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[Proceedings of the National Academy of Sciences of the United States of America] Using a mouse that lacks a large intracellular region of β-dystroglycan (DG), researchers showed that the deletion of cytoplasmic β-DG leads to skeletal muscle pathology accompanied by postsynaptic disruption.

[Proceedings of the National Academy of Sciences of the United States of America] Using single-sarcomere imaging of skeletal muscle myofibrils under near-physiological conditions, investigators directly visualized myosin motors OFF-to-ON switch transitions within distinct regulatory zones of the filaments.

[Cell Death & Disease] Scientists reported upregulation of histone methyltransferase G9a in both aged human muscle and mouse muscle after injury. Deletion of G9a in either myeloid cells or myofibers accelerates muscle regeneration.

[Advanced Science] Through spatial proteomics of human colon and functional assays in primary human colonic smooth muscle cells, investigators identified Bridging Integrator 1 (BIN1) and Aldehyde Dehydrogenase 1B1 (ALDH1B1) as key regulators of intestinal motility.

[Skeletal Muscle] Scientists examine how enhancer-associated mechanisms enable muscle stem cells to interpret niche-derived signals, highlighting the roles of transcription factor networks, chromatin remodeling complexes, and enhancer-promoter interactions in coordinating gene expression.

[GEn1E Lifesciences, Inc. (Business Wire)] GEn1E Lifesciences, Inc. announced that the US FDA has granted both Orphan Drug Designation and Rare Pediatric Disease Designation to GEn-1123 for the treatment of Duchenne Muscular Dystrophy.