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Endometrial Cancer PDX-Derived Organoids (PDXOs) and PDXs with FGFR2c Isoform Expression Are Sensitive to FGFR Inhibition

[npj Precision Oncology] Researchers reported the establishment of 16 endometrial cancer (EC) PDXOs with or without FGFR2c expression. In vitro treatment of five EC PDXOs with BGJ398 showed significant cell death in three models with FGFR2c expression.

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Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer

[Cancer Letters] The authors conducted scRNA-seq for paired primary tumors and organoids from one cholangiocarcinoma and two pancreatic ductal adenocarcinoma patients.

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Proteome Signatures of Joint Toxicity to Arsenic (as) and Lead (Pb) in Human Brain Organoids with Optic Vesicles

[Environmental Research] Investigators utilized brain organoids with optic vesicles to systematically analyze the neurotoxicity of arsenic and lead.

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Pathological Deficit of Cystatin B Impairs Synaptic Plasticity in EPM1 Human Cerebral Organoids

[Molecular Neurobiology] Scientists investigated the involvement of cystatin B in synaptic plasticity, using synaptosomes from human cerebral organoids as well as from rodents’ brain.

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3D Hepatic Organoid Production from Human Pluripotent Stem Cells

[Differentiation] Researchers described the stepwise and fully 3D production of hepatic organoids from hPSCs. They optimized every differentiation step by screening for optimal concentrations and timing of differentiation signals in each differentiation step.

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Bioprinting Using Organ Building Blocks: Spheroids, Organoids, and Assembloids

[Tissue Engineering Part A] Investigators discuss the expanding range of organ building blocks (OBB), presents the rapidly evolving collection of bioprinting and bioassembly methods using these OBB, and outlines the advantages, challenges, and future perspectives of employing OBB in organ printing.

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LSD1 Drives Intestinal Epithelial Maturation and Controls Small Intestinal Immune Cell Composition Independent of Microbiota in a Murine Model

Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this developed state during adulthood. [Nature Communications] Full...

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.

From Stem Cells to Pancreatic β-Cells: Strategies, Applications, and Potential Treatments for Diabetes

[Molecular And Cellular Biochemistry] Scientists introduce the development of functional β-cells and their heterogeneity and then turn to highlight recent advances in the generation of β-cells from stem cells and their potential applications in disease modeling, drug discovery and clinical therapy.

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