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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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PGK1 Drives Cardiac Hypertrophy by Regulating the Vimentin/PI3K/Akt Pathway
[Circulation Research] Researchers highlighted a critical role for PGK1 (phosphoglycerate kinase 1) in myocardial hypertrophy, with downstream activation of the vimentin/PI3K/Akt/ferroptosis pathway.
Cardiomyocyte-Derived GPX4 Stabilizes BNIP3 to Facilitate Mitophagy and Mitigate Myocardial Ischemia/Reperfusion Injury
[Nature Communications] Scientists defined the role of the GPX4/BNIP3/USP20 complex in myocardial ischemia/reperfusion injury and uncovered a mechanism linking GPX4 to ferroptosis-related mitochondrial damage.
Mitochondrial Remodeling in Skeletal Muscle Underlies Exercise-Induced Reversal of Age-Associated Functional Decline in Mice and Humans
[Proceedings of the National Academy of Sciences of the United States of America] Investigators reported that exercise-induced improvements in functional capacity, including reduced frailty in old mice, are dependent on mitochondrial adaptations in skeletal muscle at structural, enzymatic, and functional levels.
Hypothyroidism Impairs Skeletal Muscle Regeneration after Injury by Altering Myogenic and Nonmyogenic Pathways
[JCI Insight] The authors used scRNA-seq and the fluorescent ubiquitination-based cell cycle indicator reporter mouse model to examine how hypothyroidism impacts repair processes after cardiotoxin-induced injury in mice.
CALHM5 Deficiency Alleviates Aortic Aneurysm by Regulating Smooth Muscle Calcium Homeostasis
[Proceedings of the National Academy of Sciences of the United States of America] Scientists characterized calcium homeostasis modulators 5 (CALHM5) as a plasma membrane ion channel abundant in smooth muscle cells of both humans and mice, playing a pivotal role in regulating calcium homeostasis.
Edelfosine Induces Cell Cycle Arrest and Apoptosis in Vascular Smooth Muscle Cells to Suppress Neointimal Hyperplasia
[Scientific Reports] Researchers tested whether edelfosine limits pathological vascular smooth muscle cell growth and neointimal lesion formation by enforcing cell-cycle arrest and apoptosis.
The Nonexcitable Smooth Muscle: Remodeling the Smooth Muscle Ion Transport Toolkit in Disease
[Physiological Reviews] Investigators build and refine a cohesive model whereby synthetic myocytes adopt a phenotype resembling non-excitable cells.
Transcriptomic Advances in Studies of Muscle Stem Cell Aging: From Bulk to Single-Cell and Beyond
[Cell Research] Scientists trace the evolution of transcriptomic technologies through the lens of muscle stem cells (MuSCs) aging and highlight how increasing resolution has reframed core models of MuSC decline and plasticity.
Affinia Therapeutics Receives Approval from Health Canada to Initiate the UPBEAT© Trial, a Phase I/II Clinical Trial to Investigate AFTX-201 as a Treatment for...
[Affinia Therapeutics] Affinia Therapeutics announced the approval of its clinical trial application by Health Canada for AFTX-201, a potential best-in-class investigational genetic medicine for the treatment of BAG3-associated DCM.
Precision BioSciences Receives FDA Fast Track Designation for PBGENE-DMD and Announces Duchenne Muscular Dystrophy Investor Event
[Precision BioSciences, Inc. (Business Wire)] Precision BioSciences, Inc., announced that the US FDA has granted Fast Track designation to PBGENE-DMD for the treatment of Duchenne muscular dystrophy (DMD)
YAP Induces a Prorenewal Metabolic State in Cardiomyocytes
[Circulation] Researchers investigated the role of YAP in mediating metabolic remodeling to overcome the cardiomyocyte proliferation barrier and enable cardiac regenerative repair after heart injury.
Restoration of RBM22 Overcomes the Transcriptional and Epigenetic Barriers of Cardiomyocyte Proliferation for Heart Regeneration
[Nature Communications] Scientists identified RNA-binding motif 22 (RBM22) as a pivotal regulator of cardiomyocyte proliferation. Cardiomyocyte-specific deletion of Rbm22 impaired neonatal heart regeneration and exacerbated post-infarction ventricular remodeling in adult mice.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
