Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Subscribe|Follow Us On

Curing the Brain: In Search for New Astrocyte-Specific Therapies

April 28, 2026

[Experimental & Molecular Medicine] Scientists focus on astroglia; they briefly introduce these cells from an evolutionary and functional perspective, they present the general pathophysiology of astroglia, and finally they discuss how to target astroglial cells in cognitive brain disorders.

Modeling Glioblastoma Relapse In Vitro: A Critical Journey from 2D Models to Organ-on-Chip Alternatives

April 28, 2026

[NPJ Precision Oncology] The authors explore the spectrum of in vitro models that have been established to study human GBM relapse, including 2D cultures, 3D spheroids/organoids, microfluidic, and organ-on-a-chip systems.

Oxidative Stress-Induced Astrocytic Collagen Biosynthesis Drives Glial Barrier Formation and Neuronal Death in Ischemic Stroke

April 28, 2026

[Cell Metabolism] Investigators demonstrated that oxidative stress turns on astrocytic type I collagen production via a redox-glycosylation coupling mechanism.

On-Demand GLUT3 Expression Augments CAR T Cell Metabolic Fitness and Antitumor Efficacy in Preclinical Models of Glioblastoma

April 28, 2026

[Science Translational Medicine] Scientists showed that the dysfunction of chimeric antigen receptor T (CAR T) cells in glioblastoma is attributed, at least, in part, to glucose deficiency in the tumor microenvironment driven by the substantial consumption of glucose by cancer cells.

Remodeling Synaptic Connections via Engineered Neuron-Astrocyte Interactions

April 28, 2026

[Nature Communications] Researchers introduced Synthetic Trogocytosis, a synthetic molecular approach that enables astrocyte-mediated reduction of synaptic connectivity within targeted neural circuits.

Single-Nucleus Brain Transcriptomics Reveals Microglia Dysfunction in Multiple System Atrophy

April 28, 2026

[Nature Communications] The authors showed significant compositional differences in astroglia and microglia subtypes, while oligodendroglia and neurons are comparable.

Ser423-Phosphorylated MECP2 (MECP2-pS423) Accumulates in Human Brain, Cerebrospinal Fluid, and Serum in Sporadic Alzheimer’s Disease

April 28, 2026

[Acta Neuropathologica] Scientists developed an methyl-CpG-binding protein 2 (MECP2)-pS423-specific antibody, and a quantitative selective reaction monitoring assay based on LC–MS/MS analysis, and they used immunohistochemistry and proteomics to study MECP2-pS423.

Loss of Schizophrenia Risk Gene XPO7 Disrupts Neuronal Excitability and Network Regularity via Altered Na+ Channel Dynamics in Human Neurons

April 28, 2026

[Molecular Psychiatry] Researchers investigated the functional consequences of XPO7 loss of function in hiPSC-derived neurons, focusing on its role as a schizophrenia risk gene identified through recent large-scale exome sequencing analyses.

FABP7 Controls Radial Glial Scaffold Stability during Human Cortical Development

April 28, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Using human fetal brain slices, embryonic mouse model, cerebral organoids, and assembloids, investigators demonstrated that FABP7 is essential for maintaining radial glial scaffold architecture and coordinating neuronal positioning.

The DNA Demethylase TET1 Is a Pivotal Regulator of the miR-124/ISX9-Instructed Conversion of Astrocytes to Induced Neurons

April 28, 2026

[Molecular Neurobiology] The authors sought to identify the transcriptional regulators enacted by miR-124 and ISX9 to instruct the neurogenic conversion of astrocytes, aiming to reveal novel core neurogenic factors with instrumental role in the reprogramming process.

$13 Million CIRM Award to Fund Research on the Role of RNA Pollution in Neurodegenerative Diseases

April 28, 2026

[UC San Diego] Researchers at University of California San Diego School of Medicine, the Salk Institute and Sanford Burnham Prebys have received a four-year, $13 million award from the California Institute for Regenerative Medicine (CIRM) to investigate how to reverse age-related neurodegeneration by eliminating what the researchers call "RNA pollution" in aging neurons.

Last Patient Has Completed AlzeCure’s Phase Ib Clinical Study with NeuroRestore ACD856

April 20, 2026

[AlzeCure Pharma AB] AlzeCure Pharma AB announced that the last patient’s last visit has now occurred in the ongoing Phase Ib clinical trial of ACD856, the lead drug candidate within the NeuroRestore platform, which is being developed for Alzheimer’s disease and other indications.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.