[Scientific Reports] Researchers show that low KIF4A expression is associated with aggressive gastric cancer, poorer survival, and activation of epithelial–mesenchymal transition programs.
[Scientific Reports] Investigators evaluated the therapeutic potential of a commercially available probiotic formulation using a human gut-on-a-chip model that mimics the physiodynamic intestinal microenvironment.
[Cancer Letters] Scientists provide a comprehensive analysis of the evolving landscape of immunotherapies designed to target colorectal cancer stem-like cells.
[Signal Transduction and Targeted Therapy] Researchers applied 3D patient-derived, metastatic human mammary organoids to model apoptosis resistance, necroptosis, and inflammatory signaling using single-cell CITE-sequencing, time-lapse live cell brightfield, and immunofluorescent confocal microscopy.
[Cell Reports] Investigators presented an extensive catalog of mutational signatures induced by a panel of environmental carcinogens using human tissue-derived organoids coupled with high-fidelity duplex sequencing
[Journal of Translational Medicine] Scientists established a robust and clinically validated patient-derived organoid platform for hepatic malignancies that accurately predicts patient-specific drug responses.
[Nature Communications] Scientists investigated how Myosin Light Chain Phosphorylatable Fast (Mylpf) abundance impacts sarcomere growth. The two zebrafish Mylpf genes, mylpfa and mylpfb, are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb.
[Nature Biomedical Engineering] Researchers reported the systemic delivery of skeletal-muscle-targeted full-length DMD mRNA in a murine model of Duchenne muscular dystrophy (DMD) using allogenically engineered targeting extracellular vesicles.
[Cell Stem Cell] The authors created pleiotropic chimeric antigen receptor (CAR)-monocytes, revitalizing the injured heart via synergistic fibrosis clearance and myocardial reconstitution.