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Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis

[Cancer Discovery] Investigators discovered that breast cancer-derived lung metastases stimulate the proliferation of alveolar type II cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.

Pulmonary Surfactant Protein D Reduces Lung Cancer Progression Associated with Decreased IL-4/STAT6 Signaling

[NPJ Precision Oncology] Through integrative analysis of multimodal human data researchers demonstrated that the SP-D geneexpression is reduced to near absence in metastatic NSCLC tissue, linking its loss to metastatic progression.

TRMT6-Directed m1a Modification Initiates Lung Squamous Cell Carcinoma via YTHDF3-Stabilized Cell Cycle Genes

[NPJ Precision Oncology] Scientists delineated the N1-Methyladenosine ( m1A) regulatory network in lung squamous cell carcinoma (LUSC). The dominant m1A writer of TRMT6 emerged as the most up-regulated regulator in LUSC through a comprehensive pan-cancer analysis.

miR-320a Enhances Radiosensitivity in Non-Small Cell Lung Cancer by Targeting RAD51 and Modulating Ferroptosis via GPX4

[Scientific Reports] The authors investigated how miR-320a regulates RAD51 to affect the radiosensitivity of NSCLC. miR-320a expression in NSCLC tissues and cell lines was evaluated using The Cancer Genome Atlas data and qRT-PCR.

Propofol Regulates METTL3-Mediated PARP-1 m6a Modification to Promote Parthanatos to Improve NSCLC Chemotherapy Resistance

[Scientific Reports] Researchers investigated the molecular mechanism by which propofol enhances chemosensitivity in NSCLC. In vitro experiments were performed to evaluate the effects of propofol on NSCLC cell lines and to elucidate the underlying molecular mechanisms.

Fueling the Fire: Metabolic Dysfunction and Senescence As Drivers of Lung Aging and Disease

[Physiological Reviews] Scientists explore the current knowledge of healthy lung aging, discuss which pathomechanisms in chronic lung disease are characterized by senescence, and summarize current target therapeutics and their impact on lung disease.

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MCT1 Inhibition Reprograms Treg Metabolism via ABC Transporters: Implications for Tumor Immunity and the Prognosis of Acute Myeloid Leukemia Patients

[European Journal of Medical Research] Researchers investigated how monocarboxylate transporters (MCT) 1 inhibition modulates Treg metabolism and function, and the potential implications for tumor immunotherapy.

Hyaluronic Acid-CD44 Signaling Defines Therapeutic Resistance and Immunosuppressive Microenvironment in Peritoneal Metastasis of Gastric Cancer

[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.

T-Bet Tissue-Resident Regulatory T Cells Are Enriched in the Neonatal Mouse Liver and Promoted by IL-27 and IFN-γ

[FEBS Journal] Scientists conducted single-cell transcriptomic and immunophenotypic analyses of liver- and spleen-derived Tregs from neonatal and adult mice.