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[Diabetes] Scientists combined human islet single-cell transcriptomics with mouse pancreatic-cell profiling to show that pericytes, rather than endothelial cells, are the primary source of hepatocyte growth factor (HGF) in healthy islets.

[Journal of Materials Chemistry B] The authors reported the development of a sulfonium lipid nanoparticle system for pancreas-specific interleukin-10 mRNA delivery in acute pancreatitis.

[Cell Reports] Researchers uncovered serine protease inhibitor Kazal type 1 (SPINK1) as a putative determinant of PDAC progression with a previously unrecognized role in epigenomic regulation.

[Cell Reports] Scientists combined single-cell and spatial genomics with patient-derived organoids and tumor samples to show how increased high mobility group-box protein 2 (HMGB2) availability represents a transcriptional addiction that fuels cell-cycle progression and growth.

[Cancer Letters] Investigators explored the role of Pbrm1 in tumorigenesis and progression of PDAC by using genetically engineered mouse models.

[British Journal of Cancer] Researchers showed that dual-oxygen pancreatic cancer organoids better capture basal–classical tumor heterogeneity, with hypoxia preserving aggressive basal-like cell states found in patient tumors.