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Vol. 13.01 – 21 January, 2025
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Researchers investigated how KRAS-mutated epithelial cells acquired the capacity to escape senescence or even immune clearance, thereby progressing to advanced pancreatic ductal adenocarcinoma.
[Molecular Cancer]
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PUBLICATIONSListed by the impact factor of the journal
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To analyze the immune response to O-phosphoseryl-tRNA:selenocysteine-tRNA synthase (SepSecS) in patients with autoimmune hepatitis at the clonal level, scientists combined sensitive high-throughput screening assays with the isolation of monoclonal antibodies and T cell clones.
[Journal of Clinical Investigation]
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In this first trial combining a poly(ADP-ribose) polymerase inhibitor with high-dose chemotherapy, olaparib/vorinostat/GemBuMel was safe and showed promising activity in refractory lymphomas, including post-CAR-T relapses.
[Clinical Cancer Research]
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The authors investigated the novel role of mitochondrial STAT3 (mitoSTAT3) in Th17 cells and fibroblast-like synoviocytes and analyzed the correlation of mitoSTAT3 with rheumatoid arthritis.
[Experimental & Molecular Medicine]
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EXCEL examined the feasibility of conducting a large-scale randomized controlled trial comparing the effects of a remotely monitored, home-based, exercise program with standard of care for individuals with systemic lupus erythematosus.
[Lupus Science & Medicine]
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Investigators employed single-cell multi-omics analysis to investigate the molecular biomarkers and prognostic factors linked to B cell subpopulations in human nasopharyngeal carcinoma while examining the underlying mechanisms.
[Journal of Cancer]
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Scientists developed a technique for inducing monocytes from hematopoietic stem and progenitor cells by using a serum-free medium supplemented with optimal concentrations of serum substitutes and cytokines.
[Stem Cells and Development]
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Researchers explored the association between the CD4/CD8 ratio and T lymphocyte activities in people living with HIV.
[BMC Infectious Diseases]
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Investigators evaluated the in vitro antitumor activity of the multi-kinase inhibitor linifanib, either alone or in combination with metronomic vinorelbine or etoposide, on cutaneous T cell lymphomas cells.
[Investigational New Drugs]
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Recent translational research has revealed key mechanisms of vitiligo, including cellular stress, innate immune activation, T cell-mediated elimination of melanocytes from the skin resulting in clinically apparent white spots, and stem cell regeneration that reverses established lesions.
[Journal of Clinical Investigation]
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Vera Therapeutics, Inc. announced an exclusive license agreement with Stanford University for a novel, next-generation fusion protein targeting BAFF and APRIL, known as VT-109, with wide therapeutic potential across the spectrum of B cell-mediated diseases.
[Vera Therapeutics, Inc.]
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February 20-22, 2025
Paris, France
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Karolinksa Institutet – Solna, Sweden
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Biogen – San Francisco, California, United States
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Technical University of Munich – Munich, Germany
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University of North Carolina Lineburger Cancer Center – Chapel Hill, North Carolina, United States
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Dana-Farber Cancer Institute – Boston, Massachusetts, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
