 | | Vol. 13.09 – 13 May, 2025 |
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| Investigators suggested that given both treatment-related harms and benefits, immune checkpoint inhibitor (ICI) + chemotherapy use in the first systemic anticancer treatment setting requires informed decision-making; the potential benefits of ICI + chemotherapy vs single ICI in high-risk subgroups is encouraging.
[JAMA Oncology] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Single-cell RNA sequencing of naive and draining lymph nodes (LNs) of heart-transplanted mice and human LNs revealed a specific subset of CXCL12hi fibroblastic reticular cells that expressed high levels of lymphotoxin-β receptor and are enriched in the expression of immunoregulatory genes.
[Journal of Clinical Investigation] |
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| Investigators delineated the surface phenotypes and cytokine profiles of the aberrant lymphocyte populations in patients with lymphocytic variant hypereosinophilic syndrome.
[Journal of Allergy and Clinical Immunology] |
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| Scientists investigated the anti-tumor efficacy and immunomodulatory activity of sitravatinib in hepatocellular carcinoma.
[Clinical Cancer Research] |
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| Researchers introduced 9MW3811, a monoclonal antibody designed to neutralize IL-11 effectively.
[NPJ Precision Oncology] |
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| Researchers examined the interplay between miRNA expression profiles, Epstein-Barr virus reactivation, and immune checkpoint pathways in the context of small intestine disease development in chronic lymphocytic leukemia.
[Scientific Reports] |
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| Scientists explored the role of PTTG1 in ovarian cancer via the cGMP-PKG signaling pathway, focusing on its effects on M2 macrophage polarization and EMT progression in epithelial ovarian cancer cells.
[Discover Oncology] |
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| Bioinformatics analysis was used to identify differentially expressed genes and tumor-infiltrating immune cells between bladder cancer tissues and adjacent normal tissues.
[Discover Oncology] |
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| The authors discuss the structural and biochemical features of T cell interfaces at the cell and tissue levels, outlining how these interfaces dictate T cell function and fate.
[Nature Reviews Bioengineering] |
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| Investigators discuss recent advancements in understanding the complex functions of suppressor of cytokine signaling (SOCS) proteins in various immune cells, as well as the effects of SOCS proteins in human health and diseases.
[Journal of Advanced Research] |
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| Investigators at the Icahn School of Medicine at Mount Sinai have been named semifinalists—and one of the Top 40 Milestone Award winners—in the prestigious XPRIZE Healthspan, a $101 million global competition dedicated to transforming how we age.
[Mount Sinai] |
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| June 17-21, 2025
Lugano, Switzerland |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Fondazione per l’Istituto oncologico di ricerca IOR – Bellinzona, Switzerland |
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| | Aarhus University – Aarhus, Denmark |
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| | University of Glasgow – Glasgow, Scotland |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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