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Cancer Stem Cell News

RFX2 Promotes Tumor Cell Stemness through Epigenetic Regulation of PAF1 in Spinal Ependymoma

[Journal of Neuro-Oncology] The authors investigated the molecular mechanism that induce stem cell features in spinal ependymoma (SE). They found that RFX2 activates PAF1 transcription, which promoted tumor stemness of SE cells and led to the malignant progression of SE.

Cancer Stem Cell News

Biomarkers and Targeted Therapy for Cancer Stem Cells

[Trends In Pharmacological Sciences] Scientists provide an overview of the unique signaling and metabolic pathways of CSCs, summarize existing CSC biomarkers and CSC-targeted therapies, and discuss strategies to further differentiate CSCs from non-stem cancer cells.

Cancer Stem Cell News

BMP Signaling in Cancer Stemness and Differentiation

[Cell Regeneration] The authors provide a concise overview that highlights the diverse roles of the bone morphogenetic protein (BMP) signaling in various types of cancers.

Newsletters

Single-Organoid Analysis Reveals Clinically Relevant Treatment-Resistant and Invasive Subclones in Pancreatic Cancer

[NPJ Precision Oncology] Investigators comprehensively unraveled the intra-patient response heterogeneity and intrinsic aggressive nature of PDAC on bulk and single-organoid resolution.

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SMAD4 Endows TGF-β1-Induced Highly Invasive Tumor Cells with Ferroptosis Vulnerability in Pancreatic Cancer

[Acta Pharmacologica Sinica] The authors showed that SMAD4 status almost determined the orientation of transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition via the SMAD4-dependent canonical pathway in PDAC, which altered ferroptosis vulnerability.

Newsletters

BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1

[Advanced Science] Researchers highlighted the important roles of basic helix-loop-helix transcription factor 40 (BHLHE40)-mediated lipid peroxidation in inducing ferroptosis in pancreatic cancer (PCa) cells and provided a novel mechanism underlying sterol regulatory element-binding factor 1 (SREBF1) overexpression in PCa.

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Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...

[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.

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