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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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miR-324-5p Mitigates Experimental Acute Pancreatitis by Suppressing Rock2 Expression
An in vivo acute pancreatitis mouse model was induced by caerulein, and agomir miR-324-5p was administered to assess its therapeutic effect.
[Mammalian Genome]
Abstract
AMP Deaminase-2- and Adenosine Deaminase-Mediated Disposal of β-Cell Intracellular Adenosine Protects against Multiple Low-Dose Streptozotocin-Induced Type 1 Diabetes
Investigators evaluated the importance of AMPD2 and ADA, two adenosine disposal enzymes, for β-cell survival and the development of type 1 diabetes.
[Biomedicine & Pharmacotherapy]
Full...
Autologous Multiantigen-Targeted T Cell Therapy for Pancreatic Cancer: A Phase I/II Trial
[Nature Medicine] To address tumor heterogeneity and mitigate immune evasion, an ex vivo expanded, polyclonal, T helper 1 cell-polarized T cell product targeting five tumor-associated antigens—PRAME, SSX2, MAGEA4, Survivin and NY-ESO-1—was developed.
Development and Prospective Validation of a Cell-Free DNA-Based Model for the Early Detection of Pancreatic Cancer
[Cancer Discovery] Investigators presented the development and validation of a noninvasive circulating cell-free DNA–based model for early pancreatic cancer detection.
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-Cell Polarization
[Cancer Discovery] Scientists showed that aryl hydrocarbon receptor ligands found in cigarette smoke, like the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, promote pancreatic dysplasia and pancreatic adenocarcinoma progression in a mouse model of this disease.
Noninvasive Evaluation and Clinical Value Prediction of Tumor-Infiltrating Neutrophil-to-T-Cell Ratio in Pancreatic Ductal Adenocarcinoma
[NPJ Digital Medicine] Researchers used pancreatic ductal adenocarcinoma (PDAC) patients from TCGA, CPTAC, and multiple centers to investigate and validate the relationship between the prognosis and tumor-infiltrating neutrophil-to-T-cell ratio (NTR) in the tumor immune microenvironment, including the correlation of NTR with chemotherapy response in PDAC.
Antimetastatic Effects of MRTX1133 KRAS G12D Specific Inhibitor in a Liver Metastatic Model of Pancreatic Ductal Adenocarcinoma
[Scientific Reports] Investigators analyzed the effect of MRTX1133 treatment on local tumor growth and liver metastasis development.
miR-4787-3p and miR-581 As Predictive Biomarkers for Fibrosis and Prognosis in Pancreatic Cancer
[Discover Oncology] The authors investigated the prognostic and fibrotic relevance of miR-4787-3p and miR-581 in pancreatic cancer.
Pancreatic Cancer: Molecular Pathogenesis and Emerging Therapeutic Strategies
[Signal Transduction and Targeted Therapy] Scientists highlight the complex interplay between KRAS signaling, the transcriptional coactivator YES1-associated protein and Src family kinases in the pathogenesis of pancreatic ductal adenocarcinoma and drug sensitivity.
A2 Biotherapeutics Announces FDA Clearance of IND for A2B543 for Treatment of Adults with Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors that Express...
[A2 Biotherapeutics, Inc.] A2 Biotherapeutics, Inc. announced that the US FDA has cleared the Company’s Investigational New Drug application for A2B543 for the treatment of germline heterozygous HLA-A*02 adults with recurrent unresectable, locally advanced, or metastatic solid tumors.
Generation and Validation of an Aryl Hydrocarbon Receptor Knockout Human Embryonic Stem Cell Line
[Endocrinology] To characterize the aryl hydrocarbon receptor pathway in developing human β-cells, scientists differentiated hESCs into “islet-like” cell clusters in vitro and treated cells with vehicle or dioxin for 24-hours at key stages of differentiation.
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
[Advanced Science] Investigators established CD168 as a marker for proliferating islet cells, providing a tool to study β-cell proliferation and novel insights into islet cell proliferation and maturation mechanisms.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
