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[Cell Reports] Scientists identified pleiotrophin (Ptn) as a regulator of presynaptic development. Affinity purification-based proteomics shows that Ptn associates with heparan sulfate (HS)-modified neurexin1 in the brain through an HS-glycan-dependent mechanism.

[Communications Biology] The authors investigated whether daily light exposure promotes photoreceptor maturation by exposing retinal organoids to six hours of daily light starting from day 70 in vitro.

[Cancer Gene Therapy] Researchers investigated the use of stem cells from human exfoliated deciduous teeth (SHED) as a potential vehicle for oncolytic herpes simplex virus-1 therapy to enhance treatment efficacy.

[Trends in Pharmacological Sciences] The authors review emerging strategies to selectively target pathological tau, from gene silencing and immunotherapy to protein degradation and tau modification, for treating neurodegenerative diseases.

[Molecular Psychiatry] Scientists summarize current findings on GABA-mediated glial-neuronal crosstalk, with emphasis on its roles in CNS physiology and its multifaceted regulation in neurological and neuropsychiatric disorders.

[Experimental & Molecular Medicine] Investigators highlight how neural signals shape the tumor immune microenvironment, revealing neuroimmune pathways as potential targets to overcome immune evasion and enhance cancer immunotherapy.