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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
MEDIPOST Inc. Announces $140 Million in Funding to Accelerate Late-Stage Clinical Development
MEDIPOST, Inc. announced that its parent company, MEDIPOST Co., Ltd., has closed on $140 million in funding. The investment will accelerate the company’s Phase...
Cell Surface Engineering with a Pseudofibrotic ECM Reprograms the Antifibrotic Activity of Mesenchymal Stromal Cells
[Science Advances] Investigators presented a cell surface engineering strategy that reprograms the antifibrotic function of MSCs by constructing a pseudofibrotic extracellular matrix on their surface.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression
[Cancer Research] Scientists investigated the contribution of WT1+ mesenchymal cells to cancer-associated fibroblast populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer.
Effects of Local Anesthetics on Yield and Differentiation of Synovial Mesenchymal Stem Cells
[Scientific Reports] Scientists investigated whether clinically relevant concentrations of lidocaine and ropivacaine affect synovial MSC proliferation and differentiation.
Physical Differentiation of Adipose-Derived Mesenchymal Stem Cells Into Pancreatic Beta-Like Cells Using Cell-Imprinting and Evaluation of Insulin Production
[Adipocyte] Researchers physically induced the differentiation of rat adipose-derived mesenchymal stem cells into β-like cells using the cell-imprinting technique.
Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis
[Tissue Engineering and Regenerative Medicine] Umbilical cord mesenchymal stem cells were used to treat cirrhosis, ranging from end-stage to early stages, in methionine-deficient rats by modulating the Wnt pathway.
Exosomal Mir-451a Derived from Bone Marrow Mesenchymal Stem Cells Inhibits Macrophage M1 Polarization through the MIF/CD74 Signaling Pathway to Alleviate Acute Lung Injury
[Immunological Investigations] Researchers investigated the role of bone marrow MSC-Exos in acute lung injury through the regulation of macrophage polarization.
Therapeutic Efficacy of Mesenchymal Stem Cells (MSCs) on Alzheimer’S Disease: Review of Clinical Results
[Tissue Engineering and Regenerative Medicine] Investigators evaluate the therapeutic effects of MSCs on Alzheimer's disease patients through a review of clinical trial literature.
Mesenchymal Stromal Cells Counteract with Age-Related Immune Decline and Enhance Vaccine Efficacy by Modulating Endogenous Splenic Marginal Reticular Cells in Elderly Models
[Cellular & Molecular Immunology] Scientists discovered that the infusion of MSCs restored defects in the splenic stromal cell network and lymphocyte architecture in aged mice while also increasing specific antibody levels following vaccine immunization.
DMOG Enhances hUC-MSCs Paracrine Activity to Promote Endometrial Epithelial Cells Reconstitution via VSELs Formation in Ovariectomized Mice
[Stem Cell Reviews and Reports] Scientists explore whether dimethyloxalylglycine (DMOG)-pretreated human umbilical cord MSCs could repair estrogen deficiency-induced uterine atrophy.
Harnessing MSCs Plasticity: Mechanisms and Determinants of Bidirectional Immune Regulation in Stem-Cell-Based Immunotherapy
[Stem Cell Research & Therapy] The authors explore the potential factors influencing MSCs’ bidirectional immune regulation, then discuss the mechanisms underlying the immunosupportive and immunosuppressive effects of MSCs.
Cell Therapy in Sarcoma: Current Landscape and Future Directions
[Journal for Immunotherapy of Cancer] Scientists provide the current landscape and growing potential of cell therapies in sarcomas, including TCR-T, chimeric antigen receptor-T cells, tumor-infiltrating lymphocytes, natural killer cells, and mesenchymal stromal cells.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
