Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

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Circulating Extracellular Vesicle Long RNA Profiling Combined with Machine Learning Unveils Novel Diagnostic Signature and Molecular Features in Chronic Pancreatitis

April 20, 2026

[Gut] Researchers constructed a diagnostic model for chronic pancreatitis (CP) and depicted molecular landscape of CP based on extracellular vesicle long RNA.

The Membrane Protein Amuc_1098 from Akkermansia Muciniphila Alleviates Acute Pancreatitis via TLR2 Signaling and Glycerophospholipid Metabolism Remodeling

April 20, 2026

[Nature Communications] Scientists investigated the effect of Amuc_1098 on acute pancreatitis in mice induced by caerulein combined with lipopolysaccharide or L-arginine.

Extracellular Vesicles Derived from hADSCs Rescue Acute Pancreatitis by Carrying -STK3 to Regulate Treg Differentiation

April 20, 2026

[iScience] Investigators conducted a phosphoproteomics analysis to evaluate phosphorylation levels, and administered extracellular vesicles derived from human adipose mesenchymal stem cells in a mouse model of severe acute pancreatitis and assessed their impact on Treg differentiation.

TRIM29 Promotes Pancreatic Cancer MVI via IκBα K48-Ubiquitination and NF-κB Activation in CXCL5⁺ Epithelial Cells

April 20, 2026

[Molecular Cancer] The authors investigated the mechanisms underlying the interaction and influence between microvascular invasion, which contributes to metastasis and poor prognosis of PDAC, and the tumor microenvironment.

Oncolytic Adenovirus in Combination with PD-L1-Targeted Radioimmunotherapy Exerts Synergistic Antitumor Effect against Pancreatic Cancer

April 20, 2026

[Journal for Immunotherapy of Cancer] Researchers demonstrated that relaxin can enhance intratumoral accumulation of programmed death-ligand 1-targeted RIT (lutetium-177-labeled atezolizumab) in a multifaceted manner to elicit synergistic antitumor immune response against desmoplastic and poorly immunogenic pancreatic tumors.

A FoxM1/Smad4 Positive Feedback Loop Promotes Pancreatic Cancer Progression

April 20, 2026

[Cell Death & Disease] Scientists utilized molecular cytology techniques, animal models, and human pancreatic cancer tissues to investigate the role of FoxM1 in Smad4 stabilization and its regulation of TGF-β signaling.

Combining Ferroptosis Inducers with Gemcitabine to Enhance Treatment Efficacy in Pancreatic Cancer

April 20, 2026

[Cancer & Metabolism] Investigators suggested that SRRM1 may serve as a predictive biomarker for gemcitabine (GEM) response in pancreatic cancer. Targeting SRRM1 in conjunction with ferroptosis inducers could offer a promising strategy to overcome GEM resistance.

Integrated Transcriptomic and Functional Characterization of Claudin-1 Reveals Its Oncogenic and Immunomodulatory Roles in Pancreatic Ductal Adenocarcinoma

April 20, 2026

[Tissue Barriers] Researchers performed an integrative analysis of 177 RNA-Seq datasets from TCGA and GTEx to characterize Claudin family alterations in PDAC.

Emerging Roles of Non-Coding RNAs in the Tumor Microenvironment of Pancreatic Cancer: Focusing on Current Challenges and Future Directions

April 20, 2026

[Gene] The authors summarize current knowledge on the multifaceted roles of ncRNAs across major cellular compartments of the tumor microenvironment, highlight key barriers that limit their diagnostic and therapeutic potential, and discuss emerging strategies that may accelerate the development of ncRNA-guided precision medicine in PDAC.

BBOT Granted US FDA Fast Track Designation for BBO-11818 for the Treatment of Adult Patients with Advanced KRAS-Mutant Pancreatic Ductal Adenocarcinoma

April 20, 2026

[BridgeBio Oncology Therapeutics, Inc.] BridgeBio Oncology Therapeutics, Inc. announced that the US FDA has granted Fast Track designation to BBO-11818 for the treatment of adult patients with advanced KRAS-mutant pancreatic ductal adenocarcinoma.

Glycemia Shifts Pancreatic Islet Rhythmicity by Influencing Interactions between δ Cells and α Cells

April 6, 2026

[Cell Systems] Scientists reported that a transition from hyperglycemia to euglycemia drove a coordinated shift from slow to fast islet Ca²⁺ oscillations (HESF) in vivo. HESF was conserved in pancreatic tissue slices but not in dispersed single β cells in vitro, linking the transition to paracrine signaling.

Gut Virome and Metabolic Associations in Patients with Acute Pancreatitis

April 6, 2026

[mSystems] Researchers comprehensively profiled virome alterations in acute pancreatitis and evaluated their associations with disease severity, etiology, and clinical parameters.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.