Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Caspase 5c Amplifies Wnt via APC Cleavage to Promote Intestinal Homeostasis

April 30, 2026

[Nature] Scientists showed that caspase 5 (CASP5) is restricted to the human intestinal epithelium and manifests as three isoforms—CASP5A, CASP5B and CASP5C—among which CASP5C uniquely promotes Wnt signalling, which is essential for epithelial development and regeneration

TGM2-Mediated Serotonylation of GPX4 Confers Ferroptosis Resistance to Promote Gastric Tumorigenesis

April 30, 2026

[Cell Discovery] Using untargeted plasma metabolomics, researchers revealed that the level of serotonin (5-HT) is significantly elevated in gastric cancer (GC) patients. Functionally, 5-HT treatment dramatically promoted GC cell proliferation and tumor growth in a dose-dependent manner.

NOD2 Drives Regenerative Fetal-Like Reprogramming in the Intestinal Epithelium

April 30, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Using irradiation injury as a model for small intestinal epithelium injury and repair, scientists found that the intestinal microbiota accelerated epithelial restitution by amplifying a repair-associated inflammatory response that promoted the emergence of fetal-like intestinal epithelial cells, marked by Ly6a and Clu.

RUNX2 Drives Adenoma-to-Carcinoma Transition in Colon Cancer

April 30, 2026

[Cell Death & Disease] Single-cell RNA sequencing revealed that CD8⁺ exhausted T cells were significantly enriched in adenoma and carcinoma tissues compared to adjacent normal tissues.

METTL3-Mediated m6a Modification of lncRNA MALAT1 Promotes Colorectal Cancer Progression by Activating the NF-κB Signaling Pathway

April 30, 2026

[Journal of Translational Medicine] Investigators elucidated the METTL3-N6-methyladenosine (m⁶A)-MALAT1-NF-κB regulatory axis in colorectal cancer, advancing the understanding of epigenetic mechanisms in cancer progression.

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2-P53 Pathway and M2 Macrophage Polarization

April 30, 2026

[Cancer Science] Researchers found that solute carrier family 1 member 3 (SLC1A3) is significantly overexpressed in colorectal cancer tissues compared to adjacent normal tissues, and elevated SLC1A3 expression is associated with poor prognosis.

SAC Regulates Glutathione Metabolism via the Keap1/Nrf2/GPX4 Signaling Pathway to Inhibit Ferroptosis and Alleviate Ulcerative Colitis

April 30, 2026

[Scientific Reports] Scientists investigated the molecular mechanism by which sulfurized garlic (SAC) inhibits ferroptosis through targeting Keap1/Nrf2/GPX4 signaling pathway, thereby restoring intestinal epithelial cell barrier function and alleviating ulcerative colitis.

The Role of Alternative Splicing in Gastric Cancer

April 30, 2026

[Biology Direct] The authors summarize the current knowledge of alternative splicing (AS) in gastric cancer (GC). Accumulating evidence shows that aberrant AS contributes to the oncogenesis, progression, invasion, metastasis, and drug resistance of GC.

The AGA Research Foundation Awards $2.9 Million in Digestive Health Research Funding

April 30, 2026

[American Gastroenterological Association] The American Gastroenterological Association (AGA) announced the selection of 84 recipients to receive $2.9 million in research funding through the annual AGA Research Foundation Awards Program.

Sabotaging Cancer Could Open Doors to New Treatments

April 17, 2026

[The University of Edinburgh] Researchers at the University of Edinburgh’s Institute of Genetics and Cancer are launching a £1.5 million Cancer Research UK-funded study to find a way to ‘trick’ bowel cancer cells.

CGF Induces ROS-Mediated Metabolic Reprogramming and Mitochondrial Dysfunction to Suppress Colorectal Cancer Progression

April 17, 2026

[iScience] Using colorectal cancer cell lines, organoids, and xenograft models, investigators showed that Cya-Gly-Fer (CGF) significantly inhibits tumor growth and metastasis.

Bacterial Protein-Oleate Complexes Induce Ferroptosis-Like Cell Death in Colorectal Cancer Cells by Disrupting Cell Membranes and Inhibiting the β-Catenin-GPX4 Axis

April 17, 2026

[Cell Death Discovery] Investigators demonstrated that α-helical proteins of bacterial origin can form tumoricidal complexes with sodium oleate.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.