[Cancer Discovery] Investigators discovered that breast cancer-derived lung metastases stimulate the proliferation of alveolar type II cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.
[NPJ Precision Oncology] Through integrative analysis of multimodal human data researchers demonstrated that the SP-D geneexpression is reduced to near absence in metastatic NSCLC tissue, linking its loss to metastatic progression.
[NPJ Precision Oncology] Scientists delineated the N1-Methyladenosine ( m1A) regulatory network in lung squamous cell carcinoma (LUSC). The dominant m1A writer of TRMT6 emerged as the most up-regulated regulator in LUSC through a comprehensive pan-cancer analysis.
[Scientific Reports] The authors investigated how miR-320a regulates RAD51 to affect the radiosensitivity of NSCLC. miR-320a expression in NSCLC tissues and cell lines was evaluated using The Cancer Genome Atlas data and qRT-PCR.
[Scientific Reports] Researchers investigated the molecular mechanism by which propofol enhances chemosensitivity in NSCLC. In vitro experiments were performed to evaluate the effects of propofol on NSCLC cell lines and to elucidate the underlying molecular mechanisms.
[Physiological Reviews] Scientists explore the current knowledge of healthy lung aging, discuss which pathomechanisms in chronic lung disease are characterized by senescence, and summarize current target therapeutics and their impact on lung disease.
[European Journal of Medical Research] Researchers investigated how monocarboxylate transporters (MCT) 1 inhibition modulates Treg metabolism and function, and the potential implications for tumor immunotherapy.
[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.
[FEBS Journal] Scientists conducted single-cell transcriptomic and immunophenotypic analyses of liver- and spleen-derived Tregs from neonatal and adult mice.