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[Microbiology Spectrum] Researchers identified a stably integrated and transcriptionally active anellovirus genome in anAML cell line, providing a unique model to study viral persistence in hematopoietic cells.

[Blood Advances] Scientists showed that CD55 protects hematopoietic stem and progenitor cells from complement-mediated damage in aplastic anemia, highlighting complement inhibition as a potential therapeutic strategy

[Nature Communications] Using murine models and human mixed lineage leukemia (MLL)-r leukemia cells, the authors showed that the FA pathway suppresses leukemogenesis by limiting error-prone non-homologous end joining-mediated genomic instability.

[Blood] By screening the nucleoporin (NUP) family, scientists identified NUP214 as a frequently overexpressed gene and a critical fitness determinant in leukemia stem cells (LSCs). NUP214 acts as a conserved driver of LSC survival by restricting heme catabolism, limiting Fe²⁺ accumulation, and suppressing lipid peroxidation.

[Leukemia] Researchers identified the RNA splicing factor PTBP1 as a key dependency in acute myeloid leukemia, sustaining leukemia by controlling the processing of essential oncogenic transcripts.

[Leukemia] Investigators mapped purinergic signaling at single-cell resolution in human cord blood stem and progenitor cells, revealing how ATP and adenosine pathways are organized across early blood cell development.