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[Proceedings of the National Academy of Sciences of the United States of America] Using a clinically relevant closed-head weight-drop mouse model, scientists identified mtDNA-specific damage and increased expression of innate inflammatory markers in the cerebral cortex during the acute mild traumatic brain injury phase.

[Science Signaling] Researchers found that the neurotrophin brain-derived neurotrophic factor amplifies multiple neuron-intrinsic programs to foster axonal regeneration in human iPSC-derived lower motor neurons.

[Communications Biology] The authors introduced a higher-order model of the tripartite synapse, accounting for astrocyte-synapse-neuron interactions in short-term plasticity, such that astrocyte gliotransmission and pre-synaptic facilitation jointly modulate neurotransmitter release, generalizing earlier short-term plasticity models.

[Molecular Cancer Therapeutics] Scientists generated three distinct glioma stem cell lines from high-grade gliomas arising in mice with Nf1 and Trp53 mutations in cis and characterized the allografts resulting from one Nf1-glioma stem cell line by single cell and single nuclear RNA-seq.

[Molecular Cancer Therapeutics] Researchers generated three inducible CRISPR inhibition cell lines to deplete activated leukocyte cell adhesion molecule (ALCAM) and elucidate its role in neuroblastoma.

[Scientific Reports] To define the therapeutic relevance of PCSK9 inhibition in Alzheimer’s disease-like pathology, scientists examined SBC-115,076 in AlCl₃-challenged zebrafish larvae and mechanistically validated its effects using complementary endothelial–microglial in vitro models.