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[Diabetologia] The authors highlight recent discoveries in human pancreatic islet and β-cell biology, exploring how new models and technologies could advance strategies to restore insulin-producing cells in diabetes.

[FEBS Letters] Scientists take a β cell centric perspective to examine the evidence for autophagy/mitophagy across four clinically relevant diabetes categories and discuss the functional significance and complexity of these pathways in β cell failure.

[Erasca, Inc.] Erasca, Inc. announced that the US FDA has granted Fast Track Designation to ERAS-0015 for the treatment of patients with metastatic pancreatic adenocarcinoma.

[Nature Medicine] Scientists conducted the HEAL-CHF trial, in which patients with advanced heart failure with reduced ejection fraction were randomized to receive intramyocardial injections of allogeneic hiPSC-derived cardiomyocytes or were uninjected.

[ACS Nano] Researchers developed KINESIS (K⁺-Ion Nano-Electrode Selective Interface System), a potassium-selective nanoelectrode platform that enables label-free, single-cell monitoring of K⁺ dynamics in hiPSC-derived cardiomyocytes for cardiotoxicity testing and disease modeling.

[Cardiovascular Research] Investigators showed that Ffar4 protects cardiac muscle cells from ischemic injury by preserving mitochondrial function and cGMP signaling, helping prevent cardiac dysfunction after ischemia-reperfusion.