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Vol. 14.10 – 14 March, 2023
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Investigators developed an experimental model that enforced the transition of PDAC cells toward a basal-like subtype.
[Gastroenterology]
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PUBLICATIONSRanked by the impact factor of the journal
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Researchers investigated whether methylation of histone H3 lysine 4, a marker of gene promoters with unresolved functional importance, was necessary for the maintenance of mature beta cell function.
[Diabetologia]
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The authors unraveled the molecular mode of action of ISL1 in controlling α cell fate and the formation of functional ß cells in the pancreas.
[Cell & Bioscience]
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To identify how loss of Chd4 impacts glucose homeostasis and gene expression programs in β-cells in vivo, researchers generated an inducible-β-cell-specific Chd4 knockout mouse model.
[Diabetes]
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Using a zebrafish nitroreductase-mediated β-cells ablation model, scientists uncovered that ghrelin-positive ɛ-cells in the pancreas acted as contributors to neogenic β-cells after extreme β-cell loss.
[Development]
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The authors reported that MafB deficiency impaired β cell clustering and islet formation, but also coincided with loss of neurotransmitter and axon guidance receptor gene expression.
[Development]
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Using an experimental pipeline enabling PDAC organoid isolation and collection based on invasive phenotype, scientists assessed the transcriptomic programs associated with invasion in their organoid model.
[Journal Of Clinical Investigation]
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In vivo, researchers found that inflammatory cancer-associated fibroblasts displayed a hypoxic gene expression and biochemical profile and were enriched in hypoxic regions of PDAC tumors.
[Cancer Research]
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Using a tissue microarray, scientists found that high stomatin-like protein 2 (STOML2) expression was correlated with higher survival of patients with pancreatic cancer.
[Cell Death & Disease]
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Investigators discovered that ubiquitin‑conjugating enzyme E2K (UBE2K) was expressed at high levels and indicated the poor prognosis of patients with PDAC.
[International Journal of Oncology]
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Scientists summarize the connection between the metabolic pathways and molecular mechanisms of iron metabolism and ferroptosis in type 2 diabetes mellitus.
[Cell Death & Disease]
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Iok In Christine Chio, PhD, and Oliver Clarke, PhD, both early-career investigators at Columbia University Vagelos College of Physicians and Surgeons, were awarded 2023 Hirschl Trust Research Awards by the Irma T. Hirschl Trust Research Scientist Program.
[Columbia University]
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PanCAN has received a transformational gift of $25 million that will accelerate the organization’s pioneering research initiatives to improve the detection and treatment of pancreatic cancer.
[AAPG Bulletin]
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April 24 – 25, 2023
Cambridge, Massachusetts, United States
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UCSF Diabetes Center – San Francisco, California, United States
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Medical College of Wisconsin – Milwaukee, Wisconsin, United States
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Moffitt Cancer Center – Tampa, Florida, United States
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Dana-Farber Cancer Institute – Boston, Massachusetts, United States
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University of Missouri – Columbia, Missouri, United States
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