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[Cell Stem Cell] The authors developed an iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”). Single-nucleus RNA sequencing of miBrains confirmed the presence of diverse cell populations and revealed transcriptional responses to α-synuclein pathology.

[Neuron] Scientists developed the fluorescent bifunctional reporter neuro-seeER, “see estrogen response”, that can be used to track changes in estrogen dynamics in vitro and in vivo, including longitudinally in behaving animals.

[Science Advances] Researchers showed that local synthesis of Regenerating Family Member 3α, REG3A, in injured nerves activates translation of axonal KH-type splicing regulatory factor, Khsrp, mRNA in regenerating axons to slow peripheral nervous system nerve regeneration.

[Genes & Diseases] The authors investigated the effects of CUDC-907 on glioblastoma using cellular, organoid, and animal models to assess its inhibitory potential and toxicity.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Investigators synthesize available literature on the role of the NGFR, particularly the p75 neurotrophin receptor, in glioblastoma progression.

[Yale School of Medicine] Yale School of Medicine received a grant of nearly $25 million from the Aligning Research to Impact Autism to map human brain development and investigate how and when autism diverges from typical development.