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[Aging] Scientists discovered that miR-211-5p was a significantly downregulated miRNA in pancreatic cancer tissues compared to adjacent non-tumour tissues.

[Diabetes] Investigators developed a method for selective genetic targeting of human α cells and assessed RFX6-dependent α cell function.

[Nature Communications] The authors demonstrated a novel autocrine mechanism of β cell maintenance and function that was mediated by the peptide–amino acid transporter axis.

[New England Journal Of Medicine] In this Phase II, double-blind, randomized, placebo-controlled trial, scientists assigned patients with type 1 diabetes diagnosed during the previous 100 days to receive baricitinib or matched placebo orally for 48 weeks.

[Biochimica Et Biophysica Acta-Molecular Cell Research] The authors detail pancreatic expression of protein kinase D enzymes in normal individuals and pancreatitis and PDAC patients, as well as in mouse and rat animal models for these diseases.

[Molecular Therapy-Methods & Clinical Development] Investigators reported that plasmid encoding a trimeric spike protein with lipid nanoparticle delivery (pTS/LNP), similar to those in Moderna's COVID-19 vaccine, induced more effective humoral responses than naked pTS or pTS delivered via electroporation.