Ser423-Phosphorylated MECP2 (MECP2-pS423) Accumulates in Human Brain, Cerebrospinal Fluid, and Serum in Sporadic Alzheimer’s Disease

Scientists developed an methyl-CpG-binding protein 2 (MECP2)-pS423-specific antibody, and a quantitative selective reaction monitoring assay based on LC–MS/MS analysis, and they used immunohistochemistry and proteomics to study MECP2-pS423.