|
|
Vol. 13.46 – 22 November, 2022
|
|
|
|
|
|
|
|
Using metabolomic profiling and functional interrogation of metabolic dependencies, scientists identified two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors.
[Nature Cancer]
|
|
|
|
|
|
PUBLICATIONSRanked by the impact factor of the journal
|
|
|
|
|
|
|
|
The effects of the small extracellular vesicles in vitro were analyzed on caerulein-simulated pancreatic acinar cells.
[Journal of Controlled Release]
|
|
|
|
|
|
Altered material properties of the INS-1 cells revealed the regulation of multiple glucose stimulation patterns. Rapidly responding to high glucose, INS-1 cells presented the unique meshing networks of elasticities.
[Biomaterials Advances]
|
|
|
|
|
|
Researchers found long-term intervention of glucagon, or glucagon intervention with the presence of palmitic acid, downregulated the β-cell specific markers, and inhibited insulin secretion in cultured β-cells.
[American Journal of Physiology-Endocrinology and Metabolism]
|
|
|
|
|
|
|
|
On target effects of WB436B were examined by microscale thermophoresis, surface plasmon resonance, in vitro kinase assay, RNA sequencing, and selective cell growth inhibition assessment.
[Clinical Cancer Research]
|
|
|
|
|
|
Genetic experiments demonstrated that NF1 ablation culminated in acinar-to-ductal metaplasia, an early step in PDAC, and NF1 haploinsufficiency resulted in a dramatic acceleration of KrasG12D-driven PDAC.
[Cell Reports]
|
|
|
|
|
|
A set of preclinical models was obtained by engrafting mouse PDAC-derived cells into syngeneic immune-competent mice, as well as by orthotopically transplanting patient-derived PDAC tumour into human immune-system-reconstituted mice.
[British Journal of Cancer]
|
|
|
|
|
|
The expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in pancreatic cancer tissues and may be a potential prognostic indicator.
[Experimental and Molecular Medicine]
|
|
|
|
|
|
Scientists focused on the function and molecular mechanism of a novel lncRNA linc-UROD in pancreatic cancer (PC), which was found to be upregulated in PC cells.
[Translational Oncology]
|
|
|
|
|
|
|
|
|
The authors introduce the transcriptional programs regulated by NRF2 as well as how NRF2 itself is regulated.
[Diabetes]
|
|
|
|
|
|
Investigators provide insight into the relationship between diabetes and pancreatic cancer and the methods that can be employed to diagnose this disease at an earlier stage successfully.
[Life Sciences]
|
|
|
|
|
|
|
|
Marker Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug (IND) application for MT-601, a multi-tumor-associated antigen-specific T cell product targeting six antigens, for the treatment of patients with locally advanced unresectable or metastatic pancreatic cancer.
[Marker Therapeutics, Inc.]
|
|
|
|
|
|
|
|
February 5 – 8, 2023
Keystone, Colorado, United States
|
|
|
|
|
|
|
|
|
|
|
STEMCELL Technologies, Inc. – Boston, Massachusetts, United States
|
|
|
|
|
|
|
Texas A&M University Health Science Center – Bryan, Texas, United States
|
|
|
|
|
|
|
King’s College London – London, England, United Kingdom
|
|
|
|
|
|
|
International Agency for Research on Cancer, WHO – Lyon, France
|
|
|
|
|
|
|
Max Delbrück Center for Molecular Medicine – Berlin, Germany
|
|
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News