Human Immunology News Volume 11.49 | Dec 12 2023

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    Noshin Noorjahan
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    2023-12-12 | HIN 11.49


    Human Immunology News by STEMCELL Technologies
    Vol. 11.49 – 12 December, 2023
    TOP STORY

    Dendritic Cell-Based In Situ Nanovaccine for Reprogramming Lipid Metabolism to Boost Tumor Immunotherapy

    Scientists engineered an in situ nanovaccine based on lipid metabolism-regulating and innate immune-stimulated nanoparticles.
    [ACS Nano]

    AbstractGraphical Abstract
    Explore how immune cell isolation can be made easy
    PUBLICATIONSRanked by the impact factor of the journal

    Innate TCRβ-Chain Engagement Drives Human T Cells toward Distinct Memory-Like Effector Phenotypes with Immunotherapeutic Potentials

    Researchers reported that nonclonotypic T cell receptor (TCR) engagement induced distinct phenotypes in TCRαβ+ cells.
    [Science Advances]

    Full Article

    Bifidobacterium infantis Associates with T Cell Immunity in Human Infants and Is Sufficient to Enhance Antigen-Specific T Cells in Mice

    Bacille Calmette-Guerin-specific immune responses were analyzed at seven weeks of age in infants who were HIV exposed but uninfected, and responses were categorized as high or low.
    [Science Advances]

    Full Article

    Cancer CD39 Drives Metabolic Adaption and Mal-Differentiation of CD4+ T Cells in Patients with Non-Small-Cell Lung Cancer

    Scientists demonstrated that human non-small-cell lung cancer cells, including tumor cell lines and primary tumor cells from clinical patients, efficiently drove the metabolic adaption of human CD4+ T cells, instructing differentiation of regulatory T cells while inhibiting effector T cells.
    [Cell Death & Disease]

    Full Article

    Decoding the Expression Pattern of MUC3A in Gastric Adenocarcinoma: Unveiling the Key to Successful Immunotherapy

    Immunohistochemistry was used to determine the percentage of MUC3A-positive tumor cells in primary and metastatic tumor sites of 190 gastric adenocarcinoma patients.
    [Expert Opinion on Therapeutic Targets]

    Abstract

    Interleukin 1β and Interleukin 6 Production in Human Immune Cells Is Stimulated by the Antibacterial Compound Triclosan

    Production of IL-1β and IL-6 was increased by exposure to one or more concentration of triclosan at each length of exposure- 10 minutes, 30 minutes, 6 hours, and 24 hours.
    [Archives Of Toxicology]

    Abstract

    T Proliferating Cells Derived Autophagy Signature Associated with Prognosis and Immunotherapy Resistance in a Pan-Cancer Analysis

    Investigators manually curated an autophagy gene set and defined a pan-cancer autophagy signature by comparing malignant tissues and normal tissues in The Cancer Genome Atlas cohort.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Siglec-15 on Macrophages Suppress the Immune Microenvironment in Patients with PD-L1 Negative Non-Metastasis Lung Adenocarcinoma

    Researchers collected samples of 135 non-small cell lung cancers and found that Siglec-15 and PD-L1 expression were independent in non-small cell lung cancer by multiple immunofluorescence staining.
    [Cancer Gene Therapy]

    Full Article

    Chemokine- and Chemokine Receptor-Based Signature Predicts Immunotherapy Response in Female Colorectal Adenocarcinoma Patients

    The authors explored the expression profiles of chemokines and chemokine receptors and constructed a chemokine- and chemokine receptor-based signature in female patients with advanced colorectal adenocarcinoma.
    [Scientific Reports]

    Full Article

    Immune Checkpoint Status and Exhaustion-Related Phenotypes of CD8+ T Cells from the Tumor-Draining Regional Lymph Nodes in Breast Cancer

    Multicolor immunophenotyping was used to determine the expression of PD-1, TIM-3, LAG3, CTLA-4, CCR7, CD45RO, CD127, CD25, CXCR5, and ICOS molecules on CD3+CD4−CD56−CD8+ cytotoxic T cells freshly obtained from the lymph nodes and the peripheral blood samples of the breast cancer patients.
    [Cancer Medicine]

    Full Article
    Learn how to keep your lab stockroom and cold reagents organized.
    REVIEWS

    Fcγ Receptors and Immunomodulatory Antibodies in Cancer

    Scientists review the impact of genetic variability of human FcγRs on the activity of therapeutic antibodies and how antibody engineering is being utilized to develop the next generation of cancer immunotherapies.
    [Nature Reviews Cancer]

    Full Article

    Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines

    Investigators discuss recent advancements in the design of neoantigen-based cancer vaccines emphasizing the identification, validation, formulation, and targeting of neoantigens while addressing the challenges posed by tumor heterogeneity.
    [Cancer Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Takeda and The New York Academy of Sciences Announce 2024 Innovators in Science Award Winners

    Takeda and The New York Academy of Sciences announced the winners of the 2024 Innovators in Science Award for their excellence in, and commitment to, innovative science that has significantly advanced the field of research in cancer immunology.
    [The New York Academy of Sciences]

    Press Release
    FEATURED EVENT

    The 52nd Annual Meeting of the Japanese Society for Immunology

    January 17 – 19, 2024
    Chiba, Japan

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Immunology

    University of Surrey – Surrey, England, United Kingdom

    PhD Positions – Tissue Regeneration and Cancer Immunotherapy

    Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany

    Postdoctoral Scientists – Regulatory Lymphocytes & Tissue Resident Cells Crosstalk

    Institut Necker Enfants Malades – Paris, France

    Postdoctoral Position – Inflammation/Regeneration

    Institut Pasteur – Paris, France

    Faculty Positions – Medicine

    Westlake University – Zhejiang, China

    > See All Jobs

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