| Vol. 8.34 – 16 September, 2022 |
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| The authors demonstrated that transit-amplifying cells, marked by unconventional prefoldin RPB5 interactor, controlled R-spondin production to guide intestinal stem cell proliferation. [Journal of Experimental Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers revealed significant differences in coronin-like actin-binding protein 1C derived circRNA hsa_circ_0000437 between gastric cancer and para-cancer tissues. [Oncogene] |
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| Investigators screened several representative food-borne comparator engineered nanomaterials and reported that human colon cancer cells could insidiously exploit ZnO nanoparticle-induced adaptive response to acquire resistance against several chemotherapeutic drugs. [Nanoscale] |
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| Scientists identified a second adhesion complex localized at the proximal base region of microvilli. This complex contained the immunoglobulin superfamily member TMIGD1, which directly interacted with the microvillar scaffolding proteins EBP50 and E3KARP. [Science Signaling] |
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| CircRNA microarray and quantitative real time-polymerase chain reaction analyses were performed to investigate and verify the candidate dysregulated circRNA. [Cell Death & Disease] |
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| Functionally, circPGD promoted cell proliferation, migration, and suppressed apoptosis in vitro. Mechanistically, circPGD sponged miR-16-5p for relieving miR-16-5p suppression on the corresponding target ABL2 via the SMAD2/3 and YAP signaling pathways. [Cell Death Discovery] |
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| The authors provide evidence that the expression of cancer stem cell‑related genes and their potential regulatory miRNAs contribute to intra‑tumor heterogeneity in colorectal carcinoma, lymph node, and liver metastasis. [Oncology Reports] |
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| Scientists investigated the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer. [BMC Cancer] |
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| Since mTOR, Astrin, and hypoxia-inducible factors are involved in promoting the growth and survival of cancer cells, researchers investigated the possible interaction between them in cultured colon cancer cells. [Biochemistry and Biophysics Reports] |
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| The authors present an overview of the current understanding of the role of goblet cells and the mucus layer in maintaining intestinal health during steady-state and how alterations to these systems contribute to inflammatory and infectious disease. [Nature Reviews Gastroenterology & Hepatology] |
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| Investigators discuss the beneficial effects of metformin on IBD using the results of in vitro, in vivo, and clinical studies. [International Immunopharmacology] |
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| Agenus announced the initiation of a global Phase II program of botensilimab, an Fc-enhanced anti-CTLA-4 that activates innate and adaptive immune responses. [Agenus] |
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| February 19 – 22, 2023 Banff, Alberta, Canada |
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| Sunnybrook Research Institute – Toronto, Ontario, Canada |
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| Columbia University – New York, New York, United States |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| Technical University of Denmark – Lyngby, Denmark |
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| Beckman Research Institute of City of Hope – Duarte, California, United States |
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