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MARCH2 Prevents Doxorubicin-Induced Cardiomyopathy by Stabilizing NR1H2 and Promoting Clearance of Apoptotic Cardiomyocytes

[Nature Communications] Scientists found that MARCH2 expression is significantly reduced in cardiac macrophages from doxorubicin-induced cardiomyopathy (DiCM) mice and human dilated cardiomyopathy patients.

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

[Advanced Healthcare Materials] The authors investigated the role of surface charge and synergistic mechano-electrical stimulation of piezoelectric poly(vinylidene fluoride) on the behaviour of H9c2 cardiac cells.

Arachidonate Lipoxygenase 5 Metabolism Axis Promoting Ferroptosis: A Potential Druggable Target for Doxorubicin-Induced Cardiomyopathy

[British Journal of Cancer] Researchers investigated the role of the ALOX5 metabolism axis in doxorubicin-induced cardiomyopathy and to elucidate its underlying mechanism using genetic and pharmacological approaches.

Dystrophins DP71 and DP427 Determine Cell Viability during Proliferation and Myofibre Differentiation

[Cell Death & Disease] Scientists investigated the roles of DP427 and DP71 during cell proliferation and fibre differentiation. They included paralogous utrophins in our analyses, particularly the UP395 isoform, owing to its presence in muscle and its partial ability to compensate for the lack of DP427.

TAK1 Is a Key Regulator of Oncogenic Signaling and Differentiation Blockade in Rhabdomyosarcoma

[Oncogene] Investigators showed that transforming growth factor β-activated kinase 1 (TAK1) expression and activity are markedly elevated in rhabdomyosarcoma cell lines and patient tumor specimens.

TGFβ1-Loaded Extracellular Matrix Hydrogels Promote Skeletal Muscle Stem Cell Regeneration via m6a-Mediated Integrin-ERK Signaling

[Journal of Translational Medicine] Researchers revealed a novel m6A-mediated pathway that integrates biochemical (TGFβ1) and mechanical signals to direct skeletal muscle stem cells fate

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Early Fibrotic Niches Establish Tumor-Permissive Microenvironments

[Nature] Using integrated single-cell, spatial, and functional analyses, scientists defined the earliest multicellular events that license this transition following oncogenic activation in the lung.

SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts

[Circulation] The functional role of SIRT5 in cardiac fibrosis was evaluated through cardiac fibroblast-specific knockout and overexpression of Sirt5 in mice.

VAP1 Promotes Cardiac Fibrosis by Enabling PDGFR Signaling in Myofibroblasts

[Experimental & Molecular Medicine] Researchers investigated the role and targetability of vascular adhesion protein 1 (VAP1) in cardiac fibrosis.