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Inner Ear Organoids: Recent Progress and Potential Applications
[Fundamental Research] To better understand the origin and application value of organoids, the authors reviewe the developmental history and advancement of inner ear organoid research.
Cancer Stem Cell News
Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells
[Biological Trace Element Research] The authors investigated the effects of boric acid on the expression of DNA double-strand break repair genes in breast CSCs, which has not been studied in the literature before.
Cancer Stem Cell News
Novel lncRNA Gm33149 Modulates Metastatic Heterogeneity in Melanoma by Regulating the miR-5623-3p/Wnt Axis via Exosomal Transfer
[Cancer Gene Therapy] Scientists investigated the role and mechanism of long non-coding RNAs in regulating the interaction between melanoma CSCs and non-CSCs during the metastatic colonization process.
Cancer Stem Cell News
SIRT6 Promotes Metastasis and Relapse in HER2-Positive Breast Cancer
[Scientific Reports] Scientists investigated the impact of SIRT6-overexpression in Delta16HER2 mice, which were a bona fide model of HER2-positive breast cancer.
Cancer Stem Cell News
Visualizing Cancer-Originating Acetate Uptake through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment
[Neuro-Oncology] Researchers explored acetate from glioblastoma cells, which triggered reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and MCT1 expression.
Cancer Stem Cell News
Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma
[Gastroenterology] demonstrated how lysyl oxidase (LOX), a known factor in collagen crosslinking, contributes to the development and progression of cholangiocarcinoma
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Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...
[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.
Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs
[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.
Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’
[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.
