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ESC & iPSC News

A Scalable Embryonic Stem Cell-Based Platform for Efficient Generation of Mitochondrial DNA Mutant Mice

[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed a scalable embryonic stem cell–based platform for efficient production of mitochondrial DNA mutant mice.

ESC & iPSC News

EpCAM Supports Exit from Pluripotency of Embryonic Stem Cells via Eomes

[Cell Death & Disease] Researchers presented a role of epithelial cell adhesion molecule (EpCAM) in exit from pluripotency of murine ESCs to establish cardiomyocytes in embryoid bodies.

ESC & iPSC News

An Optimized Protocol for Efficient Derivation of Pancreatic Islets from Multiple Human Pluripotent Stem Cell Lines

[Stem Cell Reports] Investigators developed a robust protocol that generates functional stem cell-derived islets from all eight tested hPSC lines.

ESC & iPSC News

Generating Microglia-Integrated Cortical Organoids from Human Embryonic Stem Cells

[Stem Cell Reviews and Reports] Researchers presented a protocol for generating cortical organoids integrated with microglial progenitors derived from hESCs by differentiating hESCs into Yolk Sac Embryoid Bodies.

ESC & iPSC News

Human iPSC Cardiomyocyte Patch Transplantation Modifies Extracellular Matrix and Fibroblast Behavior after Myocardial Infarction

[iScience] The authors showed that transplantation of the hiPSC-derived cardiomyocyte patch onto the damaged heart after myocardial infarction increases the ratio of collagen type I against collagen type III to modulate alignment of the collagen fibers at the infarcted zone.

ESC & iPSC News

PICH Facilitates iPSC Reprogramming by Alleviating Genomic Instability Induced by DNA Replication Stress

[FEBS Journal] Scientists showed that Plk1-interacting checkpoint helicase (PICH) deficiency induces genomic instability and drastically reduces the efficiency of iPSC generation.

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CAR-Neutrophils Produced In Vivo to Treat Glioma

[Nature Biomedical Engineering] Scientists developed a neutrophil-specific modified RNA translation platform, termed NeuSMRT, that enables the expression of CARs in primary neutrophils. In a syngeneic glioma model, CAR-neutrophils produced in vivo significantly inhibited tumour growth and prolong survival.

CAR-X Cell Engineering

[Nature Reviews Bioengineering] The authors discuss different CAR-engineered immune cells for therapeutic applications by highlighting how unique immune attributes, along with cell-specific manufacturing strategies and CAR designs, address challenges faced by conventional CAR-T cell therapy.

Therapeutic Targeting of BCL-2 during CART Cell Production Augments Potency through Non-Apoptotic Adaptive Changes

[Signal Transduction and Targeted Therapy] Scientists revealed that venetoclax treatment during ex vivo expansion of CART cells, prepared from T cells from healthy donors or chemotherapeutically pretreated patients, potently augments antitumor efficacy in a BCL-2-dependent manner.

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