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[Cell Stem Cell] The authors demonstrated that chemical inhibition of zinc transportation boosts stem cell-derived islet organoids functional competence, offering a potential strategy to advance pre-adaptation to stress in regenerative medicine.

[Nature Communications] Researchers focused on neuronal activity in Rett syndrome patient-derived organoids, analyzing two types of MECP2 mutations—a missense mutation and a truncating mutation —using calcium imaging with three-photon microscopy.

[Cell Reports Medicine] Scientists established expandable, multi-lineage adult renal organoids directly from surgical specimens of autosomal-dominant polycystic kidney disease (ADPKD) patients and healthy donors, creating a three-dimensional high-content screening platform.

[Cell Death & Disease] Researchers developed a human induced pluripotent stem cell-derived retinal organoid model that recapitulates key aspects of age-related macular degeneration-associated photoreceptor degeneration.

[Communications Biology] Investigators developed a gravity-driven organoid perfusion platform facilitating scalable throughput and supporting drug sensitivity and toxicity assessment on organoids.

[Cell Stem Cell] With a primary emphasis on gastrointestinal malignancies, scientists outlined the capabilities and remaining limitations of organoid-based cancer models, including developmentally defined stem cell-derived systems that enable controlled early-stage modeling when premalignant material is scarce.