as IL-1 and IL-6.

Dysregulation in Keratinocytes Drives Systemic Lupus Erythematosus Onset

[Cellular & Molecular Immunology] Investigators found that the level of peroxisome proliferator-activated receptor gamma was substantially reduced in the skin lesions of patients, and replicating this reduction in mice led to rapid disease onset with multiple hallmarks of systemic lupus erythematosus.

USP19 Potentiates Autophagic Cell Death via Inhibiting mTOR Pathway through Deubiquitinating NEK9 in Pancreatic Cancer

[Cell Death & Differentiation] Scientists identified that ubiquitin-specific protease 19 (USP19) was downregulated in pancreatic tumor tissues and forced expression of USP19 diminished tumorigenicity of pancreatic cancer.

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