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Intestinal Cell News

OTUB2 Induces M2 Tumor-Associated Macrophage Polarization and Increases CD274 Expression in Gastric Cancer Cells to Aggravate the Progression of Gastric Cancer

[Cell Death & Disease] Stable OTUB2 overexpression and knockdown cells were cocultured with M0 macrophages to study tumor-associated macrophages polarization.

Intestinal Cell News

Emergence of Oncofetal Plasticity Is Ubiquitous in Early Colorectal Cancers

[Nature] Investigators showed that metastasis-associated oncofetal cell states already emerge at the earliest stages of colorectal cancer, concurrent with invasive front formation.

Intestinal Cell News

RNA‑Binding Proteins As Epithelial Transcriptome Orchestrators in Gastric Cancer: Immune‑Metabolic Crosstalk and Therapeutic Vulnerability (Review)

[International Journal of Molecular Medicine] Scientists highlight the gastric cancer‑specific mechanisms, controversial scientific issues and latest clinical translation progress of RNA‑binding proteins (RBPs) and propose personalized treatment strategies based on the molecular characteristics of RBPs.

Newsletters

Bottom-Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

[Advanced Materials] A bottom-up biomaterial-based platform was introduced to program cell state changes in pancreatic cancer organoids by tuning minimal adhesion cues within a synthetic matrix.

Newsletters

Pre-Adaptation of Stem Cell-Derived Islet Organoids to Hypoxia via Zinc Transportation Inhibition Drives Angiogenesis

[Cell Stem Cell] The authors demonstrated that chemical inhibition of zinc transportation boosts stem cell-derived islet organoids functional competence, offering a potential strategy to advance pre-adaptation to stress in regenerative medicine.

Newsletters

Early Differential Impact of MeCP2 Mutations on Functional Networks in Rett Syndrome Patient-Derived Human Cortical Organoids

[Nature Communications] Researchers focused on neuronal activity in Rett syndrome patient-derived organoids, analyzing two types of MECP2 mutations—a missense mutation and a truncating mutation —using calcium imaging with three-photon microscopy.

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Asahi Kasei Announces Initiation of Phase I Clinical Trial for Novel Peptide Candidate Targeting Autoimmune Diseases

[Asahi Kasei] Asahi Kasei announced the initiation of a Phase I clinical trial for AK1940, a novel peptide-based investigational compound developed to address significant unmet medical needs in patients with autoimmune diseases.

FDA Accepts Application for Genentech’s Gazyva for the Treatment of the Most Common Form of Lupus

[Genentech] Genentech announced that the US FDA has accepted the company’s supplemental Biologics License Application for Gazyva® for the treatment of systemic lupus erythematosus.

Low Dose IL-2 Therapy Restores Regulatory T Cells in Patients with Systemic Lupus Erythematosus in a Dose-Dependent Manner: A Phase IIb Trial

[Nature Communications] In this multicenter, double-blind, Phase IIb trial, 152 patients with active systemic lupus erythematosus were randomized to receive subcutaneous interleukin 2 or placebo every other day for 12 weeks, then weekly for another 12 weeks. Low-dose-IL2 drove the expansion of Tregs and altered Treg/effector T cell ratios.

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